Search Results - "Baker, Matthew C."

Distinct brain transcriptome profiles in C9orf72-associated and sporadic ALS by Prudencio, Mercedes, Belzil, Veronique V, Batra, Ranjan, Ross, Christian A, Gendron, Tania F, Pregent, Luc J, Murray, Melissa E, Overstreet, Karen K, Piazza-Johnston, Amelia E, Desaro, Pamela, Bieniek, Kevin F, DeTure, Michael, Lee, Wing C, Biendarra, Sherri M, Davis, Mary D, Baker, Matthew C, Perkerson, Ralph B, van Blitterswijk, Marka, Stetler, Caroline T, Rademakers, Rosa, Link, Christopher D, Dickson, Dennis W, Boylan, Kevin B, Li, Hu, Petrucelli, Leonard

“…Evidence suggests that aberrant RNA processing contributes to amyotrophic lateral sclerosis (ALS). Using RNA sequencing, Prudencio et al . assessed the extent…”
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Reduced C9orf72 gene expression in c9FTD/ALS is caused by histone trimethylation, an epigenetic event detectable in blood by Belzil, Veronique V., Bauer, Peter O., Prudencio, Mercedes, Gendron, Tania F., Stetler, Caroline T., Yan, Irene K., Pregent, Luc, Daughrity, Lillian, Baker, Matthew C., Rademakers, Rosa, Boylan, Kevin, Patel, Tushar C., Dickson, Dennis W., Petrucelli, Leonard

“…Individuals carrying (GGGGCC) expanded repeats in the C9orf72 gene represent a significant portion of patients suffering from amyotrophic lateral sclerosis…”
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Neutralizing anti–IL-1 receptor antagonist autoantibodies induce inflammatory and fibrotic mediators in IgG4-related disease by Jarrell, Justin A., Baker, Matthew C., Perugino, Cory A., Liu, Hang, Bloom, Michelle S., Maehara, Takashi, Wong, Heidi H., Lanz, Tobias V., Adamska, Julia Z., Kongpachith, Sarah, Sokolove, Jeremy, Stone, John H., Pillai, Shiv S., Robinson, William H.

“…IgG4-related disease (IgG4-RD) is a fibroinflammatory condition involving loss of B-cell tolerance and production of autoantibodies. However, the relevant…”
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Association between repeat sizes and clinical and pathological characteristics in carriers of C9ORF72 repeat expansions (Xpansize-72): a cross-sectional cohort study by van Blitterswijk, Marka, PhD, DeJesus-Hernandez, Mariely, BS, Niemantsverdriet, Ellis, BS, Murray, Melissa E, PhD, Heckman, Michael G, MS, Diehl, Nancy N, BS, Brown, Patricia H, MS, Baker, Matthew C, BSc, Finch, NiCole A, MS, Bauer, Peter O, PhD, Serrano, Geidy, PhD, Beach, Thomas G, Prof, Josephs, Keith A, Prof, Knopman, David S, Prof, Petersen, Ronald C, Prof, Boeve, Bradley F, Prof, Graff-Radford, Neill R, Prof, Boylan, Kevin B, MD, Petrucelli, Leonard, Prof, Dickson, Dennis W, Prof, Rademakers, Rosa, Dr

“…Summary Background Hexanucleotide repeat expansions in chromosome 9 open reading frame 72 ( C9ORF72 ) are the most common known genetic cause of frontotemporal…”
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Jump from Pre-mutation to Pathologic Expansion in C9orf72 by Xi, Zhengrui, van Blitterswijk, Marka, Zhang, Ming, McGoldrick, Philip, McLean, Jesse R., Yunusova, Yana, Knock, Erin, Moreno, Danielle, Sato, Christine, McKeever, Paul M., Schneider, Raphael, Keith, Julia, Petrescu, Nicolae, Fraser, Paul, Tartaglia, Maria Carmela, Baker, Matthew C., Graff-Radford, Neill R., Boylan, Kevin B., Dickson, Dennis W., Mackenzie, Ian R., Rademakers, Rosa, Robertson, Janice, Zinman, Lorne, Rogaeva, Ekaterina

“…An expanded G4C2 repeat in C9orf72 represents the most common known genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration…”
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Lewy Body Disease is a Contributor to Logopenic Progressive Aphasia Phenotype by Buciuc, Marina, Whitwell, Jennifer L., Kasanuki, Koji, Graff‐Radford, Jonathan, Machulda, Mary M., Duffy, Joseph R., Strand, Edythe A., Lowe, Val J., Graff‐Radford, Neill R., Rush, Beth K., Franczak, Malgorzata B., Flanagan, Margaret E., Baker, Matthew C., Rademakers, Rosa, Ross, Owen A., Ghetti, Bernardino F., Parisi, Joseph E., Raghunathan, Aditya, Reichard, R. Ross, Bigio, Eileen H., Dickson, Dennis W., Josephs, Keith A.

“…Objective The objective of this study was to describe clinical features, [18F]‐fluorodeoxyglucose (FDG)‐positron emission tomography (PET) metabolism and…”
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CD52 Is Elevated on B cells of SLE Patients and Regulates B Cell Function by Bhamidipati, Kartik, Silberstein, John L, Chaichian, Yashaar, Baker, Matthew C, Lanz, Tobias V, Zia, Amin, Rasheed, Yusuf S, Cochran, Jennifer R, Robinson, William H

“…Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by B cell dysregulation and breaks in tolerance that lead to the production of…”
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Increased double-negative αβ+ T-cells reveal adult-onset autoimmune lymphoproliferative syndrome in a patient with IgG4-related disease by Brar, Nivaz, Spinner, Michael A, Baker, Matthew C, Advani, Ranjana H, Natkunam, Yasodha, Lewis, David B, Silva, Oscar

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Elevated methylation levels, reduced expression levels, and frequent contractions in a clinical cohort of C9orf72 expansion carriers by Jackson, Jazmyne L, Finch, NiCole A, Baker, Matthew C, Kachergus, Jennifer M, DeJesus-Hernandez, Mariely, Pereira, Kimberly, Christopher, Elizabeth, Prudencio, Mercedes, Heckman, Michael G, Thompson, E Aubrey, Dickson, Dennis W, Shah, Jaimin, Oskarsson, Björn, Petrucelli, Leonard, Rademakers, Rosa, van Blitterswijk, Marka

“…A repeat expansion in the C9orf72-SMCR8 complex subunit (C9orf72) is the most common genetic cause of two debilitating neurodegenerative diseases: amyotrophic…”
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Biologics Initiation in Rheumatoid Arthritis by Race and Ethnicity: Results From a Randomized Survey Study by Simard, Julia F., Lu, Rong, Falasinnu, Titilola O., Baker, Matthew C., Hawa, Saadiya, Deluna, Mariani D., Horomanski, Audra, Fairchild, Robert M.

“…Objective To investigate whether the race and ethnicity of a patient with rheumatoid arthritis (RA) influences rheumatologists’ likelihood of choosing to…”
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Clinical and neuroimaging biomarkers of amyloid-negative logopenic primary progressive aphasia by Whitwell, Jennifer L., Duffy, Joseph R., Strand, Edythe A., Machulda, Mary M., Senjem, Matthew L., Schwarz, Christopher G., Reid, Robert, Baker, Matthew C., Perkerson, Ralph B., Lowe, Val J., Rademakers, Rosa, Jack, Clifford R., Josephs, Keith A.

“…•Logopenic aphasia is usually, although not always, associated with Alzheimer disease.•Neuroimaging features differed between lvPPA patients with and without…”
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Diffuse argyrophilic grain disease with TDP-43 proteinopathy and neuronal intermediate filament inclusion disease: FTLD with mixed tau, TDP-43 and FUS pathologies by Koga, Shunsuke, Murakami, Aya, Soto-Beasley, Alexandra I, Walton, Ronald L, Baker, Matthew C, Castanedes-Casey, Monica, Josephs, Keith A, Ross, Owen A, Dickson, Dennis W

“…Frontotemporal lobar degeneration (FTLD) is a group of disorders characterized by degeneration of the frontal and temporal lobes, leading to progressive…”
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Publisher Correction to: Diffuse argyrophilic grain disease with TDP-43 proteinopathy and neuronal intermediate filament inclusion disease: FTLD with mixed tau, TDP-43 and FUS pathologies by Koga, Shunsuke, Murakami, Aya, Soto-Beasley, Alexandra I, Walton, Ronald L, Baker, Matthew C, Castanedes-Casey, Monica, Josephs, Keith A, Ross, Owen A, Dickson, Dennis W

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Progranulin-associated PiB-negative logopenic primary progressive aphasia by Josephs, Keith A., Duffy, Joseph R., Strand, Edythe A., Machulda, Mary M., Vemuri, Prashanthi, Senjem, Matthew L., Perkerson, Ralph B., Baker, Matthew C., Lowe, Val, Jack, Clifford R., Rademakers, Rosa, Whitwell, Jennifer L.

“…The logopenic variant of primary progressive aphasia (lvPPA) strongly associates with Alzheimer’s disease, but can also associate with frontotemporal lobar…”
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Extensive transcriptomic study emphasizes importance of vesicular transport in C9orf72 expansion carriers by Dickson, Dennis W, Baker, Matthew C, Jackson, Jazmyne L, DeJesus-Hernandez, Mariely, Finch, NiCole A, Tian, Shulan, Heckman, Michael G, Pottier, Cyril, Gendron, Tania F, Murray, Melissa E, Ren, Yingxue, Reddy, Joseph S, Graff-Radford, Neill R, Boeve, Bradley F, Petersen, Ronald C, Knopman, David S, Josephs, Keith A, Petrucelli, Leonard, Oskarsson, Björn, Sheppard, John W, Asmann, Yan W, Rademakers, Rosa, van Blitterswijk, Marka

“…The majority of the clinico-pathological variability observed in patients harboring a repeat expansion in the C9orf72-SMCR8 complex subunit (C9orf72) remains…”
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Case report of a patient with unclassified tauopathy with molecular and neuropathological features of both progressive supranuclear palsy and corticobasal degeneration by Koga, Shunsuke, Metrick, 2nd, Michael A, Golbe, Lawrence I, Santambrogio, Alessia, Kim, Minji, Soto-Beasley, Alexandra I, Walton, Ronald L, Baker, Matthew C, De Castro, Cristhoper Fernandez, DeTure, Michael, Russell, David, Navia, Bradford A, Sandiego, Christine, Ross, Owen A, Vendruscolo, Michele, Caughey, Byron, Dickson, Dennis W

“…Progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) are distinct clinicopathological subtypes of frontotemporal lobar degeneration. They…”
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Repurposing drugs for the treatment of osteoarthritis by Kuswanto, Wilson, Baker, Matthew C.

“…Currently, no disease-modifying therapies for osteoarthritis (OA) exist, and attempts to identify novel cellular targets have been challenging. Risk factors…”
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Microglia in frontotemporal lobar degeneration with progranulin or C9ORF72 mutations by Sakae, Nobutaka, Roemer, Shanu F., Bieniek, Kevin F., Murray, Melissa E., Baker, Matthew C., Kasanuki, Koji, Graff‐Radford, Neill R., Petrucelli, Leonard, Van Blitterswijk, Marka, Rademakers, Rosa, Dickson, Dennis W.

“…Objective To identify clinicopathological differences between frontotemporal lobar degeneration (FTLD) due to mutations in progranulin (FTLD‐GRN) and…”
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The Third Dose Is the Charm: Effective Cellular and Humoral Immune Responses to Third COVID-19 Vaccine Doses in Immunosuppressed Nonresponders by Kuswanto, Wilson, Baker, Matthew C

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Prevalence and significance of pulmonary disease on lung ultrasonography in outpatients with SARS-CoV-2 infection by Fairchild, Robert M, Horomanski, Audra, Mar, Diane A, Triant, Gabriela R, Lu, Rong, Lu, Di, Guo, Haiwei Henry, Baker, Matthew C

“…BackgroundThe majority of patients with SARS-CoV-2 infection are diagnosed and managed as outpatients; however, little is known about the burden of pulmonary…”
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