Search Results - "Baker, Emily W."

Induced Pluripotent Stem Cell-Derived Neural Stem Cell Therapy Enhances Recovery in an Ischemic Stroke Pig Model by Baker, Emily W., Platt, Simon R., Lau, Vivian W., Grace, Harrison E., Holmes, Shannon P., Wang, Liya, Duberstein, Kylee Jo, Howerth, Elizabeth W., Kinder, Holly A., Stice, Steve L., Hess, David C., Mao, Hui, West, Franklin D.

“…Induced pluripotent stem cell-derived neural stem cells (iNSCs) have significant potential as an autologous, multifunctional cell therapy for stroke, which is…”
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The pig as a preclinical traumatic brain injury model: current models, functional outcome measures, and translational detection strategies by Kinder, Holly, Baker, Emily, West, Franklin

“…Traumatic brain injury (TBI) is a major contributor of long-term disability and a leading cause of death worldwide. A series of secondary injury cascades can…”
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Exploring the predictive value of lesion topology on motor function outcomes in a porcine ischemic stroke model by Scheulin, Kelly M., Jurgielewicz, Brian J., Spellicy, Samantha E., Waters, Elizabeth S., Baker, Emily W., Kinder, Holly A., Simchick, Gregory A., Sneed, Sydney E., Grimes, Janet A., Zhao, Qun, Stice, Steven L., West, Franklin D.

“…Harnessing the maximum diagnostic potential of magnetic resonance imaging (MRI) by including stroke lesion location in relation to specific structures that are…”
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Scaled traumatic brain injury results in unique metabolomic signatures between gray matter, white matter, and serum in a piglet model by Baker, Emily W, Henderson, W Matthew, Kinder, Holly A, Hutcheson, Jessica M, Platt, Simon R, West, Franklin D

“…Traumatic brain injury (TBI) is a leading cause of death and long-term disability in the United States. The heterogeneity of the disease coupled with the lack…”
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Identification of predictive MRI and functional biomarkers in a pediatric piglet traumatic brain injury model by Wang, Hongzhi, Baker, Emily, Mandal, Abhyuday, Pidaparti, Ramana, West, Franklin, Kinder, Holly

“…Traumatic brain injury (TBI) at a young age can lead to the development of long-term functional impairments. Severity of injury is well demonstrated to have a…”
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Semi-Automated Cell and Tissue Analyses Reveal Regionally Specific Morphological Alterations of Immune and Neural Cells in a Porcine Middle Cerebral Artery Occlusion Model of Stroke by Spellicy, Samantha E, Scheulin, Kelly M, Baker, Emily W, Jurgielewicz, Brian J, Kinder, Holly A, Waters, Elizabeth S, Grimes, Janet A, Stice, Steven L, West, Franklin D

“…Histopathological analysis of cellular changes in the stroked brain provides critical information pertaining to inflammation, cell death, glial scarring, and…”
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Human iNPC therapy leads to improvement in functional neurologic outcomes in a pig ischemic stroke model by Lau, Vivian W., Platt, Simon R., Grace, Harrison E., Baker, Emily W., West, Franklin D.

“…Introduction Stroke is the leading cause of disability in the United States but current therapies are limited with no regenerative potential. Previous…”
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Magnetic Resonance Imaging and Gait Analysis Indicate Similar Outcomes Between Yucatan and Landrace Porcine Ischemic Stroke Models by Sneed, Sydney E, Scheulin, Kelly M, Kaiser, Erin E, Fagan, Madison M, Jurgielewicz, Brian J, Waters, Elizabeth S, Spellicy, Samantha E, Duberstein, Kylee J, Platt, Simon R, Baker, Emily W, Stice, Steven L, Kinder, Holly A, West, Franklin D

“…The Stroke Therapy Academic Industry Roundtable (STAIR) has recommended that novel therapeutics be tested in a large animal model with similar anatomy and…”
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Neural stem cell therapy for stroke: A multimechanistic approach to restoring neurological function by Baker, Emily W., Kinder, Holly A., West, Franklin D.

“…Introduction Neural stem cells (NSCs) have demonstrated multimodal therapeutic function for stroke, which is the leading cause of long‐term disability and the…”
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Controlled Cortical Impact Severity Results in Graded Cellular, Tissue, and Functional Responses in a Piglet Traumatic Brain Injury Model by Baker, Emily W, Kinder, Holly A, Hutcheson, Jessica M, Duberstein, Kylee Jo J, Platt, Simon R, Howerth, Elizabeth W, West, Franklin D

“…A number of pre-clinical rodent models have been developed in an effort to recapitulate injury mechanisms and identify potential therapeutics for traumatic…”
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Abstract P763: A Precision Medicine Approach to Intracerebral Stem Cell Transplantation Utilizing Lesion Topology in a Porcine Model of Ischemic Stroke by Scheulin, Kelly M, Jurgielewicz, Brian J, Saini, Monika, Spellicy, Samantha E, Waters, Elizabeth S, Baker, Emily W, Kinder, Holly A, Simchick, Gregory A, Sneed, Sydney E, Zhao, Qun, Stice, Steven L, West, Franklin D

“…Despite the devastating global impact of ischemic stroke, there are few Food and Drug Administration (FDA) approved treatments, none of which are capable of…”
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Abstract WP115: Transplanted Induced Neural Stem Cells Differentiate and Integrate Into the Brain Parenchyma of Ischemic Stroke Pigs Leading to Improved Tissue Recovery by Baker, Emily W, Platt, Simon R, Holmes, Shannon P, Wang, Liya, Lau, Vivian W, Grace, Harrison E, Kinder, Holly A, Howerth, Elizabeth W, Duberstein, Kylee Jo J, Stice, Steven L, Hess, David C, Mao, Hui, West, Franklin D

“…Abstract only Studies in rodents have provided evidence that induced pluripotent stem cell derived neural stem cells (iNSCs) have a multifunctional role in…”
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Abstract 130: Induced Neural Stem Cell Treated Stroke Pigs Show Improved White Matter Integrity and Brain Metabolism Post-ischemic Stroke by West, Franklin D, Platt, Simon R, Holmes, Shannon P, Wang, Liya, Lau, Vivian W, Baker, Emily W, Grace, Harrison E, Howerth, Elizabeth W, Duberstein, Kylee J, Stice, Steven L, Hess, David C, Mao, Hui

“…Abstract only Recent studies in rodent stroke models have shown that induced pluripotent stem cell derived neural stem cells (iNSCs) can lead to a significant…”
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Abstract TP109: Quantitative Gait Analysis Demonstrates Significant Changes in Motor Function Post-ischemic Stroke and Simulated Intraparenchymal Therapeutic Delivery in a Porcine Model by Kaiser, Erin E, Duberstein, Kylee J, Platt, Simon R, Lau, Vivian W, Nguyen, Trinh, Baker, Emily W, Grace, Harrison E, Howerth, Elizabeth W, Holmes, Shannon P, Wang, Liya, Stice, Steve L, Mao, Hui, West, Franklin D

“…Abstract only Severity of stroke and subsequent recovery can be measured through gait changes of affected individuals. Recent failures of therapies tested in…”
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