Search Results - "Balazs, Alejandro B"

Delivering genes across the blood-brain barrier: LY6A, a novel cellular receptor for AAV-PHP.B capsids by Huang, Qin, Chan, Ken Y, Tobey, Isabelle G, Chan, Yujia Alina, Poterba, Tim, Boutros, Christine L, Balazs, Alejandro B, Daneman, Richard, Bloom, Jonathan M, Seed, Cotton, Deverman, Benjamin E

“…The engineered AAV-PHP.B family of adeno-associated virus efficiently delivers genes throughout the mouse central nervous system. To guide their application…”
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mRNA-based COVID-19 vaccine boosters induce neutralizing immunity against SARS-CoV-2 Omicron variant by Garcia-Beltran, Wilfredo F., St. Denis, Kerri J., Hoelzemer, Angelique, Lam, Evan C., Nitido, Adam D., Sheehan, Maegan L., Berrios, Cristhian, Ofoman, Onosereme, Chang, Christina C., Hauser, Blake M., Feldman, Jared, Roederer, Alex L., Gregory, David J., Poznansky, Mark C., Schmidt, Aaron G., Iafrate, A. John, Naranbhai, Vivek, Balazs, Alejandro B.

“…Recent surveillance has revealed the emergence of the SARS-CoV-2 Omicron variant (BA.1/B.1.1.529) harboring up to 36 mutations in spike protein, the target of…”
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Antibody-based protection against HIV infection by vectored immunoprophylaxis by Balazs, Alejandro B., Chen, Joyce, Hong, Christin M., Rao, Dinesh S., Yang, Lili, Baltimore, David

“…A single injection of a viral vector that encodes antibodies able to neutralize most HIV strains protects humanized mice from HIV infection. Anti-HIV…”
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Cell-to-cell spread of HIV permits ongoing replication despite antiretroviral therapy by Sigal, Alex, Kim, Jocelyn T., Balazs, Alejandro B., Dekel, Erez, Mayo, Avi, Milo, Ron, Baltimore, David

“…HIV persists through continued transmission Antiretroviral therapy suppresses, but does not eradicate, HIV infection. Low-level viraemia continues for life…”
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Protocol and Reagents for Pseudotyping Lentiviral Particles with SARS-CoV-2 Spike Protein for Neutralization Assays by Crawford, Katharine H D, Eguia, Rachel, Dingens, Adam S, Loes, Andrea N, Malone, Keara D, Wolf, Caitlin R, Chu, Helen Y, Tortorici, M Alejandra, Veesler, David, Murphy, Michael, Pettie, Deleah, King, Neil P, Balazs, Alejandro B, Bloom, Jesse D

“…SARS-CoV-2 enters cells using its Spike protein, which is also the main target of neutralizing antibodies. Therefore, assays to measure how antibodies and sera…”
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Adeno-associated virus gene delivery of broadly neutralizing antibodies as prevention and therapy against HIV-1 by Lin, Allen, Balazs, Alejandro B

“…Vectored gene delivery of HIV-1 broadly neutralizing antibodies (bNAbs) using recombinant adeno-associated virus (rAAV) is a promising alternative to…”
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Vectored immunoprophylaxis protects humanized mice from mucosal HIV transmission by Balazs, Alejandro B, Ouyang, Yong, Hong, Christin M, Chen, Joyce, Nguyen, Steven M, Rao, Dinesh S, An, Dong Sung, Baltimore, David

“…Delivery of HIV-specific neutralizing antibodies by adeno-associated virus vectors—termed vectored immunoprophylaxis (VIP)—has been shown to protect mice or…”
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Reduced BNT162b2 Messenger RNA Vaccine Response in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)–Naive Nursing Home Residents by Canaday, David H, Carias, Lenore, Oyebanji, Oladayo A, Keresztesy, Debbie, Wilk, Dennis, Payne, Michael, Aung, Htin, St. Denis, Kerri, Lam, Evan C, Rowley, Christopher F, Berry, Sarah D, Cameron, Cheryl M, Cameron, Mark J, Wilson, Brigid, Balazs, Alejandro B, Gravenstein, Stefan, King, Christopher L

“…Abstract After BNT162b2 messenger RNA vaccination, antibody levels to spike, receptor-binding domain, and virus neutralization were examined in 149 nursing…”
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Broad protection against influenza infection by vectored immunoprophylaxis in mice by Balazs, Alejandro B, Bloom, Jesse D, Hong, Christin M, Rao, Dinesh S, Baltimore, David

“…Gene therapy encoding a single influenza broadly neutralizing antibody durably protects even immunocompromised mice from illness caused by diverse influenza…”
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Maternal immune response and placental antibody transfer after COVID-19 vaccination across trimester and platforms by Atyeo, Caroline G., Shook, Lydia L., Brigida, Sara, De Guzman, Rose M., Demidkin, Stepan, Muir, Cordelia, Akinwunmi, Babatunde, Baez, Arantxa Medina, Sheehan, Maegan L., McSweeney, Erin, Burns, Madeleine D., Nayak, Ruhi, Kumar, Maya K., Patel, Chinmay D., Fialkowski, Allison, Cvrk, Dana, Goldfarb, Ilona T., Yonker, Lael M., Fasano, Alessio, Balazs, Alejandro B., Elovitz, Michal A., Gray, Kathryn J., Alter, Galit, Edlow, Andrea G.

“…The availability of three COVID-19 vaccines in the United States provides an unprecedented opportunity to examine how vaccine platforms and timing of…”
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MicroRNAs enriched in hematopoietic stem cells differentially regulate long-term hematopoietic output by O'Connell, Ryan M., Chaudhuri, Aadel A., Rao, Dinesh S., Gibson, William S. J., Balazs, Alejandro B., Baltimore, David

“…The production of blood cells depends on a rare hematopoietic stem-cell (HSC) population, but the molecular mechanisms underlying HSC biology remain…”
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Broadly neutralizing antibodies abrogate established hepatitis C virus infection by de Jong, Ype P, Dorner, Marcus, Mommersteeg, Michiel C, Xiao, Jing W, Balazs, Alejandro B, Robbins, Justin B, Winer, Benjamin Y, Gerges, Sherif, Vega, Kevin, Labitt, Rachael N, Donovan, Bridget M, Giang, Erick, Krishnan, Anuradha, Chiriboga, Luis, Charlton, Michael R, Burton, Dennis R, Baltimore, David, Law, Mansun, Rice, Charles M, Ploss, Alexander

“…In most exposed individuals, hepatitis C virus (HCV) establishes a chronic infection; this long-term infection in turn contributes to the development of liver…”
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Vectored antibody gene delivery protects against Plasmodium falciparum sporozoite challenge in mice by Deal, Cailin, Balazs, Alejandro B., Espinosa, Diego A., Zavala, Fidel, Baltimore, David, Ketner, Gary

“…Malaria caused by Plasmodium falciparum kills nearly one million children each year and imposes crippling economic burdens on families and nations worldwide…”
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Enhancing antibody responses by multivalent antigen display on thymus-independent DNA origami scaffolds by Wamhoff, Eike-Christian, Ronsard, Larance, Feldman, Jared, Knappe, Grant A., Hauser, Blake M., Romanov, Anna, Case, James Brett, Sanapala, Shilpa, Lam, Evan C., Denis, Kerri J. St, Boucau, Julie, Barczak, Amy K., Balazs, Alejandro B., Diamond, Michael S., Schmidt, Aaron G., Lingwood, Daniel, Bathe, Mark

“…Protein-based virus-like particles (P-VLPs) are commonly used to spatially organize antigens and enhance humoral immunity through multivalent antigen display…”
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Broadly Neutralizing Human Immunodeficiency Virus Type 1 Antibody Gene Transfer Protects Nonhuman Primates from Mucosal Simian-Human Immunodeficiency Virus Infection by Saunders, Kevin O, Wang, Lingshu, Joyce, M Gordon, Yang, Zhi-Yong, Balazs, Alejandro B, Cheng, Cheng, Ko, Sung-Youl, Kong, Wing-Pui, Rudicell, Rebecca S, Georgiev, Ivelin S, Duan, Lijie, Foulds, Kathryn E, Donaldson, Mitzi, Xu, Ling, Schmidt, Stephen D, Todd, John-Paul, Baltimore, David, Roederer, Mario, Haase, Ashley T, Kwong, Peter D, Rao, Srinivas S, Mascola, John R, Nabel, Gary J

“…Broadly neutralizing antibodies (bnAbs) can prevent lentiviral infection in nonhuman primates and may slow the spread of human immunodeficiency virus type 1…”
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Vectored delivery of anti-SIV envelope targeting mAb via AAV8 protects rhesus macaques from repeated limiting dose intrarectal swarm SIVsmE660 challenge by Welles, Hugh C, Jennewein, Madeleine F, Mason, Rosemarie D, Narpala, Sandeep, Wang, Lingshu, Cheng, Cheng, Zhang, Yi, Todd, John-Paul, Lifson, Jeffrey D, Balazs, Alejandro B, Alter, Galit, McDermott, Adrian B, Mascola, John R, Roederer, Mario

“…Gene based delivery of immunoglobulins promises to safely and durably provide protective immunity to individuals at risk of acquiring infectious diseases such…”
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Neutralization and binding antibody response to second bivalent COVID‐19 vaccination in nursing home residents by Oyebanji, Oladayo A., Abul, Yasin, Wilson, Brigid M., Bosch, Jurgen, Didion, Elise M., Paxitzis, Alexandra N., Sundheimer, Nicholas, Ragavapuram, Vaishnavi, Wilk, Dennis, Keresztesy, Debbie, Aung, Htin, Cao, Yi, King, Christopher L., Balazs, Alejandro B., White, Elizabeth M., Gravenstein, Stefan, Canaday, David H.

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Multi-modal profiling of human fetal liver hematopoietic stem cells reveals the molecular signature of engraftment by Vanuytsel, Kim, Villacorta-Martin, Carlos, Lindstrom-Vautrin, Jonathan, Wang, Zhe, Garcia-Beltran, Wilfredo F., Vrbanac, Vladimir, Parsons, Dylan, Lam, Evan C., Matte, Taylor M., Dowrey, Todd W., Kumar, Sara S., Li, Mengze, Wang, Feiya, Yeung, Anthony K., Mostoslavsky, Gustavo, Dries, Ruben, Campbell, Joshua D., Belkina, Anna C., Balazs, Alejandro B., Murphy, George J.

“…The human hematopoietic stem cell harbors remarkable regenerative potential that can be harnessed therapeutically. During early development, hematopoietic stem…”
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T cell-tropic HIV efficiently infects alveolar macrophages through contact with infected CD4+ T cells by Schiff, Abigail E., Linder, Alice H., Luhembo, Shillah N., Banning, Stephanie, Deymier, Martin J., Diefenbach, Thomas J., Dickey, Amy K., Tsibris, Athe M., Balazs, Alejandro B., Cho, Josalyn L., Medoff, Benjamin D., Walzl, Gerhard, Wilkinson, Robert J., Burgers, Wendy A., Corleis, Björn, Kwon, Douglas S.

“…Alveolar macrophages (AMs) are critical for defense against airborne pathogens and AM dysfunction is thought to contribute to the increased burden of pulmonary…”
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Rationally designed immunogens enable immune focusing following SARS-CoV-2 spike imprinting by Hauser, Blake M., Sangesland, Maya, St. Denis, Kerri J., Lam, Evan C., Case, James Brett, Windsor, Ian W., Feldman, Jared, Caradonna, Timothy M., Kannegieter, Ty, Diamond, Michael S., Balazs, Alejandro B., Lingwood, Daniel, Schmidt, Aaron G.

“…Eliciting antibodies to surface-exposed viral glycoproteins can generate protective responses that control and prevent future infections. Targeting conserved…”
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