Search Results - "Balachandran, Harikrishnan"

NK cells modulate in vivo control of SARS-CoV-2 replication and suppression of lung damage by Balachandran, Harikrishnan, Kroll, Kyle, Terry, Karen, Manickam, Cordelia, Jones, Rhianna, Woolley, Griffin, Hayes, Tammy, Martinot, Amanda J, Sharma, Ankur, Lewis, Mark, Jost, Stephanie, Reeves, R Keith

“…Natural killer (NK) cells play a critical role in virus control. However, it has remained largely unclear whether NK cell mobilization in SARS-CoV-2 infections…”
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Pathogenic infection of Rhesus macaques by an evolving SIV-HIV derived from CCR5-using envelope genes of acute HIV-1 infections by Asmal, Mohammed, Lane, Sophie, Tian, Meijuan, Nickel, Gabrielle, Venner, Colin, Dirk, Brennan, Dikeakos, Jimmy, Luedemann, Corinne, Mach, Linh, Balachandran, Harikrishnan, Buzby, Adam, Rao, Srinivas, Letvin, Norman, Gao, Yong, Arts, Eric J

“…Abstract For studies on vaccines and therapies for HIV disease, SIV-HIV chimeric viruses harboring the HIV-1 env gene (SHIVenv) remain the best virus in…”
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Recombinant Mycobacterium bovis BCG Prime-Recombinant Adenovirus Boost Vaccination in Rhesus Monkeys Elicits Robust Polyfunctional Simian Immunodeficiency Virus-Specific T-Cell Responses by Cayabyab, Mark J., Korioth-Schmitz, Birgit, Sun, Yue, Carville, Angela, Balachandran, Harikrishnan, Miura, Ayako, Carlson, Kevin R., Buzby, Adam P., Haynes, Barton F., Jacobs, William R., Letvin, Norman L.

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Activation of the p38 Map kinase pathway is essential for the antileukemic effects of dasatinib by Dumka, Disha, Puri, Poonam, Carayol, Nathalie, Lumby, Crystal, Balachandran, Harikrishnan, Schuster, Katja, Verma, Amit K., Terada, Lance S., Platanias, Leonidas C., Parmar, Simrit

“…Dasatinib, a dual Src/Abl tyrosine kinase inhibitor, has significant antileukemic effects against various imatinib mesylate-resistant BCR/ABL mutants. Despite…”
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Recombinant Mycobacterium bovis bacillus Calmette-Guérin vectors prime for strong cellular responses to simian immunodeficiency virus gag in rhesus macaques by Sixsmith, Jaimie D, Panas, Michael W, Lee, Sunhee, Gillard, Geoffrey O, White, KeriAnn, Lifton, Michelle A, Balachandran, Harikrishnan, Mach, Linh, Miller, John P, Lavine, Christy, DeMarco, C Todd, Tomaras, Georgia D, Gee, Connie, Porcelli, Steven A, Larsen, Michelle H, Frothingham, Richard, Schmitz, Joern E, Jacobs, Jr, William R, Haynes, Barton F, Letvin, Norman L, Korioth-Schmitz, Birgit

“…Live attenuated nonpathogenic Mycobacterium bovis bacillus Calmette-Guérin (BCG) mediates long-lasting immune responses, has been safely administered as a…”
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Vaccination Reduces Simian-Human Immunodeficiency Virus Sequence Reversion through Enhanced Viral Control by MANUEL, Edwin R, YEH, Wendy W, BALACHANDRAN, Harikrishnan, CLARKE, Ryon H, LIFTON, Michelle A, LETVIN, Norman L

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Immunizations with diverse sarbecovirus receptor-binding domains elicit SARS-CoV-2 neutralizing antibodies against a conserved site of vulnerability by Burnett, Deborah L., Jackson, Katherine J.L., Langley, David B., Aggarwal, Anupriya, Stella, Alberto Ospina, Johansen, Matt D., Balachandran, Harikrishnan, Lenthall, Helen, Rouet, Romain, Walker, Gregory, Saunders, Bernadette M., Singh, Mandeep, Li, Hui, Henry, Jake Y., Jackson, Jennifer, Stewart, Alastair G., Witthauer, Franka, Spence, Matthew A., Hansbro, Nicole G., Jackson, Colin, Schofield, Peter, Milthorpe, Claire, Martinello, Marianne, Schulz, Sebastian R., Roth, Edith, Kelleher, Anthony, Emery, Sean, Britton, Warwick J., Rawlinson, William D., Karl, Rudolfo, Schäfer, Simon, Winkler, Thomas H., Brink, Robert, Bull, Rowena A., Hansbro, Philip M., Jäck, Hans-Martin, Turville, Stuart, Christ, Daniel, Goodnow, Christopher C.

“…Viral mutations are an emerging concern in reducing SARS-CoV-2 vaccination efficacy. Second-generation vaccines will need to elicit neutralizing antibodies…”
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FcαRI (CD89) is upregulated on subsets of mucosal and circulating NK cells and regulates IgA-class specific signaling and functions by Kroll, Kyle W., Hueber, Brady, Balachandran, Harikrishnan, Afifi, Ameera, Manickam, Cordelia, Nettere, Danielle, Pollara, Justin, Hudson, Andrew, Woolley, Griffin, Ndhlovu, Lishomwa C., Reeves, R. Keith

“…Immunoglobulin A (IgA) is the predominant mucosal antibody class with both anti- and pro-inflammatory roles1–3. However, the specific role of the IgA receptor…”
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Broadly neutralizing SARS-CoV-2 antibodies through epitope-based selection from convalescent patients by Rouet, Romain, Henry, Jake Y., Johansen, Matt D., Sobti, Meghna, Balachandran, Harikrishnan, Langley, David B., Walker, Gregory J., Lenthall, Helen, Jackson, Jennifer, Ubiparipovic, Stephanie, Mazigi, Ohan, Schofield, Peter, Burnett, Deborah L., Brown, Simon H. J., Martinello, Marianne, Hudson, Bernard, Gilroy, Nicole, Post, Jeffrey J., Kelleher, Anthony, Jäck, Hans-Martin, Goodnow, Christopher C., Turville, Stuart G., Rawlinson, William D., Bull, Rowena A., Stewart, Alastair G., Hansbro, Philip M., Christ, Daniel

“…Emerging variants of concern (VOCs) are threatening to limit the effectiveness of SARS-CoV-2 monoclonal antibodies and vaccines currently used in clinical…”
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Maintenance of broad neutralizing antibodies and memory B cells 1 year post-infection is predicted by SARS-CoV-2-specific CD4+ T cell responses by Balachandran, Harikrishnan, Phetsouphanh, Chansavath, Agapiou, David, Adhikari, Anurag, Rodrigo, Chaturaka, Hammoud, Mohamed, Shrestha, Lok Bahadur, Keoshkerian, Elizabeth, Gupta, Money, Turville, Stuart, Christ, Daniel, King, Cecile, Sasson, Sarah C., Bartlett, Adam, Grubor-Bauk, Branka, Rawlinson, William, Aggarwal, Anupriya, Stella, Alberto Ospina, Klemm, Vera, Mina, Michael M., Post, Jeffrey J., Hudson, Bernard, Gilroy, Nicky, Konecny, Pam, Ahlenstiel, Golo, Dwyer, Dominic E., Sorrell, Tania C., Kelleher, Anthony, Tedla, Nicodemus, Lloyd, Andrew R., Martinello, Marianne, Bull, Rowena A.

“…Understanding the long-term maintenance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunity is critical for predicting protection against…”
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Mosaic vaccines elicit CD8 + T lymphocyte responses that confer enhanced immune coverage of diverse HIV strains in monkeys by Letvin, Norman L, Santra, Sampa, Liao, Hua-Xin, Zhang, Ruijin, Muldoon, Mark, Watson, Sydeaka, Fischer, Will, Theiler, James, Szinger, James, Balachandran, Harikrishnan, Buzby, Adam, Quinn, David, Parks, Robert J, Tsao, Chun-Yen, Carville, Angela, Mansfield, Keith G, Pavlakis, George N, Felber, Barbara K, Haynes, Barton F, Korber, Bette T

“…An effective HIV vaccine must elicit immune responses that recognize genetically diverse viruses. It must generate CD8+ T lymphocytes that control HIV…”
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High activation levels maintained in receptor‐binding domain–specific memory B cells in people with severe coronavirus disease 2019 by Gupta, Money, Balachandran, Harikrishnan, Louie, Raymond H Y, Li, Hui, Agapiou, David, Keoshkerian, Elizabeth, Christ, Daniel, Rawlinson, William, Mina, Michael M, Post, Jeffrey J, Hudson, Bernard, Gilroy, Nicky, Konecny, Pamela, Bartlett, Adam W, Sasson, Sarah C, Ahlenstiel, Golo, Dwyer, Dominic, Lloyd, Andrew R, Martinello, Marianne, Luciani, Fabio, Bull, Rowena A

“…The long‐term health consequences of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection are still being understood. The molecular and…”
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Immunization with an SIV-based IDLV Expressing HIV-1 Env 1086 Clade C Elicits Durable Humoral and Cellular Responses in Rhesus Macaques by Negri, Donatella, Blasi, Maria, LaBranche, Celia, Parks, Robert, Balachandran, Harikrishnan, Lifton, Michelle, Shen, Xiaoying, Denny, Thomas, Ferrari, Guido, Vescio, Maria Fenicia, Andersen, Hanne, Montefiori, David C, Tomaras, Georgia D, Liao, Hua-Xin, Santra, Sampa, Haynes, Barton F, Klotman, Mary E, Cara, Andrea

“…The design of an effective HIV-1 vaccine remains a major challenge. Several vaccine strategies based on viral vectors have been evaluated in preclinical and…”
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Long-term persistence of RBD+ memory B cells encoding neutralizing antibodies in SARS-CoV-2 infection by Abayasingam, Arunasingam, Balachandran, Harikrishnan, Agapiou, David, Hammoud, Mohamed, Rodrigo, Chaturaka, Keoshkerian, Elizabeth, Li, Hui, Brasher, Nicholas A., Christ, Daniel, Rouet, Romain, Burnet, Deborah, Grubor-Bauk, Branka, Rawlinson, William, Turville, Stuart, Aggarwal, Anupriya, Stella, Alberto Ospina, Fichter, Christina, Brilot, Fabienne, Mina, Michael, Post, Jeffrey J., Hudson, Bernard, Gilroy, Nicky, Dwyer, Dominic, Sasson, Sarah C., Tea, Fiona, Pilli, Deepti, Kelleher, Anthony, Tedla, Nicodemus, Lloyd, Andrew R., Martinello, Marianne, Bull, Rowena A.

“…Considerable concerns relating to the duration of protective immunity against severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) exist, with evidence…”
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Immune and Genetic Correlates of Vaccine Protection Against Mucosal Infection by SIV in Monkeys by Letvin, Norman L, Rao, Srinivas S, Montefiori, David C, Seaman, Michael S, Sun, Yue, Lim, So-Yon, Yeh, Wendy W, Asmal, Mohammed, Gelman, Rebecca S, Shen, Ling, Whitney, James B, Seoighe, Cathal, Lacerda, Miguel, Keating, Sheila, Norris, Philip J, Hudgens, Michael G, Gilbert, Peter B, Buzby, Adam P, Mach, Linh V, Zhang, Jinrong, Balachandran, Harikrishnan, Shaw, George M, Schmidt, Stephen D, Todd, John-Paul, Dodson, Alan, Mascola, John R, Nabel, Gary J

“…The RV144 vaccine trial in Thailand demonstrated that an HIV vaccine could prevent infection in humans and highlights the importance of understanding…”
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Comparison of Immunogenicity in Rhesus Macaques of Transmitted-Founder, HIV-1 Group M Consensus, and Trivalent Mosaic Envelope Vaccines Formulated as a DNA Prime, NYVAC, and Envelope Protein Boost by Hulot, Sandrine L, Korber, Bette, Giorgi, Elena E, Vandergrift, Nathan, Saunders, Kevin O, Balachandran, Harikrishnan, Mach, Linh V, Lifton, Michelle A, Pantaleo, Giuseppe, Tartaglia, Jim, Phogat, Sanjay, Jacobs, Bertram, Kibler, Karen, Perdiguero, Beatriz, Gomez, Carmen E, Esteban, Mariano, Rosati, Margherita, Felber, Barbara K, Pavlakis, George N, Parks, Robert, Lloyd, Krissey, Sutherland, Laura, Scearce, Richard, Letvin, Norman L, Seaman, Michael S, Alam, S Munir, Montefiori, David, Liao, Hua-Xin, Haynes, Barton F, Santra, Sampa

“…An effective human immunodeficiency virus type 1 (HIV-1) vaccine must induce protective antibody responses, as well as CD4(+) and CD8(+) T cell responses, that…”
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SARS-CoV-2 Omicron variant escapes neutralizing antibodies and T cell responses more efficiently than other variants in mild COVID-19 convalescents by Garcia-Valtanen, Pablo, Hope, Christopher M., Masavuli, Makutiro G., Yeow, Arthur Eng Lip, Balachandran, Harikrishnan, Mekonnen, Zelalem A., Al-Delfi, Zahraa, Abayasingam, Arunasingam, Agapiou, David, Stella, Alberto Ospina, Aggarwal, Anupriya, Bouras, George, Gummow, Jason, Ferguson, Catherine, O’Connor, Stephanie, McCartney, Erin M., Lynn, David J., Maddern, Guy, Gowans, Eric J., Reddi, Benjamin A.J., Shaw, David, Kok-Lim, Chuan, Beard, Michael R., Weiskopf, Daniela, Sette, Alessandro, Turville, Stuart G., Bull, Rowena A., Barry, Simon C., Grubor-Bauk, Branka

“…Coronavirus disease 2019 (COVID-19) convalescents living in regions with low vaccination rates rely on post-infection immunity for protection against…”
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Breadth of cellular and humoral immune responses elicited in rhesus monkeys by multi-valent mosaic and consensus immunogens by Santra, Sampa, Muldoon, Mark, Watson, Sydeaka, Buzby, Adam, Balachandran, Harikrishnan, Carlson, Kevin R, Mach, Linh, Kong, Wing-Pui, McKee, Krisha, Yang, Zhi-Yong, Rao, Srinivas S, Mascola, John R, Nabel, Gary J, Korber, Bette T, Letvin, Norman L

“…Abstract To create an HIV-1 vaccine that generates sufficient breadth of immune recognition to protect against the genetically diverse forms of the circulating…”
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Immunogenicity of NYVAC Prime-Protein Boost Human Immunodeficiency Virus Type 1 Envelope Vaccination and Simian-Human Immunodeficiency Virus Challenge of Nonhuman Primates by Saunders, Kevin O, Santra, Sampa, Parks, Robert, Yates, Nicole L, Sutherland, Laura L, Scearce, Richard M, Balachandran, Harikrishnan, Bradley, Todd, Goodman, Derrick, Eaton, Amanda, Stanfield-Oakley, Sherry A, Tartaglia, James, Phogat, Sanjay, Pantaleo, Giuseppe, Esteban, Mariano, Gomez, Carmen E, Perdiguero, Beatriz, Jacobs, Bertram, Kibler, Karen, Korber, Bette, Montefiori, David C, Ferrari, Guido, Vandergrift, Nathan, Liao, Hua-Xin, Tomaras, Georgia D, Haynes, Barton F

“…A preventive human immunodeficiency virus type 1 (HIV-1) vaccine is an essential part of the strategy to eradicate AIDS. A critical question is whether…”
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Infection of monkeys by simian-human immunodeficiency viruses with transmitted/founder clade C HIV-1 envelopes by Asmal, Mohammed, Luedemann, Corinne, Lavine, Christy L, Mach, Linh V, Balachandran, Harikrishnan, Brinkley, Christie, Denny, Thomas N, Lewis, Mark G, Anderson, Hanne, Pal, Ranajit, Sok, Devin, Le, Khoa, Pauthner, Matthias, Hahn, Beatrice H, Shaw, George M, Seaman, Michael S, Letvin, Norman L, Burton, Dennis R, Sodroski, Joseph G, Haynes, Barton F, Santra, Sampa

“…Abstract Simian-human immunodeficiency viruses (SHIVs) that mirror natural transmitted/founder (T/F) viruses in man are needed for evaluation of HIV-1 vaccine…”
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