Search Results - "Bakhtiar, Ray"

Immunoaffinity Purification Using Anti-PEG Antibody Followed by Two-Dimensional Liquid Chromatography/Tandem Mass Spectrometry for the Quantification of a PEGylated Therapeutic Peptide in Human Plasma by Xu, Yang, Mehl, John T., Bakhtiar, Ray, Woolf, Eric J.

“…Quantification of a PEGylated peptide in human plasma using LC−MS/MS to support clinical studies presented challenges in terms of assay sensitivity,…”
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Application of miniaturized immunoassays to discovery pharmacokinetic bioanalysis by Roman, Jeanette, Qiu, Julia, Dornadula, Geethanjali, Hamuro, Lora, Bakhtiar, Ray, Verch, Thorsten

“…Pharmacokinetic properties of biotherapeutics are an important aspect of preclinical drug development. The lead identification and optimization space is…”
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Antibody drug conjugates by Bakhtiar, Ray

“…Antibody drug conjugates (ADCs) have emerged as a viable option in targeted delivery of highly potent cytotoxic drugs in treatment of solid tumors. At the time…”
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CYTOCHROME P450 3A4 IS THE MAJOR ENZYME INVOLVED IN THE METABOLISM OF THE SUBSTANCE P RECEPTOR ANTAGONIST APREPITANT by Sanchez, Rosa I, Wang, Regina W, Newton, Deborah J, Bakhtiar, Ray, Lu, Ping, Chiu, Shuet-Hing Lee, Evans, David C, Huskey, Su-Er W

“…The contribution of human cytochrome P450 (P450) isoforms to the metabolism of aprepitant in humans was investigated using recombinant P450s and inhibition…”
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Use of a quadrupole linear ion trap mass spectrometer in metabolite identification and bioanalysis by Xia, Yuan-Qing, Miller, Jeffrey D., Bakhtiar, Ray, Franklin, Ronald B., Liu, David Q.

“…A new type of quadrupole linear ion trap mass spectrometer, Q TRAP™ LC/MS/MS system (Q TRAP™), was evaluated for its performance in two studies: firstly, the…”
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Surface Plasmon Resonance Spectroscopy: A Versatile Technique in a Biochemist’s Toolbox by Bakhtiar, Ray

“…Surface plasmon resonance (SPR) spectroscopy is a powerful, label-free technique to monitor noncovalent molecular interactions in real time and in a…”
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Automated online dual-column extraction coupled with teicoplanin stationary phase for simultaneous determination of ( R)- and ( S)-propranolol in rat plasma using liquid chromatography–tandem mass spectrometry by Xia, Yuan-Qing, Bakhtiar, Ray, Franklin, Ronald B

“…An automated online sample extraction method for rat plasma was developed and validated for the quantification of ( R)- and ( S)-propranolol following the…”
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Therapeutic Recombinant Monoclonal Antibodies by Bakhtiar, Ray

“…During the last two decades, the rapid growth of biotechnology-derived techniques has led to a myriad of therapeutic recombinant monoclonal antibodies with…”
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Biomarkers in drug discovery and development by Bakhtiar, Ray

“…Biomarkers have shown promising utilities at various stages of the pharmaceutical R & D. With the recent technological advancements and the introduction of…”
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Identification of a new source of interference leached from polypropylene tubes in mass-selective analysis by Xia, Yuan-Qing, Patel, Shefali, Bakhtiar, Ray, Franklin, Ronald B., Doss, George A.

“…An interference leached from polypropylene tubes was identified to be a sulfoxide oxidative product of didodecyl 3,3′-thiodipropionate (DDTDP) that is used to…”
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Characterization of Cytochrome c Variants with High-Resolution FTICR Mass Spectrometry: Correlation of Fragmentation and Structure by Wu, Qinyuan, Van Orden, Steven, Cheng, Xueheng, Bakhtiar, Ray, Smith, Richard D

“…The dissociation of cytochrome c ions (15+ charge state) generated by electrospray ionization has been studied by Fourier transform ion cyclotron resonance…”
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Electrospray ionization and matrix-assisted laser desorption ionization mass spectrometry by Bakhtiar, Ray, Nelson, Randall W.

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Miniaturized immunoassays: moving beyond the microplate by Verch, Thorsten, Bakhtiar, Ray

“…After more than 40 years, immunoassays are still the backbone of protein biomarker analysis in clinical diagnostics and drug development. They have come a long…”
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Validation of an LC-MS/MS method for simultaneous quantification of venlafaxine and its five metabolites in rat plasma and its application in a pharmacokinetic study by Gu, Guodong, Black, Michelle, Cookson, Colt, Fiorella, Anna, Li, Yinghe, Gorman, Steven H., Bakhtiar, Ray

“…A sensitive, selective, and reliable LC-MS/MS method was developed and validated for simultaneous quantification of venlafaxine (VEN) and its 5 metabolites…”
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Electron capture dissociation mass spectrometry in characterization of peptides and proteins by BAKHTIAR, Ray, ZIQIANG GUAN

“…Electron capture dissociation (ECD) represents one of the most recent and significant advancements in tandem mass spectrometry (MS/MS) for the identification…”
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Development and Utility of an ELISA Method for Sensitive and Specific Detection of IgE Antidrug Antibodies by Zhong, Zhandong Don, Jiang, Lynn L., Khandelwal, Puneet, Clarke, Adam W., Bakhtiar, Ray, Zou, Linglong

“…Biologics can potentially induce unwanted immune responses, leading to formation of antidrug antibodies (ADA) of various affinity, isotypes, and subclasses…”
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BRAIN PENETRATION OF APREPITANT, A SUBSTANCE P RECEPTOR ANTAGONIST, IN FERRETS by HUSKEY, Su-Er W, DEAN, Brian J, HORA, Donald F, CHIU, Shuet-Hing L, BAKHTIAR, Ray, SANCHEZ, Rosa I, TATTERSALL, F. David, RYCROFT, Wayne, HARGREAVES, Richard, WATT, Alan P, CHICCHI, Gary G, KEOHANE, Carolann

“…The pharmacokinetics, metabolism, and brain penetration of the neurokinin 1 (NK 1 ) receptor antagonist (substance P receptor antagonist), aprepitant…”
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Correction to: Development and Utility of an ELISA Method for Sensitive and Specific Detection of IgE Antidrug Antibodies by Jiang, Lynn L., Khandelwal, Puneet, Clarke, Adam W., Bakhtiar, Ray, Zou, Linglong, Zhong, Zhandong Don

“…During the production process, the author order of Zhandong Don Zhong and Lynn L. Jiang were inadvertently placed. Lynn L. Jiang is the first author of this…”
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Sensitivity improvement of the LC–MS/MS quantification of carbidopa in human plasma and urine by derivatization with 2,4-pentanedione by van de Merbel, Nico C., Bronsema, Kees J., Gorman, Steven H., Bakhtiar, Ray

“…•A derivatization of carbidopa with 2,4-pentanedione allows LC–MS/MS quantification down to 1ng/mL in plasma and 100ng/mL in urine.•This represents at least a…”
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Liquid chromatographic–tandem mass spectrometry assay for the quantification of MDT‐637 in human nasal wash by Karnik, Shane C., Cook, Robert, Gorman, Steve H., Bakhtiar, Ray

“…MDT‐637 is a new chemical entity that shows potent and selective antiviral activity against respiratory syncytial virus. As part of the new drug development…”
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