Search Results - "Balas, A"

The ethics of practicing defensive medicine in Jordan: a diagnostic study by Al-Balas, Qosay A E, Al-Balas, Hassan A E

“…Defensive medicine (DM) practice refers to the ordering or prescription of unnecessary treatments or tests while avoiding risky procedures for critically ill…”
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Computational fragment-based drug design of potential Glo-I inhibitors by Bibars, Roaa S, Al-Balas, Qosay A

“…In this study, a fragment-based drug design approach, particularly drug design, was implemented utilising three different crystal structures in order to…”
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Molecular Dynamics Simulations of Adenosine Receptors: Advances, Applications and Trends by Al-Shar'i, Nizar A, Al-Balas, Qosay A

“…Adenosine receptors (ARs) are transmembrane proteins that belong to the G protein-coupled receptors (GPCRs) superfamily and mediate the biological functions of…”
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Haploidentical IL-15/41BBL activated and expanded natural killer cell infusion therapy after salvage chemotherapy in children with relapsed and refractory leukemia by Vela, M., Corral, D., Carrasco, P., Fernández, L., Valentín, J., González, B., Escudero, A., Balas, A., de Paz, R., Torres, J., Leivas, A., Martinez-Lopez, J., Pérez-Martínez, A.

“…Primary refractory or relapsed pediatric leukemia yield significant morbidity and mortality, with long-term survival rates <40%. Here we present a post-hoc…”
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Identification of the First "Two Digit Nano-molar" Inhibitors of the Human Glyoxalase-I Enzyme as Potential Anticancer Agents by Al-Balas, Qosay A, Al-Sha'er, Mahmoud A, Hassan, Mohammad A, Al Zou'bi, Esra'a

“…Glyoxalase-I (Glo-I) enzyme is recognized as an indispensable druggable target in cancer treatment. Its inhibition will lead to the accumulation of toxic…”
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SARS-CoV-2-Specific Memory T Lymphocytes From COVID-19 Convalescent Donors: Identification, Biobanking, and Large-Scale Production for Adoptive Cell Therapy by Ferreras, C, Pascual-Miguel, B, Mestre-Durán, C, Navarro-Zapata, A, Clares-Villa, L, Martín-Cortázar, C, De Paz, R, Marcos, A, Vicario, J L, Balas, A, García-Sánchez, F, Eguizabal, C, Solano, C, Mora-Rillo, M, Soria, B, Pérez-Martínez, A

“…Syndrome coronavirus 2 (SARS-CoV-2) pandemic is causing a second outbreak significantly delaying the hope for the virus' complete eradication. In the absence…”
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Design, synthesis and biological evaluation of novel glyoxalase I inhibitors possessing diazenylbenzenesulfonamide moiety as potential anticancer agents by Al-Oudat, Buthina A., Jaradat, Hana'a M., Al‑Balas, Qosay A., Al-Shar'i, Nizar A., Bryant-Friedrich, Amanda, Bedi, Mel F.

“…[Display omitted] The enzyme glyoxalase-I (Glo-I) is an essential therapeutic target in cancer treatment. Significant efforts have been made to discover…”
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Recent Advances in Glyoxalase-I Inhibition by Al-Balas, Qosay A, Hassan, Mohammad A, Al-Shar'i, Nizar A, Al Jabal, Ghazi A, Almaaytah, Ammar M

“…Glyoxalase system is a ubiquitous system in human cells which has been examined thoroughly for its role in different disease conditions. It is composed of…”
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An Ethical Roadmap for Prioritizing Medical Resources Within Muslim Societies During the COVID-19 Pandemic by Al-Balas, Qosay A. E., Al-Delaimy, Wael K.

“…Profound ethical challenges have been generated by the emergence of the COVID-19 pandemic. The unprecedented plights that have arisen have led nations to…”
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Computational and experimental exploration of the structure–activity relationships of flavonoids as potent glyoxalase‐I inhibitors by Al‐Balas, Qosay A., Hassan, Mohammad A., Al‐Shar'i, Nizar A., El‐Elimat, Tamam, Almaaytah, Ammar M.

“…Hit, Lead & Candidate Discovery Glyoxalase‐I (Glo‐I) enzyme has emerged as a potential target for cancer treatment. Several classes of natural products…”
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Multi-Armed 1,2,3-Selenadiazole and 1,2,3-Thiadiazole Benzene Derivatives as Novel Glyoxalase-I Inhibitors by Al-Balas, Qosay A, Al-Smadi, Mousa L, Hassan, Mohammad A, Al Jabal, Ghazi A, Almaaytah, Ammar M, Alzoubi, Karem H

“…Glyoxalase-I (Glo-I) enzyme was established to be a valid target for anticancer drug design. It performs the essential detoxification step of harmful…”
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Image-guided biopsy: what the interventional radiologist needs to know about PET/CT by Kobayashi, Katsuhiro, Bhargava, Peeyush, Raja, Shanker, Nasseri, Farbod, Al-Balas, Hassan A, Smith, Darryl D, George, Sharad P, Vij, Meena S

“…Positron emission tomography (PET)/computed tomography (CT) with fluorine 18 fluorodeoxyglucose (FDG) is increasingly used in evaluation of oncology patients…”
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Ellagic acid: A potent glyoxalase-I inhibitor with a unique scaffold by Al-Shar’i, Nizar A., Al-Balas, Qosay A., Hassan, Mohammad A., El-Elimat, Tamam M., Aljabal, Ghazi A., Almaaytah, Ammar M.

“…The glyoxalase system, particularly glyoxalase-I (GLO-I), has been approved as a potential target for cancer treatment. In this study, a set of structurally…”
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Genomic sequences of two novel HLA‐C alleles, HLA‐C15:143 and HLA‐C07:109:02 by Balas, A., García‐Sánchez, F., Alenda, R., Vicario, J. L.

“…Two novel HLA‐C alleles, C*07:109:02 and C*15:143, were characterized in two Spanish individuals…”
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The Ethics of Gene Editing from an Islamic Perspective: A Focus on the Recent Gene Editing of the Chinese Twins by Al-Balas, Qosay A. E., Dajani, Rana, Al-Delaimy, Wael K.

“…In light of the development of “CRISPR” technology, new promising advances in therapeutic and preventive approaches have become a reality. However, with it…”
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Identification of Human Leukotriene A4 Hydrolase Inhibitors Using Structure-Based Pharmacophore Modeling and Molecular Docking by Audat, Suaad A, Al-Shar'i, Nizar A, Al-Oudat, Buthina A, Bryant-Friedrich, Amanda, Bedi, Mel F, Zayed, Aref L, Al-Balas, Qosay A

“…Leukotriene B4 (LTB4) is a potent, proinflammatory lipid mediator implicated in the pathologies of an array of inflammatory diseases and cancer. The…”
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Production and Sensitivity Evaluation of Nanocrystalline RDX-based Explosive Compositions by Stepanov, Victor, Anglade, Venant, Balas Hummers, Wendy A., Bezmelnitsyn, Andrey V., Krasnoperov, Lev N.

“…The initiation sensitivity of cyclotrimethylenetrinitramine (RDX) was investigated as a function of crystal size. For this study, RDX powders with mean crystal…”
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RNA processing and protein expression of HLA‐B07:44N by Balas, A., García‐Sánchez, F., Vicario, J. L.

“…Background The assignment of human leukocyte antigen (HLA) null alleles is clinically relevant in the setting of stem cell transplantation. Cell surface…”
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Lead optimization and biological evaluation of diazenylbenzenesulfonamides inhibitors against glyoxalase-I enzyme as potential anticancer agents by Al-Oudat, Buthina A., Al-Shar'i, Nizar A., Al‑Balas, Qosay A., Audat, Suaad A., Alqudah, Mohammad A.Y., Hamzah, Ali H., Hallak, Ramez W., Bedi, Mel, Bryant-Friedrich, Amanda

“…[Display omitted] •Targeting the central zinc atom in the active site of glyoxalase I enzyme produces potent inhibitors.•Active inhibitors formed bidentate…”
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Genomic sequences of five novel HLA class I alleles: A30:129, B08:195, B51:01:62, C01:147 and C12:195:02 by Balas, A., Alenda, R., Moreno‐Hidalgo, M. A., García‐Sánchez, F., Vicario, J. L.

“…Five new HLA class I alleles are described, A*30:129, B*08:195, B*51:01:62, C*01:147 and C*12:195:02…”
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