Search Results - "Bakker, A.M."

Characterization and standardization of Sabin based inactivated polio vaccine: Proposal for a new antigen unit for inactivated polio vaccines by Westdijk, Janny, Brugmans, Debbie, Martin, Javier, Oever, Aart van’t, Bakker, Wilfried A.M, Levels, Lonneke, Kersten, Gideon

“…Abstract GMP-batches of Sabin-IPV were characterized for their antigenic and immunogenic properties. Antigenic fingerprints of Sabin-IPV reveal that the…”
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Reactogenicity and immunogenicity of inactivated poliovirus vaccine produced from Sabin strains: A phase I Trial in healthy adults in Cuba by Resik, Sonia, Tejeda, Alina, Fonseca, Magilé, Alemañi, Nilda, Diaz, Manuel, Martinez, Yenisleidys, Garcia, Gloria, Okayasu, Hiromasa, Burton, Anthony, Bakker, Wilfried A.M, Verdijk, Pauline, Sutter, Roland W

“…Abstract Background To ensure that developing countries have the option to produce inactivated poliovirus vaccine (IPV), the Global Polio Eradication…”
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Inactivated polio vaccine development for technology transfer using attenuated Sabin poliovirus strains to shift from Salk-IPV to Sabin-IPV by Bakker, Wilfried A.M, Thomassen, Yvonne E, van’t Oever, Aart G, Westdijk, Janny, van Oijen, Monique G.C.T, Sundermann, Lars C, van’t Veld, Peter, Sleeman, Eelco, van Nimwegen, Fred W, Hamidi, Ahd, Kersten, Gideon F.A, van den Heuvel, Nico, Hendriks, Jan T, van der Pol, Leo A

“…Abstract Industrial-scale inactivated polio vaccine (IPV) production dates back to the 1960s when at the Rijks Instituut voor de Volksgezondheid (RIV) in…”
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Development of inactivated poliovirus vaccine from Sabin strains: A progress report by Okayasu, Hiromasa, Sein, Carolyn, Hamidi, Ahd, Bakker, Wilfried A.M., Sutter, Roland W.

“…The Global Polio Eradication Initiative (GPEI) has seen significant progress since it began in 1988, largely due to the worldwide use of oral poliovirus…”
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Expression of Ep-CAM shifts the state of cadherin-mediated adhesions from strong to weak by Winter, Manon J, Nagelkerken, Bas, Mertens, Alexander E.E, Rees-Bakker, Hellen A.M, Briaire-de Bruijn, Inge H, Litvinov, Sergey V

“…Various adhesion molecules play an important role in defining cell fate and maintaining tissue integrity. Therefore, cross-signaling between adhesion receptors…”
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Development of an animal component free production process for Sabin inactivated polio vaccine by Suarez-Zuluaga, Diego A., van der Pol, Leo A., van 't Oever, Aart G., Bakker, Wilfried A.M., Thomassen, Yvonne E.

“…Inactivated polio vaccine production using attenuated Sabin strains (sIPV) instead of wild type polio viruses (cIPV) is an initiative encouraged by the World…”
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Kinetic model for adherent Vero cell growth and poliovirus production in batch bioreactors by Jiang, Yang, van der Welle, Joyce E., Rubingh, Olaf, van Eikenhorst, Gerco, Bakker, Wilfried A.M., Thomassen, Yvonne E.

“…[Display omitted] •Mathematical model for Vero cell growth in batch bioreactors.•Mathematical model for poliovirus proliferation on Vero cells.•Oxygen uptake…”
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sIPV process development for costs reduction by Thomassen, Yvonne E, Bakker, Wilfried A.M

“…Abstract Polio is expected to be eradicated within only a few years from now. Upon polio eradication, the use of oral polio vaccines, which can cause…”
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Safety and immunogenicity of a primary series of Sabin-IPV with and without aluminum hydroxide in infants by Verdijk, Pauline, Rots, Nynke Y, van Oijen, Monique G.C.T, Weldon, William C, Oberste, M. Steven, Okayasu, Hiromasa, Sutter, Roland W, Bakker, Wilfried A.M

“…Abstract Background An inactivated poliovirus vaccine (IPV) based on attenuated poliovirus strains (Sabin-1, -2 and -3) was developed for technology transfer…”
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Epithelial Cell Adhesion Molecule (Ep-CAM) Modulates Cell-Cell Interactions Mediated by Classic Cadherins by Litvinov, Sergey V., Balzar, Maarten, Winter, Manon J., Hellen A. M. Bakker, Briaire-de Bruijn, Inge H., Prins, Frans, Fleuren, Gert Jan, Warnaar, Sven O.

“…The contribution of noncadherin-type, Ca2+-independent cell-cell adhesion molecules to the organization of epithelial tissues is, as yet, unclear. A…”
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Antigen sparing with adjuvanted inactivated polio vaccine based on Sabin strains by Westdijk, Janny, Koedam, Patrick, Barro, Mario, Steil, Benjamin P, Collin, Nicolas, Vedvick, Thomas S, Bakker, Wilfried A.M, van der Ley, Peter, Kersten, Gideon

“…Highlights ► Six adjuvants with Sabin inactivated poliovirus vaccine were evaluated in rats. ► The increase of neutralizing antibodies was 3-, 15-, 24-fold for…”
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Improved poliovirus d -antigen yields by application of different Vero cell cultivation methods by Thomassen, Yvonne E, Rubingh, Olaf, Wijffels, René H, van der Pol, Leo A, Bakker, Wilfried A.M

“…Highlights • Vero cells were grown in batch, semi-batch, perfusion and recirculation strategies. • At high cell densities (to 5 × 106 cells mL−1 ) cells were…”
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PER.C6® cells as a serum-free suspension cell platform for the production of high titer poliovirus: A potential low cost of goods option for world supply of inactivated poliovirus vaccine by Sanders, Barbara P, Edo-Matas, Diana, Custers, Jerome H.H.V, Koldijk, Martin H, Klaren, Vincent, Turk, Marije, Luitjens, Alfred, Bakker, Wilfried A.M, Uytdehaag, Fons, Goudsmit, Jaap, Lewis, John A, Schuitemaker, Hanneke

“…Highlights ► A novel cell platform is proposed for poliovirus and consequently IPV production. ► The cell-line is susceptible to all three polio virus…”
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Assessment of mass transfer and mixing in rigid lab-scale disposable bioreactors at low power input levels by van Eikenhorst, Gerco, Thomassen, Yvonne E., van der Pol, Leo A., Bakker, Wilfried A. M.

“…Mass transfer, mixing times and power consumption were measured in rigid disposable stirred tank bioreactors and compared to those of a traditional glass…”
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Scale-down of the inactivated polio vaccine production process by Thomassen, Yvonne E., van 't Oever, Aart G., Vinke, Marian, Spiekstra, Arjen, Wijffels, René H., van der Pol, Leo A., Bakker, Wilfried A.M.

“…The anticipated increase in the demand for inactivated polio vaccines resulting from the success in the polio eradication program requires an increase in…”
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Safety and immunogenicity of inactivated poliovirus vaccine based on Sabin strains with and without aluminum hydroxide: A phase I trial in healthy adults by Verdijk, Pauline, Rots, Nynke Y, van Oijen, Monique G.C.T, Oberste, M. Steven, Boog, Claire J, Okayasu, Hiromasa, Sutter, Roland W, Bakker, Wilfried A.M

“…Highlights • Both Sabin-IPV and Sabin-IPV adjuvanted with aluminum hydroxide are well-tolerated. • A booster with Sabin-IPV or adjuvanted Sabin-IPV is equally…”
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A mucosal adjuvant for the inactivated poliovirus vaccine by Steil, Benjamin P, Jorquera, Patricia, Westdijk, Janny, Bakker, Wilfried A.M, Johnston, Robert E, Barro, Mario

“…Highlights • GVI 3000 adjuvant increased the potency of IPV in mice. • Systemic and mucosal immune responses to IPV were increased in mice. • IPV + GVI3000…”
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Comparison of initial feasibility of host cell lines for viral vaccine production by Vlecken, Danielle H.W., Pelgrim, Ralf P.M., Ruminski, Slawomir, Bakker, Wilfried A.M., van der Pol, Leo A.

“…•Virus host cells compared.•Serum interference and viral replication.•HPV receptor expression. In order to reduce the time required for the development and…”
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Multivariate data analysis on historical IPV production data for better process understanding and future improvements by Thomassen, Yvonne E, van Sprang, Eric N.M, van der Pol, Leo A, Bakker, Wilfried A.M

“…Historical manufacturing data can potentially harbor a wealth of information for process optimization and enhancement of efficiency and robustness. To extract…”
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Mathematical model of adherent Vero cell growth and poliovirus production in animal component free medium by Ursache, Ramona V., Thomassen, Yvonne E., van Eikenhorst, Gerco, Verheijen, Peter J. T., Bakker, Wilfried A. M.

“…Sabin–IPV (or sIPV, inactivated polio vaccine based on attenuated Sabin strains) is anticipated to replace the oral polio vaccine for the endgame in polio…”
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