Search Results - "Bakker, G H"

Treatment of breast cancer with different antiprogestins: preclinical and clinical studies by Bakker, G H, Setyono-Han, B, Portengen, H, De Jong, F H, Foekens, J A, Klijn, J G

“…Treatment with antiprogestins is a new treatment modality for breast cancer. Previously, in rats with DMBA-induced mammary tumors we observed significant…”
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Effects of the progesterone antagonist RU486 on ovarian activity in the rat by van der Schoot, P, Bakker, G H, Klijn, J G

“…Adult female rats were treated for 2 or 4 weeks with the progesterone antagonist RU486 to study its effect on the regulation of ovarian function. In rats with…”
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Antiprogestins, a new form of endocrine therapy for human breast cancer by KLIJN, J. G. M, DE JONG, F. H, BAKKER, G. H, LAMBERTS, S. W. J, RODENBURG, C. J, ALEXIEVA-FIGUSCH, J

“…The antitumor, endocrine, hematological, biochemical, and side effects of chronic second-line treatment with the antiprogestin mifepristone (RU) 486) were…”
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Growth factor-receptor pathway interfering treatment by somatostatin analogs and suramin: preclinical and clinical studies by Klijn, J G, Setyono-Han, B, Bakker, G H, van der Burg, M E, Bontenbal, M, Peters, H A, Sieuwerts, A M, Berns, P M, Foekens, J A

“…Interference in growth factor mediated pathways is a new strategy in the treatment of cancer. Somatostatin analogs can inhibit hormone and growth factor…”
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Endocrine and antitumor effects of combined treatment with an antiprogestin and antiestrogen or luteinizing hormone-releasing hormone agonist in female rats bearing mammary tumors by Bakker, G H, Setyono-Han, B, Portengen, H, De Jong, F H, Foekens, J A, Klijn, J G

“…Rats bearing mammary tumors induced with dimethylbenzanthracene were treated with the antiprogestin mifepristone (RU486; 10 mg/kg.day, sc), the antiestrogen…”
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Effects of castration, alone and in combination with aminoglutethimide, on growth of (pre)neoplastic lesions in exocrine pancreas of rats and hamsters by Meijers, M, Woutersen, R A, van Garderen-Hoetmer, A, Bakker, G H, de Jong, F H, Foekens, J A, Klijn, J G

“…We studied the effects of hormonal manipulation by orchiectomy, alone or in combination with the aromatase inhibitor aminoglutethimide (AGT), and by…”
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The somatostatin analog Sandostatin (SMS201-995) in treatment of DMBA-induced rat mammary tumors by BAKKER, G. H, SETYONO-HAN, B, FOEKENS, J. A, PORTENGEN, H, VAN PUTTEN, W. L. J, DE JONG, F. H, LAMBERTS, S. W. J, REUBI, J. C, KLIJN, J. G. M

“…The effects of treatment with a somatostatin analog (Sandostatin, SMS201-995) were investigated in female rats with dimethylbenzanthracene (DMBA)-induced rat…”
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Effects of sandostatin and castration on pancreatic carcinogenesis in rats and hamsters by Meijers, M, Woutersen, R A, van Garderen-Hoetmer, A, Bakker, G H, de Jong, F H, Foekens, J A, Klijn, J G

“…The effects of treatment with the somatostatin analogue Sandostatin, separately and in combination with surgical castration, on the development of…”
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Lutropin-dependent protein phosphorylation and steroidogenesis in rat tumour Leydig cells by Bakker, G H, Hoogerbrugge, J W, Rommerts, F F, van der Molen, H J

“…Tumour Leydig cells have been incubated in the presence or absence of lutropin (luteinizing hormone, ;LH'). Stimulation of cells with lutropin (1000ng/ml) in…”
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The role of phosphoproteins and newly synthesized proteins in the hormonal regulation of steroidogenesis in Leydig cells by Rommerts, F F, Bakker, G H, van der Molen, H J

“…LH activation of steroidogenesis in Leydig cells is accompanied by increased phosphorylation of at least 5 phosphoproteins. The 17000 Da protein is localized…”
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Lutropin increases phosphorylation of a 33 000-dalton ribosomal protein in rat tumour Leydig cells by Bakker, G H, Hoogerbrugge, J W, Rommerts, F F, van der Molen, H J

“…Addition of lutropin (luteinizing hormone, 'LH') and 3-isobutyl-1-methylxanthine to tumour Leydig cells stimulated phosphorylation of five proteins, of 17 000,…”
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LH-dependent steroid production and protein phosphorylation in culture of rat tumour Leydig cells by Bakker, G H, Hoogerbrugge, W, Rommerts, F F, van der Molen, H J

“…The possible cause of the decreased responsiveness of cultured Leydig cells to stimulation with LH was investigated with rat tumour Leydig cells cultured at 32…”
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Comparison of the actions of the antiprogestin mifepristone (RU486), the progestin megestrol acetate, the LHRH analog buserelin, and ovariectomy in treatment of rat mammary tumors by Bakker, G H, Setyono-Han, B, Henkelman, M S, de Jong, F H, Lamberts, S W, van der Schoot, P, Klijn, J G

“…The effects of the synthetic antiprogestin mifepristone (RU486) on growth of dimethylbenzanthracene (DMBA)-induced mammary tumors in female rats were…”
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Rationale for suppression of adrenal steroidogenesis in advanced prostatic cancer by Blankenstein, M A, Bakker, G H

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Subcellular localization of LH-dependent phosphoproteins and their possible role in regulation of steroidogenesis in rat tumour Leydig cells by Bakker, Ger H., Hoogerbrugge, Jos W., Rommerts, Focko F.G., van der Molen, Henk J.

“…Stimulation of rat tumour Leydig cells with LH resulted in phosphorylation of 7 proteins of 17, 22, 24, 33, 43, 57 and 76 kDa, and in dephosphorylation of a…”
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Actions of luteinizing hormone on protein phosphorylation and steroidogenesis in tumor Leydig cells by Bakker, G H, Rommerts, F F, van der Molen, H J

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Lutropin stimulates de novo synthesis of short-lived proteins required for lutropin-dependent steroid production in tumour Leydig cells by Bakker, G H, Hoogerbrugge, J W, Rommerts, F F, van der Molen, H J

“…Continuous protein synthesis is required for the hormonal regulation of cholesterol side chain cleavage activity. A protein with a short half-life (t1/2 = 2-13…”
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Promoting quality through surveillance of surgical site infections: Five prevention success stories by Geubbels, Eveline L.P.E., Bakker, Hannie G., Houtman, Patricia, van Noort-Klaassen, Marika A., Pelk, Marianne S.J., Sassen, Ton M., Wille, Jan C.

“…Public reports of successful quality improvement efforts are useful, but seldom available. We present 5 successful efforts to prevent surgical site infections…”
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Subcellular localization of LH-dependent phosphoproteines and their possible role in regulation of steroidogenesis in rat tumour Leydig cells by BAKKER, G. H, HOOGERBRUGGE, J. W, ROMMERTS, F.F.G, VAN DER MOLEN, H. J

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An enzyme-linked immunosorbent assay (ELISA) for monitoring rodent colonies for Streptobacillus moniliformis antibodies by Boot, R, Bakker, R H, Thuis, H, Veenema, J L, De Hoog, H

“…An enzyme-linked immunosorbent assay (ELISA) to measure Streptobacillus moniliformis antibodies in mice and rats was developed. Twelve S. moniliformis strains…”
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