Search Results - "Baker, Robert K"

Protocol development to further differentiate and transition stem cell-derived pancreatic progenitors from a monolayer into endocrine cells in suspension culture by Braam, Mitchell J. S., Zhao, Jia, Liang, Shenghui, Ida, Shogo, Kloostra, Nick K., Iworima, Diepiriye G., Tang, Mei, Baker, Robert K., Quiskamp, Nina, Piret, James M., Kieffer, Timothy J.

“…The generation of functional β-cells from human pluripotent stem cells (hPSCs) for cell replacement therapy and disease modeling of diabetes is being…”
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FGF21-Mediated Improvements in Glucose Clearance Require Uncoupling Protein 1 by Kwon, Michelle M., O’Dwyer, Shannon M., Baker, Robert K., Covey, Scott D., Kieffer, Timothy J.

“…Fibroblast growth factor 21 (FGF21)-mediated weight loss and improvements in glucose metabolism correlate with increased uncoupling protein 1 (Ucp1) levels in…”
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The Impact of Different Implantation Sites and Sex on the Differentiation of Human Pancreatic Endoderm Cells Into Insulin-Secreting Cells In Vivo by Saber, Nelly, Ellis, Cara E, Iworima, Diepiriye G, Baker, Robert K, Rezania, Alireza, Kieffer, Timothy J

“…Few studies have examined the differentiation of human embryonic stem cell (hESC)-derived pancreatic endoderm cells (PECs) in different implantation sites…”
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PDX1+ cell budding morphogenesis in a stem cell-derived islet spheroid system by Zhao, Jia, Liang, Shenghui, Cen, Haoning Howard, Li, Yanjun, Baker, Robert K., Ruprai, Balwinder, Gao, Guang, Zhang, Chloe, Ren, Huixia, Tang, Chao, Chen, Liangyi, Liu, Yanmei, Lynn, Francis C., Johnson, James D., Kieffer, Timothy J.

“…Remarkable advances in protocol development have been achieved to manufacture insulin-secreting islets from human pluripotent stem cells (hPSCs). Distinct from…”
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The Role of ARX in Human Pancreatic Endocrine Specification by Gage, Blair K, Asadi, Ali, Baker, Robert K, Webber, Travis D, Wang, Rennian, Itoh, Masayuki, Hayashi, Masaharu, Miyata, Rie, Akashi, Takumi, Kieffer, Timothy J

“…The in vitro differentiation of human embryonic stem cells (hESCs) offers a model system to explore human development. Humans with mutations in the…”
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Metabolic switching, growth kinetics and cell yields in the scalable manufacture of stem cell-derived insulin-producing cells by Iworima, Diepiriye G, Baker, Robert K, Ellis, Cara, Sherwood, Chris, Zhan, Lisa, Rezania, Alireza, Piret, James M, Kieffer, Timothy J

“…Diabetes is a disease affecting over 500 million people globally due to insulin insufficiency or insensitivity. For individuals with type 1 diabetes,…”
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Role of myeloid cell leptin signaling in the regulation of glucose metabolism by Pereira, Sandra, Cline, Daemon L., Chan, Melissa, Chai, Kalin, Yoon, Ji Soo, O’Dwyer, Shannon M., Ellis, Cara E., Glavas, Maria M., Webber, Travis D., Baker, Robert K., Erener, Suheda, Covey, Scott D., Kieffer, Timothy J.

“…Although innate immunity is linked to metabolic health, the effect of leptin signaling in cells from the innate immune system on glucose homeostasis has not…”
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Analysis of the effects of bench-scale cell culture platforms and inoculum cell concentrations on PSC aggregate formation and culture by Iworima, Diepiriye G, Baker, Robert K, Piret, James M, Kieffer, Timothy J

“…Human pluripotent stem cells (hPSCs) provide many opportunities for application in regenerative medicine due to their ability to differentiate into cells from…”
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AAV GCG-EGFP, a new tool to identify glucagon-secreting α-cells by Tudurí, Eva, Glavas, Maria M., Asadi, Ali, Baker, Robert K., Ellis, Cara E., Soukhatcheva, Galina, Philit, Marjolaine, Huynh, Frank K., Johnson, James D., Bruce Verchere, C., Kieffer, Timothy J.

“…The study of primary glucagon-secreting α-cells is hampered by their low abundance and scattered distribution in rodent pancreatic islets. We have designed a…”
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Identification of RING finger protein 4 (RNF4) as a modulator of DNA demethylation through a functional genomics screen by Hu, Xiaoyi V., Rodrigues, Tânia M. A., Tao, Haiyan, Baker, Robert K., Miraglia, Loren, Orth, Anthony P., Lyons, Gary E., Schultz, Peter G., Wu, Xu

“…DNA methylation is an important epigenetic modification involved in transcriptional regulation, nuclear organization, development, aging, and disease. Although…”
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Anatomic characteristics of ruptured abdominal aortic aneurysm on conventional CT scans: implications for rupture risk by Fillinger, Mark F, Racusin, Jessica, Baker, Robert K, Cronenwett, Jack L, Teutelink, Arno, Schermerhorn, Marc L, Zwolak, Robert M, Powell, Richard J, Walsh, Daniel B, Rzucidlo, Eva M

“…The purpose of this study was to analyze anatomic characteristics of patients with ruptured abdominal aortic aneurysms (AAAs), with conventional…”
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Deletion of pancreas-specific miR-216a reduces beta-cell mass and inhibits pancreatic cancer progression in mice by Erener, Suheda, Ellis, Cara E., Ramzy, Adam, Glavas, Maria M., O’Dwyer, Shannon, Pereira, Sandra, Wang, Tom, Pang, Janice, Bruin, Jennifer E., Riedel, Michael J., Baker, Robert K., Webber, Travis D., Lesina, Marina, Blüher, Matthias, Algül, Hana, Kopp, Janel L., Herzig, Stephan, Kieffer, Timothy J.

“…miRNAs have crucial functions in many biological processes and are candidate biomarkers of disease. Here, we show that miR-216a is a conserved,…”
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Overexpression of PAX4 reduces glucagon expression in differentiating hESCs by Gage, Blair K, Baker, Robert K, Kieffer, Timothy J

“…Human embryonic stem cells (hESCs) are pluripotent and capable of generating new β-cells, but current in vitro differentiation protocols generally fail to…”
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Insulin Null β-cells Have a Prohormone Processing Defect That Is Not Reversed by AAV Rescue of Proinsulin Expression by Ramzy, Adam, Edeer, Nazde, Baker, Robert K, O’Dwyer, Shannon, Mojibian, Majid, Verchere, C Bruce, Kieffer, Timothy J

“…Up to 6% of diabetes has a monogenic cause including mutations in the insulin gene, and patients are candidates for a gene therapy. Using a mouse model of…”
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Differentiation of stem cell-derived pancreatic progenitors into insulin-secreting islet clusters in a multiwell-based static 3D culture system by Liang, Shenghui, Zhao, Jia, Baker, Robert K., Tran, Elisa, Zhan, Lisa, Kieffer, Timothy J.

“…Orbital shaker-based suspension culture systems have been in widespread use for differentiating human pluripotent stem cell (hPSC)-derived pancreatic…”
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Differentiation of Human Pluripotent Stem Cells into Insulin-Producing Islet Clusters by Zhao, Jia, Liang, Shenghui, Braam, Mitchell J S, Baker, Robert K, Iworima, Diepiriye G, Quiskamp, Nina, Kieffer, Timothy J

“…Differentiation of human pluripotent stem cells (hPSCs) into insulin-secreting beta cells provides material for investigating beta cell function and diabetes…”
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AAV8 Ins1-Cre can produce efficient β-cell recombination but requires consideration of off-target effects by Ramzy, Adam, Tudurí, Eva, Glavas, Maria M., Baker, Robert K., Mojibian, Majid, Fox, Jessica K., O’Dwyer, Shannon M., Dai, Derek, Hu, Xiaoke, Denroche, Heather C., Edeer, Nazde, Gray, Sarah L., Verchere, Cameron B., Johnson, James D., Kieffer, Timothy J.

“…In vivo genetic manipulation is used to study the impact of gene deletion or re-expression on β-cell function and organism physiology. Cre-LoxP is a system…”
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Metabolic effects of leptin receptor knockdown or reconstitution in adipose tissues by Pereira, Sandra, O’Dwyer, Shannon M., Webber, Travis D., Baker, Robert K., So, Victor, Ellis, Cara E., Yoon, Ji Soo, Mojibian, Majid, Glavas, Maria M., Karunakaran, Subashini, Clee, Susanne M., Covey, Scott D., Kieffer, Timothy J.

“…The relative contribution of peripheral and central leptin signalling to the regulation of metabolism and the mechanisms through which leptin affects glucose…”
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IGFBP2 Is Neither Sufficient nor Necessary for the Physiological Actions of Leptin on Glucose Homeostasis in Male ob/ob Mice by Neumann, Ursula H, Chen, Sam, Tam, Yuen Yi C, Baker, Robert K, Covey, Scott D, Cullis, Pieter R, Kieffer, Timothy J

“…The ability of leptin to improve metabolic abnormalities in models of leptin deficiency, lipodystrophy, and even type 1 diabetes is of significant interest…”
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Overexpression of PPARγ Specifically in Pancreatic β-Cells Exacerbates Obesity-Induced Glucose Intolerance, Reduces β-Cell Mass, and Alters Islet Lipid Metabolism in Male Mice by Hogh, K-Lynn N, Craig, Michael N, Uy, Christopher E, Nygren, Heli, Asadi, Ali, Speck, Madeline, Fraser, Jordie D, Rudecki, Alexander P, Baker, Robert K, Orešič, Matej, Gray, Sarah L

“…The contribution of peroxisomal proliferator-activated receptor (PPAR)-γ agonism in pancreatic β-cells to the antidiabetic actions of thiazolidinediones has…”
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