Search Results - "Baksh, Michael M."

Inhibitor of MYC identified in a Kröhnke pyridine library by Hart, Jonathan R., Garner, Amanda L., Yu, Jing, Ito, Yoshihiro, Sun, Minghao, Ueno, Lynn, Rhee, Jin-Kyu, Baksh, Michael M., Stefan, Eduard, Hartl, Markus, Bister, Klaus, Vogt, Peter K., Janda, Kim D.

“…In a fluorescence polarization screen for the MYC–MAX interaction, we have identified a novel small-molecule inhibitor of MYC, KJ-Pyr-9, from a Kröhnke…”
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Supported Lipid Bilayers on Fluorescent Nanodiamonds: A Structurally Defined and Versatile Coating for Bioapplications by Vavra, Jan, Rehor, Ivan, Rendler, Torsten, Jani, Mona, Bednar, Jan, Baksh, Michael M., Zappe, Andrea, Wrachtrup, Joerg, Cigler, Petr

“…Fluorescent nanodiamonds with nitrogen‐vacancy (NV) centers respond to local changes in electric and magnetic fields. These responses can be read optically as…”
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Detection of molecular interactions at membrane surfaces through colloid phase transitions by Groves, Jay T, Baksh, Michael M, Jaros, Michal

“…The molecular architecture of-and biochemical processes within-cell membranes play important roles in all living organisms, with many drugs and infectious…”
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Small Molecule Regulation of Protein Conformation by Binding in the Flap of HIV Protease by Tiefenbrunn, Theresa, Forli, Stefano, Baksh, Michael M, Chang, Max W, Happer, Meaghan, Lin, Ying-Chuan, Perryman, Alexander L, Rhee, Jin-Kyu, Torbett, Bruce E, Olson, Arthur J, Elder, John H, Finn, M. G, Stout, C. David

“…The fragment indole-6-carboxylic acid (1F1), previously identified as a flap site binder in a fragment-based screen against HIV protease (PR), has been…”
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Multivalent Targeting of the Asialoglycoprotein Receptor by Virus‐Like Particles by Hincapie, Robert, Bhattacharya, Sonia, Baksh, Michael M., Sanhueza, Carlos A., Echeverri, Elisa Schrader, Kim, Hyejin, Paunovska, Kalina, Podilapu, Ananda R., Xu, Minghao, Dahlman, James E., Finn, M. G.

“…The asialoglycoprotein receptor (ASGPR) is expressed in high density on hepatocytes. Multivalent variants of galactosyl carbohydrates bind ASGPR with high…”
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Efficient Liver Targeting by Polyvalent Display of a Compact Ligand for the Asialoglycoprotein Receptor by Sanhueza, Carlos A, Baksh, Michael M, Thuma, Benjamin, Roy, Marc D, Dutta, Sanjay, Préville, Cathy, Chrunyk, Boris A, Beaumont, Kevin, Dullea, Robert, Ammirati, Mark, Liu, Shenping, Gebhard, David, Finley, James E, Salatto, Christopher T, King-Ahmad, Amanda, Stock, Ingrid, Atkinson, Karen, Reidich, Benjamin, Lin, Wen, Kumar, Rajesh, Tu, Meihua, Menhaji-Klotz, Elnaz, Price, David A, Liras, Spiros, Finn, M. G, Mascitti, Vincent

“…A compact and stable bicyclic bridged ketal was developed as a ligand for the asialoglycoprotein receptor (ASGPR). This compound showed excellent ligand…”
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Learning from nature – Novel synthetic biology approaches for biomaterial design by Bryksin, Anton V., Brown, Ashley C., Baksh, Michael M., Finn, M.G., Barker, Thomas H.

“…[Display omitted] Many biomaterials constructed today are complex chemical structures that incorporate biologically active components derived from nature, but…”
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Membrane Association Dictates Ligand Specificity for the Innate Immune Receptor NOD2 by Schaefer, Amy K, Melnyk, James E, Baksh, Michael M, Lazor, Klare M, Finn, M. G, Grimes, Catherine Leimkuhler

“…The human gut must regulate its immune response to resident and pathogenic bacteria, numbering in the trillions. The peptidoglycan component of the bacterial…”
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Label-free quantification of membrane-ligand interactions using backscattering interferometry by Bornhop, Darryl J, Kussrow, Amanda K, Baksh, Michael M, Mileni, Mauro, Finn, M G

“…Although membrane proteins are ubiquitous within all living organisms and represent the majority of drug targets, a general method for direct, label-free…”
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An experimental check of backscattering interferometry by Baksh, Michael M., Finn, M.G.

“…•A recent paper (10.1016/j.snb.2015.06.121) incorrectly dismisses backscattering interferometry.•Potential reasons for this error are identified, including the…”
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Trimerization of the HIV Transmembrane Domain in Lipid Bilayers Modulates Broadly Neutralizing Antibody Binding by Reichart, Timothy M., Baksh, Michael M., Rhee, Jin-Kyu, Fiedler, Jason D., Sligar, Stephen G., Finn, M. G., Zwick, Michael B., Dawson, Philip E.

“…The membrane‐proximal external region (MPER) of HIV gp41 is an established target of antibodies that neutralize a broad range of HIV isolates. To evaluate the…”
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Heparin Binding to an Engineered Virus-like Nanoparticle Antagonist by Cheong, Ho Yong, Groner, Myles, Hong, Kevin, Lynch, Brennen, Hollingsworth, William R, Polonskaya, Zinaida, Rhee, Jin-Kyu, Baksh, Michael M, Finn, M. G, Gale, Andrew J, Udit, Andrew K

“…The anticoagulant activity of heparin administered during medical interventions must be reversed to restore normal clotting, typically by titrating with…”
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Direct Measurement of Trafficking of the Cystic Fibrosis Transmembrane Conductance Regulator to the Cell Surface and Binding to a Chemical Chaperone by Zhang, Zhihui, Baksh, Michael M, Finn, M. G, Heidary, David K, Richards, Christopher I

“…Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) result in the disease cystic fibrosis. Deletion of Phe508, the most prevalent…”
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Evolution and Protein Packaging of Small-Molecule RNA Aptamers by Lau, Jolene L, Baksh, Michael M, Fiedler, Jason D, Brown, Steven D, Kussrow, Amanda, Bornhop, Darryl J, Ordoukhanian, Phillip, Finn, M. G

“…A high-affinity RNA aptamer (K d = 50 nM) was efficiently identified by SELEX against a heteroaryldihydropyrimidine structure, chosen as a representative…”
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Universal Sensing by Transduction of Antibody Binding with Backscattering Interferometry by Kussrow, Amanda, Baksh, Michael M, Bornhop, Darryl J, Finn, M.G

“…All binding events induce a change in refractive index, and antibody–antigen interactions are no exception. We describe the use of backscattering…”
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Neuronal Activation by GPI-Linked Neuroligin-1 Displayed in Synthetic Lipid Bilayer Membranes by Baksh, Michael M, Dean, Camin, Pautot, Sophie, DeMaria, Shannon, Isacoff, Ehud, Groves, Jay T

“…We have characterized, in vitro, interactions between hippocampal neuronal cells and silica microbeads coated with synthetic, fluid, lipid bilayer membranes…”
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Electrostatically Targeted Intermembrane Lipid Exchange with Micropatterned Supported Membranes by Sapuri, Annapoorna R, Baksh, Michael M, Groves, Jay T

“…Herein we introduce a technique for selectively delivering membrane components to membrane patterns on a solid support. Electrostatic charge on membrane…”
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Trimerization of the HIV Transmembrane Domain in Lipid Bilayers Modulates Broadly Neutralizing Antibody Binding by Reichart, Timothy M., Baksh, Michael M., Rhee, Jin-Kyu, Fiedler, Jason D., Sligar, Stephen G., Finn, M. G., Zwick, Michael B., Dawson, Philip E.

“…The membrane‐proximal external region (MPER) of HIV gp41 is an established target of antibodies that neutralize a broad range of HIV isolates. To evaluate the…”
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Long‐Term Imaging: Supported Lipid Bilayers on Fluorescent Nanodiamonds: A Structurally Defined and Versatile Coating for Bioapplications (Adv. Funct. Mater. 45/2018) by Vavra, Jan, Rehor, Ivan, Rendler, Torsten, Jani, Mona, Bednar, Jan, Baksh, Michael M., Zappe, Andrea, Wrachtrup, Joerg, Cigler, Petr

“…Fluorescent nanodiamonds (FNDs) with nitrogen‐vacancy centers enable optical readout of local changes in electric and magnetic fields. In article 1803406, Petr…”
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Label-Free Molecular Observations of Membrane-Associated Species using Backscattering Interferometry by Baksh, Michael M., Lockwood, Ashley, Richards, Christopher, Finn, M.G., Heidary, David

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