Search Results - "Bakshi, Suruchi"

The Centrosome-Specific Phosphorylation of Cnn by Polo/Plk1 Drives Cnn Scaffold Assembly and Centrosome Maturation by Conduit, Paul T., Feng, Zhe, Richens, Jennifer H., Baumbach, Janina, Wainman, Alan, Bakshi, Suruchi D., Dobbelaere, Jeroen, Johnson, Steven, Lea, Susan M., Raff, Jordan W.

“…Centrosomes are important cell organizers. They consist of a pair of centrioles surrounded by pericentriolar material (PCM) that expands dramatically during…”
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The interaction of core modules as a basis for elucidating network behavior determining Parkinson's disease pathogenesis by Menon, Govind, Bakshi, Suruchi, Krishnan, J.

“…INTRODUCTION Parkinson's disease is multifactorial, with variability in its pathogenesis/progression and no cure yet. 1–4 This motivates the need to carefully…”
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Minimal brain PBPK model to support the preclinical and clinical development of antibody therapeutics for CNS diseases by Bloomingdale, Peter, Bakshi, Suruchi, Maass, Christian, van Maanen, Eline, Pichardo-Almarza, Cesar, Yadav, Daniela Bumbaca, van der Graaf, Piet, Mehrotra, Nitin

“…There are several antibody therapeutics in preclinical and clinical development, industry-wide, for the treatment of central nervous system (CNS) disorders…”
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A Review of Quantitative Systems Pharmacology Models of the Coagulation Cascade: Opportunities for Improved Usability by Chung, Douglas, Bakshi, Suruchi, van der Graaf, Piet H

“…Despite the numerous therapeutic options to treat bleeding or thrombosis, a comprehensive quantitative mechanistic understanding of the effects of these and…”
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A Generic Multi-Compartmental CNS Distribution Model Structure for 9 Drugs Allows Prediction of Human Brain Target Site Concentrations by Yamamoto, Yumi, Välitalo, Pyry A., van den Berg, Dirk-Jan, Hartman, Robin, van den Brink, Willem, Wong, Yin Cheong, Huntjens, Dymphy R., Proost, Johannes H., Vermeulen, An, Krauwinkel, Walter, Bakshi, Suruchi, Aranzana-Climent, Vincent, Marchand, Sandrine, Dahyot-Fizelier, Claire, Couet, William, Danhof, Meindert, van Hasselt, Johan G. C., de Lange, Elizabeth C. M.

“…Purpose Predicting target site drug concentration in the brain is of key importance for the successful development of drugs acting on the central nervous…”
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Correction to: Mathematical Modelling of Alternative Pathway of Complement System by Bakshi, Suruchi, Cunningham, Fraser, Nichols, Eva-Maria, Biedzka-Sarek, Marta, Neisen, Jessica, Petit-Frere, Sebastien, Bessant, Christina, Bansal, Loveleena, Peletier, Lambertus A., Zamuner, Stefano, van der Graaf, Piet H.

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Mathematical Modelling of Alternative Pathway of Complement System by Bakshi, Suruchi, Cunningham, Fraser, Nichols, Eva-Maria, Biedzka-Sarek, Marta, Neisen, Jessica, Petit-Frere, Sebastien, Bessant, Christina, Bansal, Loveleena, Peletier, Lambertus A., Zamuner, Stefano, van der Graaf, Piet H.

“…The complement system (CS) is an integral part of innate immunity and can be activated via three different pathways. The alternative pathway (AP) has a central…”
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Hallmarks of neurodegenerative disease: A systems pharmacology perspective by Bloomingdale, Peter, Karelina, Tatiana, Ramakrishnan, Vidya, Bakshi, Suruchi, Véronneau‐Veilleux, Florence, Moye, Matthew, Sekiguchi, Kazutaka, Meno‐Tetang, Guy, Mohan, Aparna, Maithreye, R., Thomas, Veena A., Gibbons, Frank, Cabal, Antonio, Bouteiller, Jean‐Marie, Geerts, Hugo

“…Age‐related central neurodegenerative diseases, such as Alzheimer's and Parkinson's disease, are a rising public health concern and have been plagued by…”
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Model-Based Optimisation of Deferoxamine Chelation Therapy by Bellanti, Francesco, Del Vecchio, Giovanni C., Putti, Maria C., Cosmi, Carlo, Fotzi, Ilaria, Bakshi, Suruchi D., Danhof, Meindert, Della Pasqua, Oscar

“…Purpose Here we show how a model-based approach may be used to provide further insight into the role of clinical and demographic covariates on the progression…”
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Mathematical Biology Models of Parkinson's Disease by Bakshi, Suruchi, Chelliah, Vijayalakshmi, Chen, Chao, Graaf, Piet H.

“…Parkinsons disease (PD) is a progressive neurodegenerative disease with substantial and growing socio‐economic burden. In this multifactorial disease, aging,…”
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Mathematical modelling of Centrosomin incorporation in Drosophila centrosomes by Bakshi, Suruchi D

“…Centrosomin (Cnn) is an integral centrosomal protein in Drosophila with orthologues in several species, including humans. The human orthologue of Cnn is…”
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