The effects of enriched environment on the behavioral and corticosterone response to methamphetamine in adolescent and adult mice

Methamphetamine alters behavior and the stress response system. Relatively little research has examined the effects of methamphetamine in adolescents and compared these effects to those in adults. Housing in enriched environments has been explored as one way to protect against the effects of methamp...

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Bibliographic Details
Published in:	Developmental psychobiology Vol. 60; no. 6; pp. 664 - 673
Main Authors:	Baker, Elizabeth P., Magnuson, Elliott C., Dahly, Ashley M., Siegel, Jessica A.
Format:	Journal Article
Language:	English
Published:	United States 01-09-2018
Subjects:	adolescent Age Factors Animals Anxiety - chemically induced Anxiety - drug therapy Anxiety - physiopathology Behavior, Animal - drug effects behavioral despair Central Nervous System Stimulants - administration & dosage Central Nervous System Stimulants - pharmacology Corticosterone Depression - chemically induced Depression - drug therapy Depression - physiopathology environmental enrichment Male methamphetamine Methamphetamine - administration & dosage Methamphetamine - pharmacology Mice Mice, Inbred C57BL Social Behavior Social Environment Social Isolation environmental enrichment adolescent behavioral despair methamphetamine mice
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Summary:	Methamphetamine alters behavior and the stress response system. Relatively little research has examined the effects of methamphetamine in adolescents and compared these effects to those in adults. Housing in enriched environments has been explored as one way to protect against the effects of methamphetamine, but the findings are conflicting and no study has examined how enriched environment may alter the behavioral and corticosterone responses to methamphetamine in adolescent and adult rodents. We examined the long‐term effects of methamphetamine exposure on anxiety, social behavior, behavioral despair, and corticosterone levels in adolescent and adult mice housed in enriched or isolated environments. Enriched environment did not alter the behavioral or corticosterone response to methamphetamine. Methamphetamine exposure decreased anxiety and increased behavioral despair in adult mice, but methamphetamine did not alter behavior in adolescent mice. There was no effect of methamphetamine on social behavior or corticosterone levels. Our findings demonstrate that the specific environmental enrichment paradigm used in this study was not sufficient to mitigate the behavioral effects of methamphetamine and that adolescent mice are relatively resistant to the effects of methamphetamine compared to adult mice.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0012-1630 1098-2302
DOI:	10.1002/dev.21633