Search Results - "Balabanian, Karl"

CXCR2 intrinsically drives the maturation and function of neutrophils in mice by Delobel, Pauline, Ginter, Benjamin, Rubio, Eliane, Balabanian, Karl, Lazennec, Gwendal

“…Neutrophils play a major role in the protection from infections but also in inflammation related to tumor microenvironment. However, cell-extrinsic and…”
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Genomic landscape of MDS/CMML associated with systemic inflammatory and autoimmune disease by Zhao, Lin-Pierre, Boy, Maxime, Azoulay, Célia, Clappier, Emmanuelle, Sébert, Marie, Amable, Ludivine, Klibi, Jihene, Benlagha, Kamel, Espéli, Marion, Balabanian, Karl, Preudhomme, Claude, Marceau-Renaut, Alice, Benajiba, Lina, Itzykson, Raphaël, Mekinian, Arsène, Fain, Olivier, Toubert, Antoine, Fenaux, Pierre, Dulphy, Nicolas, Adès, Lionel

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Hematopoietic Multipotent Progenitors and Plasma Cells: Neighbors or Roommates in the Mouse Bone Marrow Ecosystem? by Bonaud, Amélie, Lemos, Julia P, Espéli, Marion, Balabanian, Karl

“…The bone marrow is a complex ecosystem in which hematopoietic and non-hematopoietic cells reside. In this review, we discuss the bone marrow niches in mice…”
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The Chemokine SDF-1/CXCL12 Binds to and Signals through the Orphan Receptor RDC1 in T Lymphocytes by Balabanian, Karl, Lagane, Bernard, Infantino, Simona, Chow, Ken Y.C., Harriague, Julie, Moepps, Barbara, Arenzana-Seisdedos, Fernando, Thelen, Marcus, Bachelerie, Françoise

“…Combined phylogenetic and chromosomal location studies suggest that the orphan receptor RDC1 is related to CXC chemokine receptors. RDC1 provides a co-receptor…”
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CXCR4 hyperactivation cooperates with TCL1 in CLL development and aggressiveness by Lewis, Richard, Maurer, H. Carlo, Singh, Nikita, Gonzalez-Menendez, Irene, Wirth, Matthias, Schick, Markus, Zhang, Le, Isaakidis, Konstandina, Scherger, Anna Katharina, Schulze, Veronika, Lu, Junyan, Zenz, Thorsten, Steiger, Katja, Rad, Roland, Quintanilla-Martinez, Leticia, Espeli, Marion, Balabanian, Karl, Keller, Ulrich, Habringer, Stefan

“…Aberrant CXCR4 activity has been implicated in lymphoma pathogenesis, disease progression, and resistance to therapies. Using a mouse model with a…”
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Myelodysplastic Syndrome associated TET2 mutations affect NK cell function and genome methylation by Boy, Maxime, Bisio, Valeria, Zhao, Lin-Pierre, Guidez, Fabien, Schell, Bérénice, Lereclus, Emilie, Henry, Guylaine, Villemonteix, Juliette, Rodrigues-Lima, Fernando, Gagne, Katia, Retiere, Christelle, Larcher, Lise, Kim, Rathana, Clappier, Emmanuelle, Sebert, Marie, Mekinian, Arsène, Fain, Olivier, Caignard, Anne, Espeli, Marion, Balabanian, Karl, Toubert, Antoine, Fenaux, Pierre, Ades, Lionel, Dulphy, Nicolas

“…Myelodysplastic syndromes (MDS) are clonal hematopoietic disorders, representing high risk of progression to acute myeloid leukaemia, and frequently associated…”
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Neutrophil mobilization via plerixafor-mediated CXCR4 inhibition arises from lung demargination and blockade of neutrophil homing to the bone marrow by Devi, Sapna, Wang, Yilin, Chew, Weng Keong, Lima, Ronald, A-González, Noelia, Mattar, Citra N Z, Chong, Shu Zhen, Schlitzer, Andreas, Bakocevic, Nadja, Chew, Samantha, Keeble, Jo L, Goh, Chi Ching, Li, Jackson L Y, Evrard, Maximilien, Malleret, Benoit, Larbi, Anis, Renia, Laurent, Haniffa, Muzlifah, Tan, Suet Mien, Chan, Jerry K Y, Balabanian, Karl, Nagasawa, Takashi, Bachelerie, Françoise, Hidalgo, Andrés, Ginhoux, Florent, Kubes, Paul, Ng, Lai Guan

“…Blood neutrophil homeostasis is essential for successful host defense against invading pathogens. Circulating neutrophil counts are positively regulated by…”
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Potential role of estrogen receptor beta as a tumor suppressor of epithelial ovarian cancer by Bossard, Carine, Busson, Muriel, Vindrieux, David, Gaudin, Françoise, Machelon, Véronique, Brigitte, Madly, Jacquard, Carine, Pillon, Arnaud, Balaguer, Patrick, Balabanian, Karl, Lazennec, Gwendal

“…Ovarian cancer is the gynecological cancer exhibiting the highest morbidity and improvement of treatments is still required. Previous studies have shown that…”
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CXCR4 antagonism ameliorates leukocyte abnormalities in a preclinical model of WHIM syndrome by Roland, Lilian, Nguyen, Chi Huu, Zmajkovicova, Katarina, Khamyath, Mélanie, Kalogeraki, Maria, Schell, Bérénice, Gourhand, Vanessa, Rondeau, Vincent, Abou Nader, Zeina, Monticelli, Halenya, Maierhofer, Barbara, Johnson, Robert, Taveras, Arthur, Espéli, Marion, Balabanian, Karl

“…Background WHIM (Warts, Hypogammaglobulinemia, Infections, and Myelokathexis) syndrome is an ultra-rare, combined primary immunodeficiency and chronic…”
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Proper desensitization of CXCR4 is required for lymphocyte development and peripheral compartmentalization in mice by Balabanian, Karl, Brotin, Emilie, Biajoux, Vincent, Bouchet-Delbos, Laurence, Lainey, Elodie, Fenneteau, Odile, Bonnet, Dominique, Fiette, Laurence, Emilie, Dominique, Bachelerie, Françoise

“…Desensitization controls G protein–dependent signaling of chemokine receptors. We investigate the physiologic implication of this process for CXCR4 in a mouse…”
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Lymphoid differentiation of hematopoietic stem cells requires efficient Cxcr4 desensitization by Freitas, Christelle, Wittner, Monika, Nguyen, Julie, Rondeau, Vincent, Biajoux, Vincent, Aknin, Marie-Laure, Gaudin, Françoise, Beaussant-Cohen, Sarah, Bertrand, Yves, Bellanné-Chantelot, Christine, Donadieu, Jean, Bachelerie, Françoise, Espéli, Marion, Dalloul, Ali, Louache, Fawzia, Balabanian, Karl

“…The CXCL12/CXCR4 signaling exerts a dominant role in promoting hematopoietic stem and progenitor cell (HSPC) retention and quiescence in bone marrow…”
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Inflammation is predictive of outcome in Waldenström macroglobulinemia treated by Bruton tyrosine kinase inhibitors: a multicentric real-life study by Debureaux, Pierre-Edouard, Forgeard, Nathalie, Elessa, Dikelele, Harel, Stéphanie, Frenzel, Laurent, Royer, Bruno, Talbot, Alexis, Choquet, Sylvain, Davi, Frederic, Nguyen-Khac, Florence, Cuccuini, Wendy, Cheminant, Morgane, Bravetti, Clotilde, Lazarian, Gregory, Kaltenbach, Sophie, Hermine, Olivier, Roos-Weil, Damien, Espéli, Marion, Balabanian, Karl, Arnulf, Bertrand

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Efficient Plasma Cell Differentiation and Trafficking Require Cxcr4 Desensitization by Biajoux, Vincent, Natt, Jessica, Freitas, Christelle, Alouche, Nagham, Sacquin, Antoine, Hemon, Patrice, Gaudin, Françoise, Fazilleau, Nicolas, Espéli, Marion, Balabanian, Karl

“…CXCR4 plays a central role in B cell immune response, notably by promoting plasma cell (PC) migration and maintenance in the bone marrow (BM). Gain-of-function…”
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Deciphering Tumor Niches: Lessons From Solid and Hematological Malignancies by Mancini, Stéphane J C, Balabanian, Karl, Corre, Isabelle, Gavard, Julie, Lazennec, Gwendal, Le Bousse-Kerdilès, Marie-Caroline, Louache, Fawzia, Maguer-Satta, Véronique, Mazure, Nathalie M, Mechta-Grigoriou, Fatima, Peyron, Jean-François, Trichet, Valérie, Herault, Olivier

“…Knowledge about the hematopoietic niche has evolved considerably in recent years, in particular through analyzes, mouse models and the use of xenografts. Its…”
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Continuous MYD88 Activation Is Associated With Expansion and Then Transformation of IgM Differentiating Plasma Cells by Ouk, Catherine, Roland, Lilian, Gachard, Nathalie, Poulain, Stéphanie, Oblet, Christelle, Rizzo, David, Saintamand, Alexis, Lemasson, Quentin, Carrion, Claire, Thomas, Morgane, Balabanian, Karl, Espéli, Marion, Parrens, Marie, Soubeyran, Isabelle, Boulin, Mélanie, Faumont, Nathalie, Feuillard, Jean, Vincent-Fabert, Christelle

“…Activating mutations of ( being the far most frequent) are found in most cases of Waldenström macroglobulinemia (WM) as well as in various aggressive B-cell…”
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Identification of the chemokine CX3CL1 as a new regulator of malignant cell proliferation in epithelial ovarian cancer by Gaudin, Françoise, Nasreddine, Salam, Donnadieu, Anne-Claire, Emilie, Dominique, Combadière, Christophe, Prévot, Sophie, Machelon, Véronique, Balabanian, Karl

“…Little is known about the molecules that contribute to the growth of epithelial ovarian carcinomas (EOC), which remain the most lethal gynecological cancer in…”
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Description and outcome of a cohort of 8 patients with WHIM syndrome from the French Severe Chronic Neutropenia Registry by Beaussant Cohen, Sarah, Fenneteau, Odile, Plouvier, Emmanuel, Rohrlich, Pierre-Simon, Daltroff, Gerard, Plantier, Isabelle, Dupuy, Alain, Kerob, Delphine, Beaupain, Blandine, Bordigoni, Pierre, Fouyssac, Fanny, Delezoide, Anne-Lise, Devouassoux, Gilles, Nicolas, Jean François, Bensaid, Philippe, Bertrand, Yves, Balabanian, Karl, Chantelot, Christine Bellanne, Bachelerie, Françoise, Donadieu, Jean

“…WHIM syndrome (WS), a rare congenital neutropenia due to mutations of the CXCR4 chemokine receptor, is associated with Human Papillomavirus (HPV)-induced…”
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S1PR5 is pivotal for the homeostasis of patrolling monocytes by Debien, Emilie, Mayol, Katia, Biajoux, Vincent, Daussy, Cécile, De Aguero, Mercedes Gomez, Taillardet, Morgan, Dagany, Nicolas, Brinza, Lilia, Henry, Thomas, Dubois, Bertrand, Kaiserlian, Dominique, Marvel, Jacqueline, Balabanian, Karl, Walzer, Thierry

“…Patrolling Ly6C− monocytes are blood‐circulating cells that play a role in inflammation and in the defense against pathogens. Here, we show that similar to…”
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Semaphorin 3F and neuropilin-2 control the migration of human T-cell precursors by Mendes-da-Cruz, Daniella Arêas, Brignier, Anne Colette, Asnafi, Vahid, Baleydier, Frederic, Messias, Carolina Valença, Lepelletier, Yves, Bedjaoui, Nawel, Renand, Amedée, Smaniotto, Salete, Canioni, Danielle, Milpied, Pierre, Balabanian, Karl, Bousso, Philippe, Leprêtre, Stéphane, Bertrand, Yves, Dombret, Hervé, Ifrah, Norbert, Dardenne, Mireille, Macintyre, Elizabeth, Savino, Wilson, Hermine, Olivier

“…Neuropilins and semaphorins are known as modulators of axon guidance, angiogenesis, and organogenesis in the developing nervous system, but have been recently…”
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Lymphopenia confers poorer prognosis in Myelodysplastic Syndromes with very low and low IPSS-M by Fandrei, David, Huynh, Tony, Sébert, Marie, Aguinaga, Lorea, Bisio, Valeria, Kim, Rathana, Clappier, Emmanuelle, Espéli, Marion, Balabanian, Karl, Moins-Teisserenc, Hélène, Toubert, Antoine, Dulphy, Nicolas, Fenaux, Pierre, Adès, Lionel, Zhao, Lin-Pierre

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