Search Results - "Bakan, Courtney"

The PD-1/PD-L1 axis modulates the natural killer cell versus multiple myeloma effect: a therapeutic target for CT-011, a novel monoclonal anti–PD-1 antibody by Benson, Don M., Bakan, Courtney E., Mishra, Anjali, Hofmeister, Craig C., Efebera, Yvonne, Becknell, Brian, Baiocchi, Robert A., Zhang, Jianying, Yu, Jianhua, Smith, Megan K., Greenfield, Carli N., Porcu, Pierluigi, Devine, Steven M., Rotem-Yehudar, Rinat, Lozanski, Gerard, Byrd, John C., Caligiuri, Michael A.

“…T-cell expression of programmed death receptor-1 (PD-1) down-regulates the immune response against malignancy by interacting with cognate ligands (eg, PD-L1)…”
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Elotuzumab directly enhances NK cell cytotoxicity against myeloma via CS1 ligation: evidence for augmented NK cell function complementing ADCC by Collins, Shauna M., Bakan, Courtney E., Swartzel, Gina D., Hofmeister, Craig C., Efebera, Yvonne A., Kwon, Hakju, Starling, Gary C., Ciarlariello, David, Bhaskar, Shakthi, Briercheck, Edward L., Hughes, Tiffany, Yu, Jianhua, Rice, Audie, Benson, Don M.

“…Elotuzumab is a monoclonal antibody in development for multiple myeloma (MM) that targets CS1, a cell surface glycoprotein expressed on MM cells. In…”
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IPH2101, a novel anti-inhibitory KIR antibody, and lenalidomide combine to enhance the natural killer cell versus multiple myeloma effect by Benson, Don M., Bakan, Courtney E., Zhang, Shuhong, Collins, Shauna M., Liang, Jing, Srivastava, Shivani, Hofmeister, Craig C., Efebera, Yvonne, Andre, Pascale, Romagne, Francois, Bléry, Mathieu, Bonnafous, Cécile, Zhang, Jianying, Clever, David, Caligiuri, Michael A., Farag, Sherif S.

“…Multiple myeloma (MM) patients who receive killer cell Ig–like receptor (KIR) ligand–mismatched, T cell–depleted, allogeneic transplantation may have a reduced…”
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A small molecule, LLL12 inhibits constitutive STAT3 and IL-6-induced STAT3 signaling and exhibits potent growth suppressive activity in human multiple myeloma cells by Lin, Li, Benson Jr, Don M., DeAngelis, Stephanie, Bakan, Courtney E., Li, Pui-Kai, Li, Chenglong, Lin, Jiayuh

“…We characterized the effects of a newly developed signal transducers and activators of transcription 3 (STAT3) inhibitor, LLL12 in multiple myeloma (MM) cells…”
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Curcumin induces proapoptotic effects against human melanoma cells and modulates the cellular response to immunotherapeutic cytokines by Bill, Matthew A, Bakan, Courtney, Benson, Jr, Don M, Fuchs, James, Young, Gregory, Lesinski, Gregory B

“…Curcumin has potential as a chemopreventative and chemotherapeutic agent, but its interactions with clinically relevant cytokines are poorly characterized…”
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Recombinant interleukin‐2 in patients aged younger than 60 years with acute myeloid leukemia in first complete remission: Results from Cancer and Leukemia Group B 19808 by Kolitz, Jonathan E., George, Stephen L., Benson, Don M., Maharry, Kati, Marcucci, Guido, Vij, Ravi, Powell, Bayard L., Allen, Steven L., DeAngelo, Daniel J., Shea, Thomas C., Stock, Wendy, Bakan, Courtney E., Hars, Vera, Hoke, Eva, Bloomfield, Clara D., Caligiuri, Michael A., Larson, Richard A.

“…BACKGROUND Recombinant interleukin‐2 (rIL‐2) induces cellular cytotoxicity against leukemia blasts. Patients with acute myeloid leukemia (AML) in first…”
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The small molecule curcumin analog FLLL32 induces apoptosis in melanoma cells via STAT3 inhibition and retains the cellular response to cytokines with anti-tumor activity by Bill, Matthew A, Fuchs, James R, Li, Chenglong, Yui, Jennifer, Bakan, Courtney, Benson, Jr, Don M, Schwartz, Eric B, Abdelhamid, Dalia, Lin, Jiayuh, Hoyt, Dale G, Fossey, Stacey L, Young, Gregory S, Carson, 3rd, William E, Li, Pui-Kai, Lesinski, Gregory B

“…We characterized the biologic effects of a novel small molecule STAT3 pathway inhibitor that is derived from the natural product curcumin. We hypothesized this…”
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Expression of Concern: A small molecule, LLL12 inhibits constitutive STAT3 and IL‐6‐induced STAT3 signaling and exhibits potent growth suppressive activity in human multiple myeloma cells by Lin, Li, Benson, Don M., DeAngelis, Stephanie, Bakan, Courtney E., Li, Pui‐Kai, Li, Chenglong, Lin, Jiayuh

“…Abstract We characterized the effects of a newly developed signal transducers and activators of transcription 3 (STAT3) inhibitor, LLL12 in multiple myeloma…”
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Effects of induction with novel agents versus conventional chemotherapy on mobilization and autologous stem cell transplant outcomes in multiple myeloma by Benson, Don M., Panzner, Kathryn, Hamadani, Mehdi, Hofmeister, Craig C., Bakan, Courtney E., Smith, Megan K., Elder, Pat, Krugh, David, O'Donnell, Lynn, Devine, Steven M.

“…Multiple myeloma (MM) is the top indication for high-dose chemotherapy (HDC) with autologous stem cell transplantation (SCT), a strategy which improves…”
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A phase 1 trial of the anti-KIR antibody IPH2101 in patients with relapsed/refractory multiple myeloma by Benson, Don M., Hofmeister, Craig C., Padmanabhan, Swaminathan, Suvannasankha, Attaya, Jagannath, Sundar, Abonour, Rafat, Bakan, Courtney, Andre, Pascale, Efebera, Yvonne, Tiollier, Jérôme, Caligiuri, Michael A., Farag, Sherif S.

“…Natural killer (NK) cells elicit cytotoxicity against multiple myeloma (MM); however, MM cells express HLA class I molecules as ligands to NK cell inhibitory…”
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First Interim Results of a Phase I/II Study of Lenalidomide in Combination with Anti-PD-1 Monoclonal Antibody MDV9300 (CT-011) in Patients with Relapsed/Refractory Multiple Myeloma by Efebera, Yvonne A., Rosko, Ashley E, Hofmeister, Craig, Benner, Joe, Bakan, Courtney, Stamper, Kathleen, Lamb, Tammy, Hollie, Devine, Sell, Megan, Avigan, David, Benson, Don M

“…Introduction: Multiple myeloma (MM) is associated with profound and widespread disarray of both the adaptive and innate arms of the immune system including…”
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Curcumin Induces Pro-apoptotic Effects Against Human Melanoma Cells and Modulates The Cellular Response to Immunotherapeutic Cytokines by Bill, Matthew A., Bakan, Courtney, Benson, Don M., Fuchs, James, Young, Gregory, Lesinski, Gregory B.

“…Curcumin has potential as a chemopreventative and chemotherapeutic agent however its interactions with clinically relevant cytokines are poorly characterized…”
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IPH2101, a Novel Anti-Inhibitory KIR Monoclonal Antibody for Multiple Myeloma: Interm Phase 1 Trial Results and Correlative Biologic and Safety Data by Benson, Don M, Bakan, Courtney E, Padmanaban, Swaminathan, Abonour, Rafat, Suvannasankha, Attaya, Jagannath, Sundar, Chari, Ajai, Clever, David, Kalu, Chidimma, Collins, Shauna, Alghothani, Yousef, Hofmeister, Craig C., Efebera, Yvonne, Blanchet, Stephane, Caligiuri, Michael A., Farag, Sherif

“…Abstract 1966 A potent natural killer (NK) cell versus multiple myeloma (MM) effect has been reported in clinical observations and characterized…”
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Characterization of Early Natural Killer Cell Reconstitution Following Autologous Transplantation in Multiple Myeloma by Benson, Don, Bakan, Courtney E, Alghothani, Lana, Hofmeister, Craig C., Efebera, Yvonne A, Smith, Megan K, Greenfield, Carli N, Andre, Pascale, Squiban, Patrick, Romagne, Francois, Caligiuri, Michael A., Devine, Steven M

“…Abstract 4641 Despite the advent of novel therapies, multiple myeloma (MM) remains incurable and high-dose chemotherapy (HDC) with autologous stem cell…”
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Novel Monoclonal Antibody Enhances Natural Killer (NK) Cell Cytotoxicity against Multiple Myeloma (MM): Interim Phase 1 Trial Results by Benson, Don, Hofmeister, Craig C., Padmanabhan, Swaminathan, Abonour, Rafat, Suvannasankha, Attaya, Mita, Alain, Squiban, Patrick, Smith, Megan K, Bakan, Courtney E, Marzetto, Marc, Andre, Pascale, Tollier, Jerome, Caligiuri, Michael A., Farag, Sherif

“…Abstract 2880 Poster Board II-856 MM is increasing in incidence and remains incurable. .NK cells have modest killing activity against MM tumor cells in part…”
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IPH2101, a Novel Anti-Inhibitory KIR Monoclonal Antibody, and Lenalidomide Combine to Enhance the Natural Killer (NK) Cell Versus Multiple Myeloma (MM) Effect by Benson, Don, Bakan, Courtney E, Zhang, Shuhong, Alghothani, Lana, Liang, Jing, Hofmeister, Craig, Srivastava, Shivani, Smith, Megan K, Greenfield, Carli N, Andre, Pascale, Squiban, Patrick, Romagne, Francois, Caligiuri, Michael A., Farag, Sherif

“…Abstract 3870 Poster Board III-806 NK cell activity against tumor cells is regulated by a balance of inhibitory and activating signals mediated by receptors on…”
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