Search Results - "Bakay, A."

Nerve Growth Factor Gene Therapy: Activation of Neuronal Responses in Alzheimer Disease by Tuszynski, Mark H, Yang, Jennifer H, Barba, David, U, Hoi-Sang, Bakay, Roy A E, Pay, Mary M, Masliah, Eliezer, Conner, James M, Kobalka, Peter, Roy, Subhojit, Nagahara, Alan H

“…Alzheimer disease (AD) is the most common neurodegenerative disorder and lacks effective disease-modifying therapies. In 2001, we initiated a clinical trial of…”
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Progression of intestinal permeability changes and alpha-synuclein expression in a mouse model of Parkinson's disease by Kelly, Leo P., Carvey, Paul M., Keshavarzian, Ali, Shannon, Kathleen M., Shaikh, Maliha, Bakay, Roy A. E., Kordower, Jeffrey H.

“…ABSTRACT Parkinson's disease (PD) is a multifocal degenerative disorder for which there is no cure. The majority of cases are sporadic with unknown etiology…”
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Delivery of neurturin by AAV2 (CERE-120)-mediated gene transfer provides structural and functional neuroprotection and neurorestoration in MPTP-treated monkeys by Kordower, Jeffrey H., Herzog, Christopher D., Dass, Biplob, Bakay, Roy A. E., Stansell III, James, Gasmi, Mehdi, Bartus, Raymond T.

“…Objective We tested the hypothesis that gene delivery of the trophic factor neurturin could preserve motor function and protect nigrostriatal circuitry in…”
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A phase1 study of stereotactic gene delivery of AAV2-NGF for Alzheimer's disease by Rafii, Michael S, Baumann, Tiffany L, Bakay, Roy A.E, Ostrove, Jeffrey M, Siffert, Joao, Fleisher, Adam S, Herzog, Christopher D, Barba, David, Pay, Mary, Salmon, David P, Chu, Yaping, Kordower, Jeffrey H, Bishop, Kathie, Keator, David, Potkin, Steven, Bartus, Raymond T

“…Abstract Background Nerve growth factor (NGF) is an endogenous neurotrophic-factor protein with the potential to restore function and to protect degenerating…”
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Safety and tolerability of intraputaminal delivery of CERE-120 (adeno-associated virus serotype 2–neurturin) to patients with idiopathic Parkinson's disease: an open-label, phase I trial by Marks, William J, MD, Ostrem, Jill L, MD, Verhagen, Leonard, MD, Starr, Philip A, MD, Larson, Paul S, MD, Bakay, Roy AE, MD, Taylor, Robin, MSN, Cahn-Weiner, Deborah A, PhD, Stoessl, A Jon, MD, Olanow, C Warren, MD, Bartus, Raymond T, PhD

“…Summary Background There is an urgent need for therapies that slow or reverse the progression of Parkinson's disease (PD). Neurotrophic factors can improve the…”
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Intrastriatal transplantation of microcarrier-bound human retinal pigment epithelial cells versus sham surgery in patients with advanced Parkinson's disease: a double-blind, randomised, controlled trial by Gross, Robert E, Dr, Watts, Raymond L, MD, Hauser, Robert A, MD, Bakay, Roy AE, MD, Reichmann, Heinz, MD, von Kummer, Rüdiger, MD, Ondo, William G, MD, Reissig, Elke, MD, Eisner, Wilhelm, MD, Steiner-Schulze, Heike, MS, Siedentop, Harald, PhD, Fichte, Klaus, PhD, Hong, Walter, MD, Cornfeldt, Michael, PhD, Beebe, Katherine, PhD, Sandbrink, Rupert, MD

“…Summary Background Human retinal pigment epithelial (RPE) cells produce levodopa and their transplantation into the striatum might improve continuity of…”
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Frameless deep brain stimulation using intraoperative O-arm technology: Clinical article by SMITH, Adam P, BAKAY, Roy A. E

“…Correct lead location in the desired target has been proven to be a strong influential factor for good clinical outcome in deep brain stimulation (DBS)…”
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Factors involved in long-term efficacy of deep brain stimulation of the thalamus for essential tremor by PILITSIS, Julie G, METMAN, Leo Verhagen, TOLEIKIS, John R, HUGHES, Lindsay E, SANI, Sepehr B, BAKAY, Roy A. E

“…Although nucleus ventralis intermedius stimulation has been shown to be safe and efficacious in the treatment of essential tremor, there is a subset of…”
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Long-Term Evaluation of Changes in Operative Technique and Hardware-Related Complications With Deep Brain Stimulation by Falowski, Steven M, Ooi, Yinn Cher, Bakay, Roy A E

“…Deep brain stimulation is the most frequent neurosurgical procedure for movement disorders. While this elective procedure carries a low-risk profile, it is not…”
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Deep brain stimulation for treatment of obesity in rats by SANI, Sepehr, JOBE, Kirk, SMITH, Adam, KORDOWER, Jeffrey H, BAKAY, Roy A. E

“…Given the success of deep brain stimulation (DBS) in a variety of applications (for example, Parkinson disease and essential tremor), other indications for…”
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Brain Blood‐flow Alterations Induced by Therapeutic Vagus Nerve Stimulation in Partial Epilepsy: II. Prolonged Effects at High and Low Levels of Stimulation by Henry, Thomas R., Bakay, Roy A. E., Pennell, Page B., Epstein, Charles M., Votaw, John R.

“…Purpose: To measure vagus nerve stimulation (VNS)‐induced cerebral blood flow (CBF) effects after prolonged VNS and to compare these effects with immediate VNS…”
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Composing domain-specific design environments by Ledeczi, A., Bakay, A., Maroti, M., Volgyesi, P., Nordstrom, G., Sprinkle, J., Karsai, G.

“…Domain-specific integrated development environments can help capture specifications in the form of domain models. These tools support the design process by…”
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Safety of magnetic resonance imaging of deep brain stimulator systems: a serial imaging and clinical retrospective study by CHHABRA, Vaninder, SUNG, Edward, MEWES, Klaus, BAKAY, Roy A. E, ABOSCH, Aviva, GROSS, Robert E

“…With the expanding indications and increasing number of patients undergoing deep brain stimulation (DBS), postoperative MR imaging is becoming even more…”
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Geology aspects, sedimentation environments and oil-and-gas bearing capacity of Vendian and Cambrian deposits of Lena-Tunguska basin by Korobova, Natalia I., Karnyushina, Evgeniya E., Shevchuk, Nadezhda S., Frolov, Sergei V., Bakay, Elena A., Akhmanov, Grigorii G.

“…At present time several dozen hydrocarbon fields are known in the Vendian-Cambrian complex of the Lena-Tunguska basin, which clearly does not exhaust its…”
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Randomized trial of pallidotomy versus medical therapy for Parkinson's disease by Vitek, Jerrold L., Bakay, Roy A. E., Freeman, Alan, Evatt, Marian, Green, Joanne, McDonald, William, Haber, Michael, Barnhart, Huiman, Wahlay, Natalie, Triche, Shirley, Mewes, Klaus, Chockkan, Vijay, Zhang, Jian-Yu, DeLong, Mahlon R.

“…Thirty‐six patients with Parkinson's disease (PD) were randomized to either medical therapy (N = 18) or unilateral GPi pallidotomy (N = 18). The primary…”
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Aortic Valve Cyclic Stretch Causes Increased Remodeling Activity and Enhanced Serotonin Receptor Responsiveness by Balachandran, Kartik, PhD, Bakay, Marina A., PhD, Connolly, Jeanne M., MS, Zhang, Xuemei, MS, Yoganathan, Ajit P., PhD, Levy, Robert J., MD

“…Background Increased serotonin (5-hydroxytryptamine [5HT]) receptor (5HTR) signaling has been associated with cardiac valvulopathy. Prior cell culture studies…”
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Effects of subthalamic nucleus stimulation and medication on resting and postural tremor in Parkinson's disease by Sturman, Molly M., Vaillancourt, David E., Metman, Leo Verhagen, Bakay, Roy A. E., Corcos, Daniel M.

“…Deep brain stimulation (DBS) of the subthalamic nucleus (STN) and antiparkinsonian medication have proved to be effective treatments for tremor in Parkinson's…”
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Stimulation-induced parkinsonism after posteroventral deep brain stimulation of the globus pallidus internus for craniocervical dystonia by Zauber, S Elizabeth, Watson, Nidhi, Comella, Cynthia L, Bakay, Roy A E, Metman, Leo Verhagen

“…The authors report on a patient with craniocervical dystonia who was treated with bilateral GPi stimulation, with excellent improvement in dystonia but at the…”
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Revision Surgery of Deep Brain Stimulation Leads by Falowski, Steven M, Bakay, Roy A E

“…Deep brain stimulation (DBS) is widely used for various movement disorders. DBS lead revisions are becoming more common as the indications and number of cases…”
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Restoration of neural output from a paralyzed patient by a direct brain connection by Kennedy, P R, Bakay, R A. E

“…PATIENTS with severe paralysis of limbs, face and vocal apparatus may be intelligent and aware and yet, tragically, unable to communicate. We describe a…”
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