Search Results - "Baker, Daniel L"
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Electrocatalytic and Photocatalytic Hydrogen Production in Aqueous Solution by a Molecular Cobalt Complex
Published in Angewandte Chemie International Edition (11-06-2012)“…A mononuclear cobalt complex supported by a new type of pentadentate ligand catalyzed the evolution of hydrogen in purely aqueous solution (see picture). This…”
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Understanding the Dissolution of Cellulose and Silk Fibroin in 1-ethyl-3-methylimidazolium Acetate and Dimethyl Sulphoxide for Application in Hybrid Films
Published in Materials (29-10-2024)“…This paper investigates the dissolution of two biopolymers, cellulose and silk fibroin, in a mixture of 1-ethyl-3-methylimidazolium acetate (EmimAc) and…”
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Cooperative Intramolecular Dynamics Control the Chain-Length-Dependent Glass Transition in Polymers
Published in Physical review. X (01-05-2022)“…The glass transition is a long-standing unsolved problem in materials science. For polymers, our understanding of glass formation is particularly poor because…”
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4
Gold Nanorods Carrying Paclitaxel for Photothermal-Chemotherapy of Cancer
Published in Bioconjugate chemistry (20-03-2013)“…Nanotechnology-based photothermal therapy has emerged as a promising treatment for cancer during the past decade. However, heterogeneous laser heating and…”
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5
G Protein-Coupled Receptor-Ligand Pose and Functional Class Prediction
Published in International journal of molecular sciences (01-07-2024)“…G protein-coupled receptor (GPCR) transmembrane protein family members play essential roles in physiology. Numerous pharmaceuticals target GPCRs, and many drug…”
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Highly Potent Non-Carboxylic Acid Autotaxin Inhibitors Reduce Melanoma Metastasis and Chemotherapeutic Resistance of Breast Cancer Stem Cells
Published in Journal of medicinal chemistry (23-02-2017)“…Autotaxin (ATX, aka. ENPP2) is the main source of the lipid mediator lysophosphatidic acid (LPA) in biological fluids. This study reports on inhibitors of ATX…”
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Building block aspect ratio controls assembly, architecture, and mechanics of synthetic and natural protein networks
Published in Nature communications (11-09-2023)“…Fibrous networks constructed from high aspect ratio protein building blocks are ubiquitous in nature. Despite this ubiquity, the functional advantage of such…”
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G protein-coupled receptors: the evolution of structural insight
Published in AIMS biophysics (01-01-2017)“…G protein-coupled receptors (GPCR) comprise a diverse superfamily of over 800 proteins that have gained relevance as biological targets for pharmaceutical drug…”
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2-Heptylcyclopropane-1-Carboxylic Acid Disperses and Inhibits Bacterial Biofilms
Published in Frontiers in microbiology (09-06-2021)“…Fatty-acid signaling molecules can inhibit biofilm formation, signal dispersal events, and revert dormant cells within biofilms to a metabolically active…”
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Synthesis and Characterization of 2-Decenoic Acid Modified Chitosan for Infection Prevention and Tissue Engineering
Published in Marine drugs (29-09-2021)“…Chitosan nanofiber membranes are recognized as functional antimicrobial materials, as they can effectively provide a barrier that guides tissue growth and…”
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Cis-2-Decenoic Acid and Bupivacaine Delivered from Electrospun Chitosan Membranes Increase Cytokine Production in Dermal and Inflammatory Cell Lines
Published in Pharmaceutics (01-10-2023)“…Wound dressings serve to protect tissue from contamination, alleviate pain, and facilitate wound healing. The biopolymer chitosan is an exemplary choice in…”
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Carba Analogs of Cyclic Phosphatidic Acid Are Selective Inhibitors of Autotaxin and Cancer Cell Invasion and Metastasis
Published in The Journal of biological chemistry (11-08-2006)“…Autotaxin (ATX, nucleotide pyrophosphate/phosphodiesterase-2) is an autocrine motility factor initially characterized from A2058 melanoma cell-conditioned…”
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The phospholipase A1 activity of lysophospholipase A-I links platelet activation to LPA production during blood coagulation[S]
Published in Journal of lipid research (01-05-2011)“…Platelet activation initiates an upsurge in polyunsaturated (18:2 and 20:4) lysophosphatidic acid (LPA) production. The biochemical pathway(s) responsible for…”
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Hits of a high-throughput screen identify the hydrophobic pocket of autotaxin/lysophospholipase D as an inhibitory surface
Published in Molecular pharmacology (01-09-2013)“…Autotaxin (ATX), a lysophospholipase D, plays an important role in cancer invasion, metastasis, tumor progression, tumorigenesis, neuropathic pain, fibrotic…”
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Optimization of a Pipemidic Acid Autotaxin Inhibitor
Published in Journal of medicinal chemistry (11-02-2010)“…Autotaxin (ATX, NPP2) has recently been shown to be the lysophospholipase D responsible for synthesis of the bioactive lipid lysophosphatidic acid (LPA). LPA…”
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Subtype-selective antagonists of lysophosphatidic Acid receptors inhibit platelet activation triggered by the lipid core of atherosclerotic plaques
Published in Circulation (New York, N.Y.) (12-08-2003)“…Lysophosphatidic acid (LPA) is a platelet-activating component of mildly oxidized LDL (mox-LDL) and lipids isolated from human atherosclerotic plaques…”
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Structure and catalytic function of sphingosine kinases: Analysis by site-directed mutagenesis and enzyme kinetics
Published in Biochimica et biophysica acta (01-01-2013)“…Sphingosine kinases 1 and 2 (SK1 and SK2) generate the bioactive lipid mediator sphingosine 1-phosphate and as such play a significant role in cell fate and in…”
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Pharmacophore Development and Application Toward the Identification of Novel, Small-Molecule Autotaxin Inhibitors
Published in Journal of medicinal chemistry (22-04-2010)“…Autotaxin (ATX) is a secreted glycoprotein with lysophospholipase D (LPLD) activity that generates the bioactive lipid lysophosphatidic acid (LPA) from…”
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Polymorphism of a Highly Asymmetrical Triacylglycerol in Milk Fat: 1‑Butyryl 2‑Stearoyl 3‑Palmitoyl-glycerol
Published in Crystal growth & design (05-10-2022)“…Milk fat has more than 200 triacylglycerols (TAGs), which play a pivotal role in its crystallization behavior. Asymmetrical TAGs containing short butyryl…”
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Virtual screening approaches for the identification of non-lipid autotaxin inhibitors
Published in Bioorganic & medicinal chemistry (15-02-2008)“…Autotaxin (ATX, NPP-2) catalyzes the conversion of lysophosphatidyl choline (LPC) to lysophosphatidic acid (LPA), a mitogenic cell survival factor that…”
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