Search Results - "Balasubrahmanyam, Budda"

Preclinical and first-in-human evaluation of AL002, a novel TREM2 agonistic antibody for Alzheimer's disease by Long, Hua, Simmons, Adam, Mayorga, Arthur, Burgess, Brady, Nguyen, Tuan, Budda, Balasubrahmanyam, Rychkova, Anna, Rhinn, Herve, Tassi, Ilaria, Ward, Michael, Yeh, Felix, Schwabe, Tina, Paul, Robert, Kenkare-Mitra, Sara, Rosenthal, Arnon

“…Variants of the gene triggering receptor expressed on myeloid cells-2 (TREM2) increase the risk of Alzheimer's disease (AD) and other neurodegenerative…”
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Phase 1 study of latozinemab in progranulin‐associated frontotemporal dementia by Ward, Michael, Carter, Lawrence P., Huang, Julie Y., Maslyar, Daniel, Budda, Balasubrahmanyam, Paul, Robert, Rosenthal, Arnon

“…INTRODUCTION Heterozygous mutations in the GRN gene lead to reduced progranulin (PGRN) levels in plasma and cerebrospinal fluid (CSF) and are causative of…”
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Population pharmacokinetic modeling of sotatercept in healthy participants and patients with pulmonary arterial hypertension by Ait‐Oudhia, Sihem, Jaworowicz, David, Hu, Ziheng, Bihorel, Sébastien, Hu, Shuai, Balasubrahmanyam, Budda, Mistry, Bipin, Oliveira Pena, Janethe, Wenning, Larissa, Gheyas, Ferdous

“…Sotatercept is a breakthrough, first‐in‐class biologic, that is FDA‐approved for the treatment of pulmonary arterial hypertension (PAH). A population…”
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Population Pharmacokinetics and Exposure–Response of Luspatercept, an Erythroid Maturation Agent, in Anemic Patients With Myelodysplastic Syndromes by Chen, Nianhang, Kassir, Nastya, Laadem, Abderrahmane, Maxwell, Stephen E., Sriraman, Priya, Giuseppi, Ana Carolina, Ritland, Steve, Linde, Peter G., Budda, Balasubrahmanyam, Reynolds, Joseph G., Zhou, Simon, Palmisano, Maria

“…Luspatercept is a recombinant fusion protein that enhances late‐stage erythroid maturation. This report describes the population pharmacokinetics and…”
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Repeat IV and SC Dosing of the Anti-Sortilin Antibody AL101 (P7-6.007) by Park, Lovingly, Maslyar, Daniel, Ward, Michael, Yeh, Felix, Long, Hua, Kurnellas, Michael, Vadhavkar, Mayura, Budda, Balasubrahmanyam

“…Abstract only…”
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Efflux transporters- and cytochrome P-450-mediated interactions between drugs of abuse and antiretrovirals by Pal, Dhananjay, Kwatra, Deep, Minocha, Mukul, Paturi, Durga K., Budda, Balasubrahmanyam, Mitra, Ashim K.

“…Multidrug regimens and corresponding drug interactions cause many adverse reactions and treatment failures. Drug efflux transporters: P-gp, MRP, BCRP in…”
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Population Pharmacokinetics and Exposure‐Response Relationship of Luspatercept, an Erythroid Maturation Agent, in Anemic Patients With β‐Thalassemia by Chen, Nianhang, Kassir, Nastya, Laadem, Abderrahmane, Giuseppi, Ana Carolina, Shetty, Jeevan, Maxwell, Stephen E., Sriraman, Priya, Ritland, Steve, Linde, Peter G., Budda, Balasubrahmanyam, Reynolds, Joseph G., Zhou, Simon, Palmisano, Maria

“…β‐Thalassemia is an inherited blood disorder resulting from defects in hemoglobin production, leading to premature death of red blood cells (RBCs) or their…”
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Role of efflux pumps and metabolising enzymes in drug delivery by Katragadda, Suresh, Budda, Balasubrahmanyam, Anand, Banmeet S, Mitra, Ashim K

“…The impact of efflux pumps and metabolic enzymes on the therapeutic activity of various drugs has been well established. The presence of efflux pumps on…”
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Biotin uptake and cellular translocation in human derived retinoblastoma cell line (Y-79): A role of hSMVT system by Kansara, Viral, Luo, Shuanghui, Balasubrahmanyam, Budda, Pal, Dhananjay, Mitra, Ashim K.

“…The objective of this research was to investigate the presence of a specialized carrier-mediated system for biotin and delineate uptake mechanism and…”
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In vitro models for simultaneous assessment of P -glycoprotein and CYP3A4 mediated drug interactions by Budda, Balasubrahmanyam

“…The findings of this project provided the crucial insights into the mechanistic basis of P-glycoprotein (P-gp), an MDR1 gene product and CYP3A4, a phase I…”
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In vitro models for simultaneous assessment of P-glycoprotein and CYP3A4 mediated drug interactions by Budda, Balasubrahmanyam

“…The findings of this project provided the crucial insights into the mechanistic basis of P-glycoprotein (P-gp), an MDR1 gene product and CYP3A4, a phase I…”
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