Search Results - "Baker, DL"

GPCR homology model template selection benchmarking: Global versus local similarity measures by Castleman, Paige N., Sears, Chandler K., Cole, Judith A., Baker, Daniel L., Parrill, Abby L.

“…G protein-coupled receptors (GPCR) are integral membrane proteins of considerable interest as targets for drug development. GPCR ligand interaction studies…”
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Crystal Structure of a Cbf5-Nop10-Gar1 Complex and Implications in RNA-Guided Pseudouridylation and Dyskeratosis Congenita by Rashid, Rumana, Liang, Bo, Baker, Daniel L., Youssef, Osama A., He, Yang, Phipps, Kathleen, Terns, Rebecca M., Terns, Michael P., Li, Hong

“…H/ACA RNA-protein complexes, comprised of four proteins and an H/ACA guide RNA, modify ribosomal and small nuclear RNAs. The H/ACA proteins are also essential…”
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Neurodiversity, neurological disability and the public sector: notes on the autism spectrum by Baker, Dana Lee

“…Neurodiversity and neurological disabilities reflect rising public sector challenges. Both refer to the same set of medical conditions, but speak to different…”
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Late presentation of superior mesenteric artery syndrome following scoliosis surgery: a case report by Tsirikos, Athanasios I, Anakwe, Raymond E, Baker, Alexander D L

“…Obstruction of the third part of the duodenum by the superior mesenteric artery (SMA) can occur following surgical correction of scoliosis. The condition most…”
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RNA-guided RNA modification: functional organization of the archaeal H/ACA RNP by Baker, Daniel L, Youssef, Osama A, Chastkofsky, Michael I R, Dy, David A, Terns, Rebecca M, Terns, Michael P

“…In eukaryotes and archaea, uridines in various RNAs are converted to pseudouridines by RNA-guided RNA modification complexes termed H/ACA RNPs. Guide RNAs…”
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Lysophosphatidic Acid Induces Neointima Formation Through PPARγ Activation by Zhang, Chunxiang, Baker, Daniel L., Yasuda, Satoshi, Makarova, Natalia, Balazs, Louisa, Johnson, Leonard R., Marathe, Gopal K., McIntyre, Thomas M., Xu, Yong, Prestwich, Glenn D., Byun, Hoe-Sup, Bittman, Robert, Tigyi, Gabor

“…Neointimal lesions are characterized by accumulation of cells within the arterial wall and are a prelude to atherosclerotic disease. Here we report that a…”
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Targeting the hydrophobic pocket of autotaxin with virtual screening of inhibitors identifies a common aromatic sulfonamide structural motif by Fells, James I., Lee, Sue Chin, Norman, Derek D., Tsukahara, Ryoko, Kirby, Jason R., Nelson, Sandra, Seibel, William, Papoian, Ruben, Patil, Renukadevi, Miller, Duane D., Parrill, Abby L., Pham, Truc‐Chi, Baker, Daniel L., Bittman, Robert, Tigyi, Gabor

“…Modulation of autotaxin (ATX), the lysophospholipase D enzyme that produces lysophosphatidic acid, with small‐molecule inhibitors is a promising strategy for…”
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Subtype-selective antagonists of lysophosphatidic Acid receptors inhibit platelet activation triggered by the lipid core of atherosclerotic plaques by Rother, Enno, Brandl, Richard, Baker, Daniel L, Goyal, Pankaj, Gebhard, Harry, Tigyi, Gabor, Siess, Wolfgang

“…Lysophosphatidic acid (LPA) is a platelet-activating component of mildly oxidized LDL (mox-LDL) and lipids isolated from human atherosclerotic plaques…”
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Surgical treatment of scoliosis in Smith-Magenis syndrome: a case report by Tsirikos, Athanasios I, Baker, Alexander Dl, McClean, Claire

“…Smith-Magenis syndrome is a rare genetic condition associated with scoliosis in approximately 30% of cases. There is limited information in the literature on…”
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Direct Quantitative Analysis of Lysophosphatidic Acid Molecular Species by Stable Isotope Dilution Electrospray Ionization Liquid Chromatography–Mass Spectrometry by Baker, Daniel L., Desiderio, Dominic M., Miller, Duane D., Tolley, Betsy, Tigyi, Gabor J.

“…In order to better understand the role of lysophosphatidic acid (LPA) in physiology and pathophysiology, it is necessary to accurately determine the molecular…”
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Short-chain phosphatidates are subtype-selective antagonists of lysophosphatidic acid receptors by Fischer, D J, Nusser, N, Virag, T, Yokoyama, K, Wang Da, Baker, D L, Bautista, D, Parrill, A L, Tigyi, G

“…Lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P) are members of the phospholipid growth factor family. A major limitation in the field to date has…”
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Identification of Edg1 Receptor Residues That Recognize Sphingosine 1-Phosphate by Parrill, Abby L., Wang, De-an, Bautista, Debra L., Van Brocklyn, James R., Lorincz, Zsolt, Fischer, David J., Baker, Daniel L., Liliom, Karoly, Spiegel, Sarah, Tigyi, Gabor

“…Originating from its DNA sequence, a computational model of the Edg1 receptor has been developed that predicts critical interactions with its ligand,…”
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Learning to Adapt During a Surgical Mission to Remote Africa by Baker, Donna L.

“…The author describes a surgical mission to the Democratic Republic of the Congo…”
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Fibrin clot adhesion to dentin conditioned with protein constructs: an in vitro proof-of-principle study by Baker, David L., Stanley Pavlow, Sarah A., Wikesjö, Ulf M. E.

“…Objectives: Periodontal regeneration is contingent on the adsorption, uninterrupted adhesion, and maturation of a fibrin clot to a periodontally compromised…”
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Sphingosylphosphocholine is a naturally occurring lipid mediator in blood plasma: a possible role in regulating cardiac function via sphingolipid receptors by Liliom, K, Sun, G, Bünemann, M, Virág, T, Nusser, N, Baker, D L, Wang, D A, Fabian, M J, Brandts, B, Bender, K, Eickel, A, Malik, K U, Miller, D D, Desiderio, D M, Tigyi, G, Pott, L

“…Blood plasma and serum contain factors that activate inwardly rectifying GIRK1/GIRK4 K+ channels in atrial myocytes via one or more non-atropine-sensitive…”
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Proteolysis of the N-methyl-d-aspartate receptor by calpain in situ by Guttmann, Rodney P, Sokol, Set, Baker, Dana L, Simpkins, Kelly L, Dong, Yina, Lynch, David R

“…N-Methyl-D-aspartate (NMDA) receptors are calcium-permeable glutamate receptors that play putative roles in learning, memory, and excitotoxicity. NMDA…”
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Targeted Overexpression of the Sarcoplasmic Reticulum Ca2+-ATPase Increases Cardiac Contractility in Transgenic Mouse Hearts by Baker, Debra L, Hashimoto, Katsuji, Grupp, Ingrid L, Ji, Yong, Reed, Thomas, Loukianov, Evgenij, Grupp, Gunter, Bhagwhat, Ajit, Hoit, Brian, Walsh, Richard, Marban, Eduardo, Periasamy, Muthu

“…Cardiac hypertrophy and heart failure are known to be associated with a reduction in Ca pump levels of the sarcoplasmic reticulum (SR). To determine whether,…”
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Synthesis and pharmacological evaluation of second-generation phosphatidic acid derivatives as lysophosphatidic acid receptor ligands by Durgam, Gangadhar G., Tsukahara, Ryoko, Makarova, Natalia, Walker, Michelle D., Fujiwara, Yuko, Pigg, Kathryn R., Baker, Daniel L., Sardar, Vineet M., Parrill, Abby L., Tigyi, Gabor, Miller, Duane D.

“…Short-chain phosphatidic acid derivatives, dioctanoyl glycerol pyrophosphate (DGPP 8:0, 1) and phosphatidic acid 8:0 (PA 8:0, 2), were previously identified as…”
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Mice with transgenic overexpression of lipid phosphate phosphatase-1 display multiple organotypic deficits without alteration in circulating lysophosphatidate level by Yue, Junming, Yokoyama, Kazuaki, Balazs, Louisa, Baker, Daniel L., Smalley, David, Pilquil, Carlos, Brindley, David N., Tigyi, Gabor

“…Lipid phosphate phosphatase 1 (LPP-1) is presumed to regulate the balance between lipid phosphates and their dephosphorylated counterparts. The currently…”
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Specific proteolysis of the NR2 subunit at multiple sites by calpain by Guttmann, Rodney P., Baker, Dana L., Seifert, Kristen M., Cohen, Akiva S., Coulter, Douglas A., Lynch, David R.

“…The NMDA subtype of glutamate receptor plays an important role in the molecular mechanisms of learning, memory and excitotoxicity. NMDA receptors are highly…”
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