Search Results - "Bakermans, Adrianus J."
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Dynamic MR imaging of cerebral perfusion during bicycling exercise
Published in NeuroImage (Orlando, Fla.) (15-04-2022)“…Habitual physical activity is beneficial for cerebrovascular health and cognitive function. Physical exercise therefore constitutes a clinically relevant…”
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Heart wall myofibers are arranged in minimal surfaces to optimize organ function
Published in Proceedings of the National Academy of Sciences - PNAS (12-06-2012)“…Heart wall myofibers wind as helices around the ventricles, strengthening them in a manner analogous to the reinforcement of concrete cylindrical columns by…”
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Trimetazidine in heart failure with preserved ejection fraction: a randomized controlled cross-over trial
Published in ESC Heart Failure (01-10-2023)“…Impaired myocardial energy homeostasis plays an import role in the pathophysiology of heart failure with preserved ejection fraction (HFpEF). Left ventricular…”
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A 72-channel receive array coil allows whole-heart cine MRI in two breath holds
Published in European radiology experimental (01-11-2022)“…Background A new 72-channel receive array coil and sensitivity encoding, compressed (C-SENSE) and noncompressed (SENSE), were investigated to decrease the…”
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Fasting-Induced Myocardial Lipid Accumulation in Long-Chain Acyl-CoA Dehydrogenase Knockout Mice Is Accompanied by Impaired Left Ventricular Function
Published in Circulation. Cardiovascular imaging (01-09-2011)“…Lipotoxicity may be a key contributor to the pathogenesis of cardiac abnormalities in mitochondrial long-chain fatty acid β-oxidation (FAO) disorders. Few data…”
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Marathon running transiently depletes the myocardial lipid pool
Published in Physiological reports (01-09-2020)“…Lipids, stored as intracellular triacylglycerol droplets within the myocardium, serve as an important source of energy, particularly in times of prolonged…”
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Human Cardiac 31P-MR Spectroscopy at 3 Tesla Cannot Detect Failing Myocardial Energy Homeostasis during Exercise
Published in Frontiers in physiology (27-11-2017)“…Phosphorus-31 magnetic resonance spectroscopy ( 31 P-MRS) is a unique non-invasive imaging modality for probing in vivo high-energy phosphate metabolism in the…”
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Exercise MR of Skeletal Muscles, the Heart, and the Brain
Published in Journal of magnetic resonance imaging (10-05-2024)“…Magnetic resonance (MR) imaging (MRI) is routinely used to evaluate organ morphology and pathology in the human body at rest or in combination with…”
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Quantitative MRI Reveals Microstructural Changes in the Upper Leg Muscles After Running a Marathon
Published in Journal of magnetic resonance imaging (01-08-2020)“…Background The majority of sports‐related injuries involve skeletal muscle. Unlike acute trauma, which is often caused by a single traumatic event leading to…”
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The hemodynamic cardiac profiler volume-time curves and related parameters: an MRI validation study
Published in Physiological measurement (10-01-2024)“…The hemodynamic cardiac profiler (HCP) is a new, non-invasive, operator-independent screening tool that uses six independent electrode pairs on the frontal…”
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Dynamic magnetic resonance measurements of calf muscle oxygenation and energy metabolism in peripheral artery disease
Published in Journal of magnetic resonance imaging (01-01-2020)“…Background Clinical assessments of peripheral artery disease (PAD) severity are insensitive to pathophysiological changes in muscle tissue oxygenation and…”
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A comparison of myocardial magnetic resonance extracellular volume mapping at 3 T against histology of tissue collagen in severe aortic valve stenosis and obstructive hypertrophic cardiomyopathy
Published in Magma (New York, N.Y.) (01-10-2023)“…Objective Quantitative extracellular volume fraction (ECV) mapping with MRI is commonly used to investigate in vivo diffuse myocardial fibrosis. This study…”
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Pre-Participation Screenings Frequently Miss Occult Cardiovascular Conditions in Apparently Healthy Male Middle-Aged First-Time Marathon Runners
Published in Cardiology (2024)“…The optimal pre-participation screening strategy to identify athletes at risk for exercise-induced cardiovascular events is unknown. We therefore aimed to…”
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Myocardial energy shortage and unmet anaplerotic needs in the fasted long-chain acyl-CoA dehydrogenase knockout mouse
Published in Cardiovascular research (01-12-2013)“…The aim of this animal study is to assess fasting-induced changes in myocardial substrate metabolism and energy status as a consequence of mitochondrial…”
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Quantification of Myocardial Creatine and Triglyceride Content in the Human Heart: Precision and Accuracy of in vivo Proton Magnetic Resonance Spectroscopy
Published in Journal of magnetic resonance imaging (01-08-2021)“…Background Proton magnetic resonance spectroscopy (1H‐MRS) of the human heart is deemed to be a quantitative method to investigate myocardial metabolite…”
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Subclinical effects of long‐chain fatty acid β‐oxidation deficiency on the adult heart: A case‐control magnetic resonance study
Published in Journal of inherited metabolic disease (01-09-2020)“…Cardiomyopathy can be a severe complication in patients with long‐chain fatty acid β‐oxidation disorders (LCFAOD), particularly during episodes of metabolic…”
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Small animal cardiovascular MR imaging and spectroscopy
Published in Progress in nuclear magnetic resonance spectroscopy (01-08-2015)“…The use of MR imaging and spectroscopy for studying cardiovascular disease processes in small animals has increased tremendously over the past decade. This is…”
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In vivo proton T1 relaxation times of mouse myocardial metabolites at 9.4 T
Published in Magnetic resonance in medicine (01-06-2015)“…Purpose Proton magnetic resonance spectroscopy (1H‐MRS) for quantitative in vivo assessment of mouse myocardial metabolism requires accurate acquisition timing…”
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Carnitine supplementation attenuates myocardial lipid accumulation in long-chain acyl-CoA dehydrogenase knockout mice
Published in Journal of inherited metabolic disease (01-11-2013)“…Purpose Elevation of long-chain acylcarnitine levels is a hallmark of long-chain mitochondrial β-oxidation (FAO) disorders, and can be accompanied by secondary…”
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