Search Results - "Balasco Serrão, Vitor Hugo"

Development of Antibiotics That Dysregulate the Neisserial ClpP Protease by Binepal, Gursonika, Mabanglo, Mark F, Goodreid, Jordan D, Leung, Elisa, Barghash, Marim M, Wong, Keith S, Lin, Funing, Cossette, Michele, Bansagi, Jazmin, Song, Boxi, Balasco Serrão, Vitor Hugo, Pai, Emil F, Batey, Robert A, Gray-Owen, Scott D, Houry, Walid A

“…Evolving antimicrobial resistance has motivated the search for novel targets and alternative therapies. Caseinolytic protease (ClpP) has emerged as an enticing…”
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Amyloid‑α Peptide Formed through Alternative Processing of the Amyloid Precursor Protein Attenuates Alzheimer’s Amyloid‑β Toxicity via Cross-Chaperoning by Kuhn, Ariel J., Chan, Ka, Sajimon, Maria, Yoo, Stan, Balasco Serrão, Vitor Hugo, Lee, Jack, Abrams, Benjamin, Nowick, James S., Uversky, Vladimir N., Wheeler, Christopher, Raskatov, Jevgenij A.

“…Amyloid aggregation is a key feature of Alzheimer’s disease (AD) and a primary target for past and present therapeutic efforts. Recent research is making it…”
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New Insights into Hsp90 Structural Plasticity Revealed by cryoEM by Minari, Karine, Balasco Serrão, Vitor Hugo, Borges, Júlio César

“…Heat Shock Protein 90 (Hsp90) acts as a crucial molecular chaperone, playing an essential role in activating numerous signaling proteins. The intricate…”
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The unique tRNASec and its role in selenocysteine biosynthesis by Serrão, Vitor Hugo Balasco, Silva, Ivan Rosa, da Silva, Marco Tulio Alves, Scortecci, Jéssica Fernandes, de Freitas Fernandes, Adriano, Thiemann, Otavio Henrique

“…Selenium (Se) is an essential trace element for several organisms and is mostly present in proteins as l -selenocysteine (Sec or U). Sec is synthesized on its…”
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Spectroscopic and calorimetric assays reveal dependence on dCTP and two metals (Zn2++Mg2+) for enzymatic activity of Schistosoma mansoni deoxycytidylate (dCMP) deaminase by Scortecci, Jéssica Fernandes, Serrão, Vitor Hugo Balasco, Cheleski, Juliana, Torini, Juliana Roberta, Romanello, Larissa, DeMarco, Ricardo, D'Muniz Pereira, Humberto

“…The parasite Schistosoma mansoni possess all pathways for pyrimidine biosynthesis, whereby deaminases play an essential role in the thymidylate cycle, a…”
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Schistosoma mansoni displays an adenine phosphoribosyltransferase preferentially expressed in mature female gonads and vitelaria by Zeraik, Ana Eliza, Balasco Serrão, Vitor Hugo, Romanello, Larissa, Torini, Juliana Roberta, Cassago, Alexandre, DeMarco, Ricardo, Pereira, Humberto D’Muniz

“…[Display omitted] •Adenine phosphoribosyltransferase 1 (APRT 1) is preferentially expressed in the female gonads.•S. mansoni possesses three different APRT…”
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Characterization of a Schistosoma mansoni NDPK expressed in sexual and digestive organs by Torini, Juliana Roberta, de Freitas Fernandes, Adriano, Balasco Serrão, Vitor Hugo, Romanello, Larissa, Bird, Louise E., Nettleship, Joanne E., Owens, Raymond J., Brandão-Neto, José, Zeraik, Ana Eliza, DeMarco, Ricardo, D’Muniz Pereira, Humberto

“…•Crystallographic structure of nucleoside diphosphate kinase (NDPK) from Schistosoma mansoni in two different space-group and in complex with ADP.•Kinetics…”
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Structure analysis of capsid protein of Porcine circovirus type 2 from pigs with systemic disease by Gava, Danielle, Serrão, Vitor Hugo Balasco, Fernandes, Lana Teixeira, Cantão, Mauricio Egídio, Ciacci-Zanella, Janice Reis, Morés, Nelson, Schaefer, Rejane

“…Economic losses with high mortality rate associated with Porcine circovirus type 2 (PCV2) is reported worldwide. PCV2 commercial vaccine was introduced in 2006…”
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Bacterial selenocysteine synthase structure revealed by single-particle cryoEM by Balasco Serrão, Vitor Hugo, Minari, Karine, Pereira, Humberto D'Muniz, Thiemann, Otavio Henrique

“…The 21st amino acid, selenocysteine (Sec), is synthesized on its dedicated transfer RNA (tRNASec). In bacteria, Sec is synthesized from Ser-tRNA[Ser]Sec by…”
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Why Selenocysteine Is Unique? by Serrão, Vitor Hugo Balasco, Scortecci, Jessica Fernandes

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The molecular structure of Schistosoma mansoni PNP isoform 2 provides insights into the nucleoside selectivity of PNPs by Torini, Juliana Roberta, Romanello, Larissa, Batista, Fernanda Aparecida Heleno, Serrão, Vitor Hugo Balasco, Faheem, Muhammad, Zeraik, Ana Eliza, Bird, Louise, Nettleship, Joanne, Reddivari, Yamini, Owens, Ray, DeMarco, Ricardo, Borges, Júlio César, Brandão-Neto, José, Pereira, Humberto D'Muniz

“…Purine nucleoside phosphorylases (PNPs) play an important role in the blood fluke parasite Schistosoma mansoni as a key enzyme of the purine salvage pathway…”
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Structural and kinetic analysis of Schistosoma mansoni Adenylosuccinate Lyase (SmADSL) by Romanello, Larissa, Serrão, Vitor Hugo Balasco, Torini, Juliana Roberta, Bird, Louise E., Nettleship, Joanne E., Rada, Heather, Reddivari, Yamini, Owens, Ray J., DeMarco, Ricardo, Brandão-Neto, José, Pereira, Humberto D’Muniz

“…•Crystal Structure of Adenylosuccinate Lyase Apo form and in complex with AMP from Schistosoma mansoni..•Analysis of the dimer interface and structural…”
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Assembly stoichiometry of bacterial selenocysteine synthase and SelC (tRNAsec) by Manzine, Livia Regina, Serrão, Vitor Hugo Balasco, Lima, Luis Maurício Trambaioli da Rocha e, de Souza, Marcos Michel, Bettini, Jefferson, Portugal, Rodrigo Villares, van Heel, Marin, Thiemann, Otavio Henrique

“…► SelA–tRNAsec binding stoichiometry of five tRNAsec per SelA decamer is incorrect. ► Direct and reverse fluorescence anisotropy show a stoichiometry of one…”
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Seryl-tRNA synthetase specificity for tRNASec in Bacterial Sec biosynthesis by de Freitas Fernandes, Adriano, Serrão, Vitor Hugo Balasco, Scortecci, Jéssica Fernandes, Thiemann, Otavio Henrique

“…tRNA synthetases are responsible for decoding the molecular information, from codons to amino acids. Seryl-tRNA synthetase (SerRS), besides the five…”
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The Specific Elongation Factor to Selenocysteine Incorporation in Escherichia coli: Unique tRNASec Recognition and its Interactions by Serrão, Vitor Hugo Balasco, Fernandes, Adriano de Freitas, Basso, Luis Guilherme Mansor, Scortecci, Jéssica Fernandes, Crusca Júnior, Edson, Cornélio, Marinônio Lopes, de Souza, Bibiana Monson, Palma, Mário Sérgio, de Oliveira Neto, Mario, Thiemann, Otavio Henrique

“…[Display omitted] •Elucidate the Sec incorporation pathway having SelB as checkpoint monitoring its interactions.•Determine the order of events in the…”
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New insights on human Hsp70-escort protein 1: Chaperone activity, interaction with liposomes, cellular localizations and HSPA's self-assemblies remodeling by Dores-Silva, Paulo Roberto, Kiraly, Vanessa Thomaz Rodrigues, Moritz, Milene Nóbrega de Oliveira, Serrão, Vitor Hugo Balasco, dos Passos, Patrícia Maria Siqueira, Spagnol, Valentine, Teixeira, Felipe Roberti, Gava, Lisandra Marques, Cauvi, David Mario, Ramos, Carlos Henrique Inácio, De Maio, Antonio, Borges, Júlio César

“…The 70 kDa heat shock proteins (Hsp70) are prone to self-assembly under thermal stress conditions, forming supramolecular assemblies (SMA), what may have…”
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Structure and kinetics assays of recombinant Schistosoma mansoni dihydrofolate reductase by Serrão, Vitor Hugo Balasco, Romanello, Larissa, Cassago, Alexandre, de Souza, Juliana Roberta Torini, Cheleski, Juliana, DeMarco, Ricardo, Brandão-Neto, José, Pereira, Humberto D’Muniz

“…•The structure of recombinant dihydrofolate reductase from S. mansoni (SmDHFR) was determined.•The kinetic and thermodynamic parameters of the catalytic…”
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In vitro and in vivo characterization of the multiple isoforms of Schistosoma mansoni hypoxanthine-guanine phosphoribosyltransferases by Romanello, Larissa, Zeraik, Ana Eliza, de Freitas Fernandes, Adriano, Torini, Juliana Roberta, Bird, Louise E., Nettleship, Joanne E., Rada, Heather, Reddivari, Yamini, Owens, Ray J., Serrão, Vitor Hugo Balasco, DeMarco, Ricardo, Brandão-Neto, José, Pereira, Humberto D'Muniz

“…•A crystal structure of Schistosoma mansoni HGPRT-1 (SmHGPRT), complexed with IMP at a resolution of 2.8 Ǻ is described.•RNA-Seq and WISH data, suggests that…”
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High-resolution reconstruction of a C. elegans ribosome sheds light on evolutionary dynamics and tissue specificity by Sehgal, Enisha, Wohlenberg, Chloe, Soukup, Evan M, Viscardi, Marcus J, Serrão, Vitor Hugo Balasco, Arribere, Joshua A

“…is an important model organism for human health and disease, with foundational contributions to the understanding of gene expression and tissue patterning in…”
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Analysis of two Schistosoma mansoni uridine phosphorylases isoforms suggests the emergence of a protein with a non-canonical function by da Silva Neto, Antônio Marinho, Torini de Souza, Juliana Roberta, Romanello, Larissa, Cassago, Alexandre, Serrão, Vitor Hugo Balasco, DeMarco, Ricardo, Brandão-Neto, José, Garratt, Richard Charles, Pereira, Humberto D'Muniz

“…Reports of Schistosoma mansoni strains resistant to praziquantel, the only therapeutic strategy available for the treatment of schistosomiasis, have motivated…”
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