Incidence of Endogenous Fungal Endophthalmitis in Screening Dilated Exams in Patients with Elevated Beta-D-Glucan Levels versus Positive Fungal Blood Cultures

Incidence of Endogenous Fungal Endophthalmitis in Screening Dilated Exams in Patients with Elevated Beta-D-Glucan Levels versus Positive Fungal Blood Cultures

Purpose: Endogenous endophthalmitis is a severe intraocular infectious condition requiring rapid diagnosis and treatment. This study examines the incidence of fungal endophthalmitis in patients with elevated beta-D-glucan (BG) levels and those with positive blood culture and the utility of ophthalmo...

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Bibliographic Details
Published in:Clinical ophthalmology (Auckland, N.Z.) Vol. 16; pp. 2743 - 2750
Main Authors: Govindaraju, Viren K, Chao, Jonathan T, Duvall, Elizabeth R, Baker, Nicolas S, Fahey, Kelly M, Lee, Ramon, Williams, George A, Stec, Lori A
Format: Journal Article
Language:English
Published: Auckland Dove Medical Press Limited 31-08-2022
Taylor & Francis Ltd
Dove
Dove Medical Press
Subjects:
Blood
candidemia
chorioretinitis
Diabetes
Endophthalmitis
Fungal infections
Gas industry
infectious disease
Infectious diseases
Inflammation
Medical examination
Medical research
Medicine, Experimental
Ophthalmology
Original Research
Patients
Substance abuse treatment
United Kingdom
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Summary:Purpose: Endogenous endophthalmitis is a severe intraocular infectious condition requiring rapid diagnosis and treatment. This study examines the incidence of fungal endophthalmitis in patients with elevated beta-D-glucan (BG) levels and those with positive blood culture and the utility of ophthalmology consultation in these patients. Methods: Single center retrospective consecutive cohort study was conducted on patients at Beaumont Health from 2016-2021 who either had positive fungal blood cultures or an elevated BG level. Results: A total of 147 patients were examined by the ophthalmology department where 30 patients had an elevated BG level and 100 patients had a positive fungal blood culture. Incidence of fungal endophthalmitis was 0% in the elevated BG group and 1.5% in the positive fungal culture group, corresponding to a relative risk ratio of 0.0 (p = 0.31). Conclusion: BG testing may be useful in diagnosing isolated cases outside the standard screening paradigm, however the data within this study support the conclusion that there is no compelling evidence at this time to add or use BG as a surrogate for endophthalmitis screening. Further studies are required to further elucidate the role of BG in the care of critically ill patients. Keywords: endophthalmitis, candidemia, chorioretinitis, infectious disease
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ISSN:1177-5483
1177-5467
1177-5483
DOI:10.2147/OPTH.S362888