Search Results - "Baker, Darren P."

Brain Endothelial- and Epithelial-Specific Interferon Receptor Chain 1 Drives Virus-Induced Sickness Behavior and Cognitive Impairment by Blank, Thomas, Detje, Claudia N., Spieß, Alena, Hagemeyer, Nora, Brendecke, Stefanie M., Wolfart, Jakob, Staszewski, Ori, Zöller, Tanja, Papageorgiou, Ismini, Schneider, Justus, Paricio-Montesinos, Ricardo, Eisel, Ulrich L.M., Manahan-Vaughan, Denise, Jansen, Stephan, Lienenklaus, Stefan, Lu, Bao, Imai, Yumiko, Müller, Marcus, Goelz, Susan E., Baker, Darren P., Schwaninger, Markus, Kann, Oliver, Heikenwalder, Mathias, Kalinke, Ulrich, Prinz, Marco

“…Sickness behavior and cognitive dysfunction occur frequently by unknown mechanisms in virus-infected individuals with malignancies treated with type I…”
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Influenza B virus non-structural protein 1 counteracts ISG15 antiviral activity by sequestering ISGylated viral proteins by Zhao, Chen, Sridharan, Haripriya, Chen, Ran, Baker, Darren P., Wang, Shanshan, Krug, Robert M.

“…The ubiquitin-like protein ISG15 and its conjugation to proteins (ISGylation) are strongly induced by type I interferon. Influenza B virus encodes…”
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Function of Mitochondrial Stat3 in Cellular Respiration by Wegrzyn, Joanna, Potla, Ramesh, Chwae, Yong-Joon, Sepuri, Naresh B.V, Zhang, Qifang, Koeck, Thomas, Derecka, Marta, Szczepanek, Karol, Szelag, Magdalena, Gornicka, Agnieszka, Moh, Akira, Moghaddas, Shadi, Chen, Qun, Bobbili, Santha, Cichy, Joanna, Dulak, Jozef, Baker, Darren P, Wolfman, Alan, Stuehr, Dennis, Hassan, Medhat O, Fu, Xin-Yuan, Avadhani, Narayan, Drake, Jennifer I, Fawcett, Paul, Lesnefsky, Edward J, Larner, Andrew C

“…Cytokines such as interleukin-6 induce tyrosine and serine phosphorylation of Stat3 that results in activation of Stat3-responsive genes. We provide evidence…”
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Viral infection augments Nod1/2 signaling to potentiate lethality associated with secondary bacterial infections by Kim, Yun-Gi, Park, Jong-Hwan, Reimer, Thornik, Baker, Darren P, Kawai, Taro, Kumar, Himanshu, Akira, Shizuo, Wobus, Christiane, Núñez, Gabriel

“…Secondary bacterial infection is a common sequela to viral infection and is associated with increased lethality and morbidity. However, the underlying…”
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Ligand-Stimulated Downregulation of the Alpha Interferon Receptor: Role of Protein Kinase D2 by Zheng, Hui, Qian, Juan, Varghese, Bentley, Baker, Darren P., Fuchs, Serge

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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A Novel PEGylated Interferon Beta-1a for Multiple Sclerosis: Safety, Pharmacology, and Biology by Hu, Xiao, Miller, Larisa, Richman, Sandra, Hitchman, Stacy, Glick, Gabrielle, Liu, Shifang, Zhu, Ying, Crossman, Mary, Nestorov, Ivan, Gronke, Robert S., Baker, Darren P., Rogge, Mark, Subramanyam, Meena, Davar, Gudarz

“…This study clinically evaluated a novel PEGylated form of interferon beta-1a (PEG-IFN beta-1a), a potential first-line treatment for relapsing multiple…”
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Role of the Akt pathway in mRNA translation of interferon-stimulated genes by Kaur, Surinder, Sassano, Antonella, Dolniak, Blazej, Joshi, Sonali, Majchrzak-Kita, Beata, Baker, Darren P, Hay, Nissim, Fish, Eleanor N, Platanias, Leonidas C

“…Multiple signaling pathways are engaged by the type I and II IFN receptors, but their specific roles and possible coordination in the generation of…”
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Central role of ULK1 in type I interferon signaling by Saleiro, Diana, Mehrotra, Swarna, Kroczynska, Barbara, Beauchamp, Elspeth M, Lisowski, Pawel, Majchrzak-Kita, Beata, Bhagat, Tushar D, Stein, Brady L, McMahon, Brandon, Altman, Jessica K, Kosciuczuk, Ewa M, Baker, Darren P, Jie, Chunfa, Jafari, Nadereh, Thompson, Craig B, Levine, Ross L, Fish, Eleanor N, Verma, Amit K, Platanias, Leonidas C

“…We provide evidence that the Unc-51-like kinase 1 (ULK1) is activated during engagement of the type I interferon (IFN) receptor (IFNR). Our studies demonstrate…”
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Interferon β-1a for the treatment of Ebola virus disease: A historically controlled, single-arm proof-of-concept trial by Konde, Mandy Kader, Baker, Darren P, Traore, Fode Amara, Sow, Mamadou Saliou, Camara, Alioune, Barry, Alpha Amadou, Mara, Doussou, Barry, Abdoulaye, Cone, Moussa, Kaba, Ibrahima, Richard, Amento Ablam, Beavogui, Abdoul Habib, Günther, Stephan, Pintilie, Melania, Fish, Eleanor N

“…To date there are no approved antiviral drugs for the treatment of Ebola virus disease (EVD). Based on our in vitro evidence of antiviral activity of…”
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Influenza virus non-structural protein 1 (NS1) disrupts interferon signaling by Jia, Danlin, Rahbar, Ramtin, Chan, Renee W Y, Lee, Suki M Y, Chan, Michael C W, Wang, Ben Xuhao, Baker, Darren P, Sun, Bing, Peiris, J S Malik, Nicholls, John M, Fish, Eleanor N

“…Type I interferons (IFNs) function as the first line of defense against viral infections by modulating cell growth, establishing an antiviral state and…”
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Interferon beta induces clearance of mutant ataxin 7 and improves locomotion in SCA7 knock-in mice by CHORT, Alice, ALVES, Sandro, RUBERG, Merle, JANER, Alexandre, STEVANIN, Giovanni, BRICE, Alexis, SITTLER, Annie, MARINELLO, Martina, DUFRESNOIS, Béatrice, DORNBIERER, Jean-Gabriel, TESSON, Christelle, LATOUCHE, Morwena, BAKER, Darren P, BARKATS, Martine, EL HACHIMI, Khalid H

“…We showed previously, in a cell model of spinocerebellar ataxia 7, that interferon beta induces the expression of PML protein and the formation of PML protein…”
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Pathogenic Effects of IFIT2 and Interferon-β during Fatal Systemic Candida albicans Infection by Stawowczyk, Marcin, Naseem, Shamoon, Montoya, Valeria, Baker, Darren P, Konopka, James, Reich, Nancy C

“…A balanced immune response to infection is essential to prevent the pathology and tissue damage that can occur from an unregulated or hyperactive host defense…”
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A Rapid Screening Assay Identifies Monotherapy with Interferon-ß and Combination Therapies with Nucleoside Analogs as Effective Inhibitors of Ebola Virus by McCarthy, Stephen D S, Majchrzak-Kita, Beata, Racine, Trina, Kozlowski, Hannah N, Baker, Darren P, Hoenen, Thomas, Kobinger, Gary P, Fish, Eleanor N, Branch, Donald R

“…To date there are no approved antiviral drugs for the treatment of Ebola virus disease (EVD). While a number of candidate drugs have shown limited efficacy in…”
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Tyrosine Phosphorylation of Protein Kinase D2 Mediates Ligand-inducible Elimination of the Type 1 Interferon Receptor by Zheng, Hui, Qian, Juan, Baker, Darren P., Fuchs, Serge Y.

“…Type 1 interferons (including IFNα/β) activate their cell surface receptor to induce the intracellular signal transduction pathways that play an important role…”
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Vascular endothelial growth factor–induced elimination of the type 1 interferon receptor is required for efficient angiogenesis by Zheng, Hui, Qian, Juan, Carbone, Christopher J., Leu, N. Adrian, Baker, Darren P., Fuchs, Serge Y.

“…Angiogenesis is stimulated by vascular endothelial growth factor (VEGF) and antagonized by type 1 interferons, including IFN-α/β. On engaging their respective…”
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Regulatory effects of mTORC2 complexes in type I IFN signaling and in the generation of IFN responses by Kaur, Surinder, Sassano, Antonella, Majchrzak-Kita, Beata, Baker, Darren P, Su, Bing, Fish, Eleanor N, Platanias, Leonidas C

“…IFNs transduce signals by binding to cell surface receptors and activating cellular pathways and regulatory networks that control transcription of…”
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Pathogen recognition receptor signaling accelerates phosphorylation-dependent degradation of IFNAR1 by Qian, Juan, Zheng, Hui, Huangfu, Wei-Chun, Liu, Jianghuai, Carbone, Christopher J, Leu, N Adrian, Baker, Darren P, Fuchs, Serge Y

“…An ability to sense pathogens by a number of specialized cell types including the dendritic cells plays a central role in host's defenses. Activation of these…”
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Protein tyrosine phosphatase 1B is a key regulator of IFNAR1 endocytosis and a target for antiviral therapies by Carbone, Christopher J, Zheng, Hui, Bhattacharya, Sabyasachi, Lewis, John R, Reiter, Alexander M, Henthorn, Paula, Zhang, Zhong-Yin, Baker, Darren P, Ukkiramapandian, Radha, Bence, Kendra K, Fuchs, Serge Y

“…Type 1 interferons (IFN1) elicit antiviral defenses by activating the cognate receptor composed of IFN-α/β receptor chain 1 (IFNAR1) and IFNAR2…”
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Free fatty acids induce ER stress and block antiviral activity of interferon alpha against hepatitis C virus in cell culture by Gunduz, Feyza, Aboulnasr, Fatma M, Chandra, Partha K, Hazari, Sidhartha, Poat, Bret, Baker, Darren P, Balart, Luis A, Dash, Srikanta

“…Hepatic steatosis is recognized as a major risk factor for liver disease progression and impaired response to interferon based therapy in chronic hepatitis C…”
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Regulatory Effects of Mammalian Target of Rapamycin-activated Pathways in Type I and II Interferon Signaling by Kaur, Surinder, Lal, Lakhvir, Sassano, Antonella, Majchrzak-Kita, Beata, Srikanth, Maya, Baker, Darren P., Petroulakis, Emmanuel, Hay, Nissim, Sonenberg, Nahum, Fish, Eleanor N., Platanias, Leonidas C.

“…The mechanisms regulating initiation of mRNA translation for the generation of protein products that mediate interferon (IFN) responses are largely unknown. We…”
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