Search Results - "Bakr, Rania"

Design, synthesis and biological evaluation of some novel benzothiazole/benzoxazole and/or benzimidazole derivatives incorporating a pyrazole scaffold as antiproliferative agents by Abdelgawad, Mohamed A., Bakr, Rania B., Omar, Hany A.

“…[Display omitted] •A series of substituted pyrazoles10a-c, 11a-c and 12a- was designed and prepared.•All the candidates…”
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Pyrimidine and fused pyrimidine derivatives as promising protein kinase inhibitors for cancer treatment by Abdellatif, Khaled R. A., Bakr, Rania B.

“…Pyrimidine ring and its fused derivatives including pyrazolo[3,4- d ]pyrimidine, pyrido[2,3- d ]pyrimidine, quinazoline, and furo[2,3- d ]pyrimidine compounds…”
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Synthesis of Chalcones Derivatives and Their Biological Activities: A Review by Elkanzi, Nadia A. A., Hrichi, Hajer, Alolayan, Ruba A., Derafa, Wassila, Zahou, Fatin M., Bakr, Rania B.

“…Chalcone derivatives are considered valuable species because they possess a ketoethylenic moiety, CO–CHCH–. Due to the presence of a reactive α,β-unsaturated…”
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Facile One-Pot Multicomponent Synthesis of Pyrazolo-Thiazole Substituted Pyridines with Potential Anti-Proliferative Activity: Synthesis, In Vitro and In Silico Studies by El Azab, Islam H., Bakr, Rania B., Elkanzi, Nadia A. A.

“…Pyrazolothiazole-substituted pyridine conjugates are an important class of heterocyclic compounds with an extensive variety of potential applications in the…”
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New 1,2,3-Triazole-Containing Hybrids as Antitumor Candidates: Design, Click Reaction Synthesis, DFT Calculations, and Molecular Docking Study by El Azab, Islam H, El-Sheshtawy, Hamdy S, Bakr, Rania B, Elkanzi, Nadia A A

“…In an effort to improve and achieve biologically active anticancer agents, a novel series of 1,2,3-triazole-containing hybrids were designed and efficiently…”
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Novel pyrimidine-pyridine hybrids: Synthesis, cyclooxygenase inhibition, anti-inflammatory activity and ulcerogenic liability by Abdelgawad, Mohamed A., Bakr, Rania B., Azouz, Amany A.

“…[Display omitted] •Compound 11c was the most active with edema inhibitory percent = 74% after 1 h.•The target compounds were detected to be selective…”
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New advances in synthesis and clinical aspects of pyrazolo[3,4-d]pyrimidine scaffolds by Abdellatif, Khaled R.A., Bakr, Rania B.

“…Pyrazolo[3,4-d]pyrimidine ring system constitute an important class of heterocyclic compounds which can serve as a promising scaffold exhibiting many…”
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Design, Synthesis, Docking Study of Pyrazolohydrazinopyrimidin‐4‐one Derivatives and Their Application as Antimicrobials by Alolayan, Ruba A., Ali Ahmed Elkanzi, Nadia, Hrichi, Hajer, Bakr, Rania B.

“…New series of pyrazoles 4a–c and pyrazolopyrimidines 5a–f had been constructed. The newly synthesized compounds were assessed for their antimicrobial activity…”
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Nitric Oxide-NASIDS Donor Prodrugs as Hybrid Safe Anti-inflammatory Agents by Abdellatif, Khaled R A, Abdelall, Eman K A, Bakr, Rania B

“…Selective inhibition of cyclooxygenase-2 (COX-2) isozyme afforded a useful drug design concept that resulted in the development of effective anti-inflammatory…”
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Preparation of some novel thiazolidinones, imidazolinones, and azetidinone bearing pyridine and pyrimidine moieties with antimicrobial activity by Bakr, Rania B., Elkanzi, Nadia A. A.

“…By aiming to design new antimicrobial agents, we prepared new series of thiazolidin‐4‐ones(12a–d), imidazolin‐4‐ones(13a–d), and azetidin‐2‐ones (14a–d),…”
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Selective cyclooxygenase inhibition and ulcerogenic liability of some newly prepared anti-inflammatory agents having thiazolo[4,5-d]pyrimidine scaffold by Bakr, Rania B., Ghoneim, Amira A., Azouz, Amany A.

“…New thiazolo[4,5-d]pyrimidines (9a-l) were prepared and screened for their cyclooxygenase inhibitory effect, anti-inflammatory activity and ulcerogenic…”
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New pyrimidine-benzoxazole/benzimidazole hybrids: Synthesis, antioxidant, cytotoxic activity, in vitro cyclooxygenase and phospholipase A2-V inhibition by Abdelgawad, Mohamed A., Bakr, Rania B., Ahmad, Waqas, Al-Sanea, Mohammad M., Elshemy, Heba A.H.

“…[Display omitted] •The new intermediates new 6a&b and the target new pyrimidines 7a&b were designed and prepared.•The structure of new targets was proved using…”
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Synthesis, EGFR Inhibition and Anti-cancer Activity of New 3,6-dimethyl-1-phenyl-4-(substituted-methoxy)pyrazolo[3,4-d] pyrimidine Derivatives by Bakr, Rania B, Mehany, Ahmed B M, Abdellatif, Khaled R A

“…as EGFR inhibitors, mammalian target of rapamycin (mTOR) inhibitors, Src or dual Src/Abl inhibitors, glycogen synthase kinase-3b (GSK-3b) inhibitors or cyclin…”
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Construction and Docking Studies of Novel Pyrimido[4,5‐b]quinolines as Antimicrobial Agents by Bakr, Rania B., El Azab, Islam H., Elkanzi, Nadia A. A.

“…In order to develop novel antimicrobial agents, we prepared quinoline bearing pyrimidine analogues 2–7, 8 a–d and 9 a–d and their structures were elucidated by…”
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Review of the recent advances of pyrazole derivatives as selective COX-2 inhibitors for treating inflammation by Ghoneim, Mohammed M, Abdelgawad, Mohamed A, Elkanzi, Nadia A A, Bakr, Rania B

“…Pyrazole heterocycle is regarded as an extremely significant agent for the therapy of inflammation. Celecoxib, lonazolac, deracoxib, and phenylbutazone are…”
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Antioxidant and Antimicrobial Potential of 1,8‐Naphthyridine Based Scaffolds: Design, Synthesis and in Silico Simulation Studies within Topoisomerase II by Elkanzi, Nadia A. A., Hrichi, Hajer, Muqbil Alsirhani, Alaa, Bakr, Rania B.

“…A series of spiro β‐Lactams (4 a–c, 7 a–c) and thiazolidinones (5 a–c, 8 a–c) possessing 1,8‐naphthyridine moiety were synthesized in this study. The structure…”
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Design, Synthesis, Molecular Docking of Novel Substituted Pyrimidinone Derivatives as Anticancer Agents by Ghoneim, Amira Atef, El-Farargy, Ahmed Foud, Bakr, Rania B.

“…Novel derivatives of pyrimidinone ring carrying some five-membered heterocycles had been designed and prepared. 1,3-Thiazolidin-4-one derivative 7 was prepared…”
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Synthesis and anticancer activity of some new pyrazolo[3,4-d]pyrimidin-4-one derivatives by Abdellatif, Khaled R A, Abdelall, Eman K A, Abdelgawad, Mohamed A, Ahmed, Rasha R, Bakr, Rania B

“…3,6-Dimethyl-1-phenyl-1H-pyrazolo[3,4-d][1,3]oxazin-4-one (3) was prepared by hydrolysis of ethyl 5-amino-3-methyl-1-phenyl-1H-pyrazole-4-carboxylate (1) to…”
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A literature review on pharmacological aspects, docking studies, and synthetic approaches of quinazoline and quinazolinone derivatives by Ghoneim, Mohammed M., Abdelgawad, Mohamed A., Elkanzi, Nadia A. A., Parambi, Della Grace Thomas, Alsalahat, Izzeddin, Farouk, Amr, Bakr, Rania B.

“…Quinazoline and quinazolinone derivatives piqued medicinal chemistry interest in developing novel drug candidates owing to their pharmacological potential…”
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Design and Synthesis of Pyridine and Thiazole Derivatives as Eco‐friendly Insecticidal to Control Olive Pests by Elkanzi, Nadia A. A., Al‐Hazmi, Aryam Khaled Ghayad, Bakr, Rania B., Gad, Mohamed A., Abd El‐Lateef, Hany M., Ali, Ali M.

“…Treatment of p‐tosyloxybenzaldehyde (1) with ethyl cyanoacetate afforded ethyl 2‐cyano‐3‐(4‐{[(4‐methylphenyl)sulfonyl]oxy}phenyl)acrylate (2) which reacted…”
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