Search Results - "Baker, Brian"

TCR3d 2.0: expanding the T cell receptor structure database with new structures, tools and interactions by Lin, Valerie, Cheung, Melyssa, Gowthaman, Ragul, Eisenberg, Maya, Baker, Brian M, Pierce, Brian G

“…Recognition of antigens by T cell receptors (TCRs) is a key component of adaptive immunity. Understanding the structures of these TCR interactions provides…”
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T cell receptor therapeutics: immunological targeting of the intracellular cancer proteome by Klebanoff, Christopher A., Chandran, Smita S., Baker, Brian M., Quezada, Sergio A., Ribas, Antoni

“…The T cell receptor (TCR) complex is a naturally occurring antigen sensor that detects, amplifies and coordinates cellular immune responses to epitopes derived…”
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Genomic and bioinformatic profiling of mutational neoepitopes reveals new rules to predict anticancer immunogenicity by Duan, Fei, Duitama, Jorge, Al Seesi, Sahar, Ayres, Cory M, Corcelli, Steven A, Pawashe, Arpita P, Blanchard, Tatiana, McMahon, David, Sidney, John, Sette, Alessandro, Baker, Brian M, Mandoiu, Ion I, Srivastava, Pramod K

“…The mutational repertoire of cancers creates the neoepitopes that make cancers immunogenic. Here, we introduce two novel tools that identify, with relatively…”
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Engineering the T cell receptor for fun and profit: Uncovering complex biology, interrogating the immune system, and targeting disease by Rosenberg, Aaron M., Baker, Brian M.

“…T cell receptors (TCRs) orchestrate cellular immunity by recognizing peptide antigens bound and presented by major histocompatibility complex (MHC) proteins…”
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Peptide-dependent tuning of major histocompatibility complex motional properties and the consequences for cellular immunity by Ayres, Cory M, Baker, Brian M

“…T cell receptors (TCRs) and other receptors of the immune system recognize peptides presented by class I or class II major histocompatibility complex (MHC)…”
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The Energetic Landscape of Catch Bonds in TCR Interfaces by Ayres, Cory M, Corcelli, Steve A, Baker, Brian M

“…Recognition of peptide/MHC complexes by αβ TCRs has traditionally been viewed through the lens of conventional receptor-ligand theory. Recent work, however,…”
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An erythematous nodule on the nose by Boyd, Alan S., Baker, Brian L.

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Comparing Cyanophenyl and Pyridyl Ligands in the Formation of Porphyrin-Based Metal–Organic Coordination Networks by Baker Cortés, Brian D, Schmidt, Nico, Enache, Mihaela, Stöhr, Meike

“…In recent studies, porphyrin derivatives have been frequently used as building blocks for the fabrication of metal–organic coordination networks (MOCNs) on…”
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Chaperoning the dance of antigen presentation by Rosales, Tatiana J., Baker, Brian M.

“…Antigen loading onto class I major histocompatibility complex (MHC-I) proteins relies on chaperones and protein flexibility. Researchers now provide new…”
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Coverage-Dependent Structural Transformation of Cyano-Functionalized Porphyrin Networks on Au(111) via Addition of Cobalt Atoms by Baker Cortés, Brian D, Schmidt, Nico, Enache, Mihaela, Stöhr, Meike

“…The self-assembly process of a cobalt-porphyrin derivative (Co-TCNPP) containing cyanophenyl substituents at all four meso positions on Au(111) was studied by…”
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Characterization of Parylene-C degradation mechanisms: In vitro reactive accelerated aging model compared to multiyear in vivo implantation by Caldwell, Ryan, Street, Matthew G., Sharma, Rohit, Takmakov, Pavel, Baker, Brian, Rieth, Loren

“…Implantable neural microelectrodes are integral components of neuroprosthetic technologies and can transform treatments for many neural-mediated disorders…”
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High-throughput modeling and scoring of TCR-pMHC complexes to predict cross-reactive peptides by Borrman, Tyler, Pierce, Brian G, Vreven, Thom, Baker, Brian M, Weng, Zhiping

“…Abstract Motivation The binding of T-cell receptors (TCRs) to their target peptide MHC (pMHC) ligands initializes the cell-mediated immune response. In…”
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ART and lifelong IPT for health care workers with HIV: a priority for infection control by Baker, Brian J.

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SARS-CoV-2 spike does not interact with the T cell receptor or directly activate T cells by Gaglione, Stephanie A, Rosales, Tatiana J, Schmidt-Hong, Laura, Baker, Brian M, Birnbaum, Michael E

“…Suggested edit: SARS-CoV-2infection can induce multisystem inflammatory syndrome in children, which resembles superantigen-induced toxic shock syndrome. Recent…”
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LRRK2 binds to the Rab32 subfamily in a GTP-dependent manner via its armadillo domain by McGrath, Emma, Waschbüsch, Dieter, Baker, Brian M., Khan, Amir R.

“…LRRK2 is a multi-domain Ser/Thr kinase that is associated with inherited and sporadic cases of Parkinson's disease. Many mutations linked to disease are…”
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Structural dissimilarity from self drives neoepitope escape from immune tolerance by Devlin, Jason R., Alonso, Jesus A., Ayres, Cory M., Keller, Grant L. J., Bobisse, Sara, Vander Kooi, Craig W., Coukos, George, Gfeller, David, Harari, Alexandre, Baker, Brian M.

“…T-cell recognition of peptides incorporating nonsynonymous mutations, or neoepitopes, is a cornerstone of tumor immunity and forms the basis of new…”
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TCRs used in cancer gene therapy cross-react with MART-1/Melan-A tumor antigens via distinct mechanisms by Borbulevych, Oleg Y, Santhanagopolan, Sujatha M, Hossain, Moushumi, Baker, Brian M

“…T cells engineered to express TCRs specific for tumor Ags can drive cancer regression. The first TCRs used in cancer gene therapy, DMF4 and DMF5, recognize two…”
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The intersection of affinity and specificity in the development and optimization of T cell receptor based therapeutics by Riley, Timothy P., Baker, Brian M.

“…•T cell receptors are central to new immunological therapies.•TCRs mediate one of the most complex protein–protein interactions in biology.•Intricate selection…”
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Immunogenicity and therapeutic targeting of a public neoantigen derived from mutated PIK3CA by Chandran, Smita S., Ma, Jiaqi, Klatt, Martin G., Dündar, Friederike, Bandlamudi, Chaitanya, Razavi, Pedram, Wen, Hannah Y., Weigelt, Britta, Zumbo, Paul, Fu, Si Ning, Banks, Lauren B., Yi, Fei, Vercher, Enric, Etxeberria, Inaki, Bestman, Watchain D., Da Cruz Paula, Arnaud, Aricescu, Ilinca S., Drilon, Alexander, Betel, Doron, Scheinberg, David A., Baker, Brian M., Klebanoff, Christopher A.

“…Public neoantigens (NeoAgs) represent an elite class of shared cancer-specific epitopes derived from recurrently mutated driver genes. Here we describe a…”
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T cell receptor cross-reactivity expanded by dramatic peptide–MHC adaptability by Riley, Timothy P., Hellman, Lance M., Gee, Marvin H., Mendoza, Juan L., Alonso, Jesus A., Foley, Kendra C., Nishimura, Michael I., Vander Kooi, Craig W., Garcia, K. Christopher, Baker, Brian M.

“…T cell receptor cross-reactivity allows a fixed T cell repertoire to respond to a much larger universe of potential antigens. Recent work has emphasized the…”
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