The Multi-Partner Consortium to Expand Dementia Research in Latin America (ReDLat): Driving Multicentric Research and Implementation Science

Dementia is becoming increasingly prevalent in Latin America, contrasting with stable or declining rates in North America and Europe. This scenario places unprecedented clinical, social, and economic burden upon patients, families, and health systems. The challenges prove particularly pressing for c...

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Published in:	Frontiers in neurology Vol. 12; p. 631722
Main Authors:	Ibanez, Agustin, Yokoyama, Jennifer S, Possin, Katherine L, Matallana, Diana, Lopera, Francisco, Nitrini, Ricardo, Takada, Leonel T, Custodio, Nilton, Sosa Ortiz, Ana Luisa, Avila-Funes, José Alberto, Behrens, Maria Isabel, Slachevsky, Andrea, Myers, Richard M, Cochran, J Nicholas, Brusco, Luis Ignacio, Bruno, Martin A, Brucki, Sonia M D, Pina-Escudero, Stefanie Danielle, Okada de Oliveira, Maira, Donnelly Kehoe, Patricio, Garcia, Adolfo M, Cardona, Juan Felipe, Santamaria-Garcia, Hernando, Moguilner, Sebastian, Duran-Aniotz, Claudia, Tagliazucchi, Enzo, Maito, Marcelo, Longoria Ibarrola, Erika Mariana, Pintado-Caipa, Maritza, Godoy, Maria Eugenia, Bakman, Vera, Javandel, Shireen, Kosik, Kenneth S, Valcour, Victor, Miller, Bruce L
Format:	Journal Article
Language:	English
Published:	Switzerland Frontiers Media 11-03-2021 Frontiers Media S.A
Subjects:	Alzheimer's disease dementia fronto-temporal dementia genetics Life Sciences Neurology Santé publique et épidémiologie SDOH SES SES genetics fronto-temporal dementia dementia SDOH Alzheimer's disease Latin America implementation science Implementation science Fronto-temporal dementia Genetics Dementia
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Summary:	Dementia is becoming increasingly prevalent in Latin America, contrasting with stable or declining rates in North America and Europe. This scenario places unprecedented clinical, social, and economic burden upon patients, families, and health systems. The challenges prove particularly pressing for conditions with highly specific diagnostic and management demands, such as frontotemporal dementia. Here we introduce a research and networking initiative designed to tackle these ensuing hurdles, the Multi-partner consortium to expand dementia research in Latin America (ReDLat). First, we present ReDLat's regional research framework, aimed at identifying the unique genetic, social, and economic factors driving the presentation of frontotemporal dementia and Alzheimer's disease in Latin America relative to the US. We describe ongoing ReDLat studies in various fields and ongoing research extensions. Then, we introduce actions coordinated by ReDLat and the Latin America and Caribbean Consortium on Dementia (LAC-CD) to develop culturally appropriate diagnostic tools, regional visibility and capacity building, diplomatic coordination in local priority areas, and a knowledge-to-action framework toward a regional action plan. Together, these research and networking initiatives will help to establish strong cross-national bonds, support the implementation of regional dementia plans, enhance health systems' infrastructure, and increase translational research collaborations across the continent.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 Reviewed by: Giancarlo Logroscino, University of Bari Aldo Moro, Italy; Barbara Borroni, University of Brescia, Italy; Filipe Brogueira Rodrigues, Universidade de Lisboa, Portugal Edited by: Rosanna Tortelli, University College London, United Kingdom This article was submitted to Dementia and Neurodegenerative Diseases, a section of the journal Frontiers in Neurology
ISSN:	1664-2295 1664-2295
DOI:	10.3389/fneur.2021.631722