Search Results - "Baker, Ann‐Marie"

Lineage tracing in human tissues by Gabbutt, Calum, Wright, Nicholas A, Baker, Ann‐Marie, Shibata, Darryl, Graham, Trevor A

“…The dynamical process of cell division that underpins homeostasis in the human body cannot be directly observed in vivo, but instead is measurable from the…”
Get full text

Histological 3D reconstruction and in vivo lineage tracing of the human endometrium by Tempest, Nicola, Jansen, Marnix, Baker, Ann‐Marie, Hill, Christopher J., Hale, Mike, Magee, Derek, Treanor, Darren, Wright, Nicholas A., Hapangama, Dharani K.

“…Regular menstrual shedding and repair of the endometrial functionalis is unique to humans and higher‐order primates. The current consensus postulates…”
Get full text

LOX-Mediated Collagen Crosslinking Is Responsible for Fibrosis-Enhanced Metastasis by COX, Thomas R, BIRD, Demelza, BAKER, Ann-Marie, BARKER, Holly E, HO, Melisa W-Y, LANG, Georgina, ERLER, Janine T

“…Tumor metastasis is a highly complex, dynamic, and inefficient process involving multiple steps, yet it accounts for more than 90% of cancer-related deaths…”
Get full text

Somatic POLE exonuclease domain mutations are early events in sporadic endometrial and colorectal carcinogenesis, determining driver mutational landscape, clonal neoantigen burden and immune response by Temko, Daniel, Van Gool, Inge C, Rayner, Emily, Glaire, Mark, Makino, Seiko, Brown, Matthew, Chegwidden, Laura, Palles, Claire, Depreeuw, Jeroen, Beggs, Andrew, Stathopoulou, Chaido, Mason, John, Baker, Ann‐Marie, Williams, Marc, Cerundolo, Vincenzo, Rei, Margarida, Taylor, Jenny C, Schuh, Anna, Ahmed, Ahmed, Amant, Frédéric, Lambrechts, Diether, Smit, Vincent THBM, Bosse, Tjalling, Graham, Trevor A, Church, David N, Tomlinson, Ian

“…Genomic instability, which is a hallmark of cancer, is generally thought to occur in the middle to late stages of tumourigenesis, following the acquisition of…”
Get full text

First passage time analysis of spatial mutation patterns reveals sub-clonal evolutionary dynamics in colorectal cancer by Haughey, Magnus J, Bassolas, Aleix, Sousa, Sandro, Baker, Ann-Marie, Graham, Trevor A, Nicosia, Vincenzo, Huang, Weini

“…The signature of early cancer dynamics on the spatial arrangement of tumour cells is poorly understood, and yet could encode information about how sub-clones…”
Get full text

Characterization of LGR5 stem cells in colorectal adenomas and carcinomas by Baker, Ann-Marie, Graham, Trevor A., Elia, George, Wright, Nicholas A., Rodriguez-Justo, Manuel

“…LGR5 is known to be a stem cell marker in the murine small intestine and colon, however the localization of LGR5 in human adenoma samples has not been examined…”
Get full text

Molecular characteristics of early‐onset pancreatic ductal adenocarcinoma by Debernardi, Silvana, Liszka, Lukasz, Ntala, Chara, Steiger, Katja, Esposito, Irene, Carlotti, Emanuela, Baker, Ann‐Marie, McDonald, Stuart, Graham, Trevor, Dmitrovic, Branko, Feakins, Roger M., Crnogorac‐Jurcevic, Tatjana

“…The median age of patients with pancreatic ductal adenocarcinoma (PDAC) at diagnosis is 71 years; however, around 10% present with early‐onset pancreatic…”
Get full text

Lysyl Oxidase Plays a Critical Role in Endothelial Cell Stimulation to Drive Tumor Angiogenesis by BAKER, Ann-Marie, BIRD, Demelza, WELTI, Jonathan C, GOURLAOUEN, Morgane, LANG, Georgina, MURRAY, Graeme I, REYNOLDS, Andrew R, COX, Thomas R, ERLER, Janine T

“…Identification of key molecules that drive angiogenesis is critical for the development of new modalities for the prevention of solid tumor progression. Using…”
Get full text

Quantification of Crypt and Stem Cell Evolution in the Normal and Neoplastic Human Colon by Baker, Ann-Marie, Cereser, Biancastella, Melton, Samuel, Fletcher, Alexander G., Rodriguez-Justo, Manuel, Tadrous, Paul J., Humphries, Adam, Elia, George, McDonald, Stuart A.C., Wright, Nicholas A., Simons, Benjamin D., Jansen, Marnix, Graham, Trevor A.

“…Human intestinal stem cell and crypt dynamics remain poorly characterized because transgenic lineage-tracing methods are impractical in humans. Here, we have…”
Get full text

Tumour Cell Heterogeneity [version 1; peer review: 5 approved] by Gay, Laura, Baker, Ann-Marie, Graham, Trevor A

“…The population of cells that make up a cancer are manifestly heterogeneous at the genetic, epigenetic, and phenotypic levels. In this mini-review, we summarise…”
Get full text

Immunosuppressive niche engineering at the onset of human colorectal cancer by Gatenbee, Chandler D., Baker, Ann-Marie, Schenck, Ryan O., Strobl, Maximilian, West, Jeffrey, Neves, Margarida P., Hasan, Sara Yakub, Lakatos, Eszter, Martinez, Pierre, Cross, William C. H., Jansen, Marnix, Rodriguez-Justo, Manuel, Whelan, Christopher J., Sottoriva, Andrea, Leedham, Simon, Robertson-Tessi, Mark, Graham, Trevor A., Anderson, Alexander R. A.

“…The evolutionary dynamics of tumor initiation remain undetermined, and the interplay between neoplastic cells and the immune system is hypothesized to be…”
Get full text

The Role of Lysyl Oxidase in SRC-Dependent Proliferation and Metastasis of Colorectal Cancer by BAKER, Ann-Marie, COX, Thomas R, BIRD, Demelza, LANG, Georgina, MURRAY, Graeme I, SUN, Xiao-Feng, SOUTHALL, Stacey M, WILSON, Jon R, ERLER, Janine T

“…Emerging evidence implicates lysyl oxidase (LOX), an extracellular matrix-modifying enzyme, in promoting metastasis of solid tumors. We investigated whether…”
Get full text

Virtual alignment of pathology image series for multi-gigapixel whole slide images by Gatenbee, Chandler D., Baker, Ann-Marie, Prabhakaran, Sandhya, Swinyard, Ottilie, Slebos, Robbert J. C., Mandal, Gunjan, Mulholland, Eoghan, Andor, Noemi, Marusyk, Andriy, Leedham, Simon, Conejo-Garcia, Jose R., Chung, Christine H., Robertson-Tessi, Mark, Graham, Trevor A., Anderson, Alexander R. A.

“…Interest in spatial omics is on the rise, but generation of highly multiplexed images remains challenging, due to cost, expertise, methodical constraints, and…”
Get full text

Robust RNA-based in situ mutation detection delineates colorectal cancer subclonal evolution by Baker, Ann-Marie, Huang, Weini, Wang, Xiao-Ming Mindy, Jansen, Marnix, Ma, Xiao-Jun, Kim, Jeffrey, Anderson, Courtney M., Wu, Xingyong, Pan, Liuliu, Su, Nan, Luo, Yuling, Domingo, Enric, Heide, Timon, Sottoriva, Andrea, Lewis, Annabelle, Beggs, Andrew D., Wright, Nicholas A., Rodriguez-Justo, Manuel, Park, Emily, Tomlinson, Ian, Graham, Trevor A.

“…Intra-tumor heterogeneity (ITH) is a major underlying cause of therapy resistance and disease recurrence, and is a read-out of tumor growth. Current genetic…”
Get full text

The miR-25-93-106b cluster regulates tumor metastasis and immune evasion via modulation of CXCL12 and PD-L1 by Cioffi, Michele, Trabulo, Sara M, Vallespinos, Mireia, Raj, Deepak, Kheir, Tony Bou, Lin, Meng-Lay, Begum, Julfa, Baker, Ann-Marie, Amgheib, Ala, Saif, Jaimy, Perez, Manuel, Soriano, Joaquim, Desco, Manuel, Gomez-Gaviro, Maria Victoria, Cusso, Lorena, Megias, Diego, Aicher, Alexandra, Heeschen, Christopher

“…The stromal microenvironment controls response to injury and inflammation, and is also an important determinant of cancer cell behavior. However, our…”
Get full text

PHLDA1 Mediates Drug Resistance in Receptor Tyrosine Kinase-Driven Cancer by Fearon, Abbie E., Carter, Edward P., Clayton, Natasha S., Wilkes, Edmund H., Baker, Ann-Marie, Kapitonova, Ekaterina, Bakhouche, Bakhouche A., Tanner, Yasmine, Wang, Jun, Gadaleta, Emanuela, Chelala, Claude, Moore, Kate M., Marshall, John F., Chupin, Juliette, Schmid, Peter, Jones, J. Louise, Lockley, Michelle, Cutillas, Pedro R., Grose, Richard P.

“…Development of resistance causes failure of drugs targeting receptor tyrosine kinase (RTK) networks and represents a critical challenge for precision medicine…”
Get full text

Distribution of the c-MYC gene product in colorectal neoplasia by Baker, Ann-Marie, Van Noorden, Susan, Rodriguez-Justo, Manuel, Cohen, Patrizia, Wright, Nicholas A, Lampert, Irvin A

“…Aims Recent attempts to study MYC distribution in human samples have been confounded by a lack of agreement in immunohistochemical staining between antibodies…”
Get full text

Pre-tumour clones, periodic selection and clonal interference in the origin and progression of gastrointestinal cancer: potential for biomarker development by Baker, Ann-Marie, Graham, Trevor A, Wright, Nicholas A

“…Classically, the risk of cancer progression in premalignant conditions of the gastrointestinal tract is assessed by examining the degree of histological…”
Get full text

A Pediatric Nursing Professional Development Team’s COVID-19 Response by Bleazard, Mark, Baker, Ann-Marie C., Crumpler, Cherie L., Dwyer, Erin C., Garver, Dana, Gossman, John W., Haut, Catherine M., Jenkins, Pamela S., Lietzke, Lisa M., Nusspickel, Kevin J., Watson, Norine

“…The role of pediatric hospitals in the COVID-19 pandemic changed quickly. The team of clinical nurse specialists and clinical nurse educators in a large…”
Get full text

Predicting Colorectal Cancer Occurrence in IBD by Yalchin, Mehmet, Baker, Ann-Marie, Graham, Trevor A, Hart, Ailsa

“…Patients with colonic inflammatory bowel disease (IBD) are at an increased risk of developing colorectal cancer (CRC), and are therefore enrolled into a…”
Get full text