Search Results - "Bakalova, Rumiana"

Cellular redox imbalance on the crossroad between mitochondrial dysfunction, senescence, and proliferation by Bakalova, Rumiana, Aoki, Ichio, Zhelev, Zhivko, Higashi, Tatsuya

“…Recent studies demonstrate that redox imbalance of NAD+/NADH and NADP+/NADPH pairs due to impaired respiration may trigger two “hidden” metabolic pathways on…”
Get full text

Vitamin K: Redox-modulation, prevention of mitochondrial dysfunction and anticancer effect by Ivanova, Donika, Zhelev, Zhivko, Getsov, Plamen, Nikolova, Biliana, Aoki, Ichio, Higashi, Tatsuya, Bakalova, Rumiana

“…This review is directed to the redox-modulating properties and anticancer effect of vitamin K. The concept is focused on two aspects: (i) redox-cycle of…”
Get full text

Vitamin C versus Cancer: Ascorbic Acid Radical and Impairment of Mitochondrial Respiration? by Higashi, Tatsuya, Miller, Thomas, Zhelev, Zhivko, Bakalova, Rumiana, Aoki, Ichio

“…Vitamin C as a cancer therapy has a controversial history. Much of the controversy arises from the lack of predictive biomarkers for stratification of…”
Get full text

Overproduction of reactive oxygen species - obligatory or not for induction of apoptosis by anticancer drugs by Ivanova, Donika, Zhelev, Zhivko, Aoki, Ichio, Bakalova, Rumiana, Higashi, Tatsuya

“…Many studies demonstrate that conventional anticancer drugs elevate intracellular level of reactive oxygen species （ROS） and alter redox-homeostasis of cancer…”
Get full text

Electroporation, electrochemotherapy and electro-assisted drug delivery in cancer. A state-of-the-art review by Tsoneva, Iana, Semkova, Severina, Bakalova, Rumiana, Zhelev, Zhivko, Nuss, Philippe, Staneva, Galya, Nikolova, Biliana

“…This review focuses on electrochemotherapy that consists in the delivery of anti-cancer drugs using high-voltage electrical pulses. Technical issues, choice of…”
Get full text

Menadione/Ascorbate Induces Overproduction of Mitochondrial Superoxide and Impairs Mitochondrial Function in Cancer: Comparative Study on Cancer and Normal Cells of the Same Origin by Semkova, Severina, Zhelev, Zhivko, Miller, Thomas, Sugaya, Kimihiko, Aoki, Ichio, Higashi, Tatsuya, Bakalova, Rumiana

“…The menadione/ascorbate (M/A) combination has attracted attention due to the unusual ability of pro-vitamin/vitamin combination to kill cancer cells without…”
Get full text

Resveratrol Modulates the Redox-status and Cytotoxicity of Anticancer Drugs by Sensitizing Leukemic Lymphocytes and Protecting Normal Lymphocytes by Ivanova, Donika, Zhelev, Zhivko, Semkova, Severina, Aoki, Ichio, Bakalova, Rumiana

“…The study is directed to the effect of resveratrol on the redox-status and viability of leukemic and normal lymphocytes, as well as its ability to sensitize…”
Get full text

Corrigendum to “Cellular redox imbalance on the crossroad between mitochondrial dysfunction, senescence, and proliferation” [Redox Biol. 53 (2022) 102337] by Bakalova, Rumiana, Aoki, Ichio, Zhelev, Zhivko, Higashi, Tatsuya

Get full text

Tolerable treatment of glioblastoma with redox-cycling 'mitocans': a comparative study in vivo by Sumiyoshi, Akira, Shibata, Sayaka, Lazarova, Dessislava, Zhelev, Zhivko, Aoki, Ichio, Bakalova, Rumiana

“…The present study describes a pharmacological strategy for the treatment of glioblastoma by redoxcycling 'mitocans' such as quinone/ascorbate combination…”
Get full text

Quantum Sensors To Track Total Redox-Status and Oxidative Stress in Cells and Tissues Using Electron-Paramagnetic Resonance, Magnetic Resonance Imaging, and Optical Imaging by Lazarova, Dessislava, Semkova, Severina, Zlateva, Genoveva, Tatsuya, Higashi, Aoki, Ichio, Bakalova, Rumiana

“…Total redox capacity (TRC) and oxidative stress (OxiStress) of biological objects (such as cells, tissues, and body fluids) are some of the most frequently…”
Get full text

Redox-Cycling "Mitocans" as Effective New Developments in Anticancer Therapy by Bakalova, Rumiana, Lazarova, Dessislava, Sumiyoshi, Akira, Shibata, Sayaka, Zhelev, Zhivko, Nikolova, Biliana, Semkova, Severina, Vlaykova, Tatyana, Aoki, Ichio, Higashi, Tatsuya

“…Our study proposes a pharmacological strategy to target cancerous mitochondria via redox-cycling "mitocans" such as quinone/ascorbate (Q/A) redox-pairs, which…”
Get full text

Tissue Redox Activity as a Hallmark of Carcinogenesis: From Early to Terminal Stages of Cancer by BAKALOVA, Rumiana, ZHELEV, Zhivko, AOKI, Ichio, SAGA, Tsuneo

“…The study aimed to clarify the dynamics of tissue redox activity (TRA) in cancer progression and assess the importance of this parameter for therapeutic…”
Get full text

New potential biomarker for stratification of patients for pharmacological vitamin C in adjuvant settings of cancer therapy by Bakalova, Rumiana, Zhelev, Zhivko, Miller, Thomas, Aoki, Ichio, Higashi, Tatsuya

“…Our graphical review expands the analysis of cancer vulnerabilities for high dose vitamin C, based on several facts, illustrating the cytotoxic potential of…”
Get full text

Redox-related Molecular Mechanism of Sensitizing Colon Cancer Cells to Camptothecin Analog SN38 by Nikolova, Biliana, Semkova, Severina, Tsoneva, Iana, Stoyanova, Elena, Lefterov, Pavel, Lazarova, Dessislava, Zhelev, Zhivko, Aoki, Ichio, Higashi, Tatsuya, Bakalova, Rumiana

“…Background/Aim: The aim of this study was to elucidate the possibility of sensitizing colon cancer cells to the chemotherapeutic drug SN38 and investigate its…”
Get full text

Tissue redox activity as a sensing platform for imaging of cancer based on nitroxide redox cycle by Zhelev, Zhivko, Aoki, Ichio, Gadjeva, Veselina, Nikolova, Biliana, Bakalova, Rumiana, Saga, Tsuneo

“…Abstract The experience in free radical biology and medicine shows the crucial role of redox signalling in carcinogenesis. The cells and tissues of healthy…”
Get full text

Selective Targeting of Cancerous Mitochondria and Suppression of Tumor Growth Using Redox-Active Treatment Adjuvant by Higashi, Tatsuya, Aoki, Ichio, Shibata, Sayaka, Takeshima, Tsuguhide, Miller, Thomas, Zhelev, Zhivko, Ivanova, Donika, Semkova, Severina, Bakalova, Rumiana, Lazarova, Dessislava

“…Redox-active substances and their combinations, such as of quinone/ascorbate and in particular menadione/ascorbate (M/A; also named Apatone®), attract…”
Get full text

Imaging of Superoxide Generation in the Dopaminergic Area of the Brain in Parkinson’s Disease, Using Mito-TEMPO by Zhelev, Zhivko, Bakalova, Rumiana, Aoki, Ichio, Lazarova, Dessislava, Saga, Tsuneo

“…We report a new methodology for direct visualization of superoxide production in the dopaminergic area of the brain in Parkinson’s disease, based on the redox…”
Get full text

Single Quantum Dot-Micelles Coated with Silica Shell as Potentially Non-Cytotoxic Fluorescent Cell Tracers by Zhelev, Zhivko, Ohba, Hideki, Bakalova, Rumiana

“…The present study describes a stabilization of single quantum dot (QD) micelles by hydrophobic silica precursors and an extension of the silica layer to form a…”
Get full text

Quantum Dot-Based Western Blot Technology for Ultrasensitive Detection of Tracer Proteins by Bakalova, Rumiana, Zhelev, Zhivko, Ohba, Hideki, Baba, Yoshinobu

“…The present study describes two quantum dot-based Western blotting protocols for ultrasensitive detection of “tracer” proteins in cell lysates…”
Get full text

Inhibition of the Pentose-phosphate Pathway Selectively Sensitizes Leukemia Lymphocytes to Chemotherapeutics by ROS-independent Mechanism by Zhelev, Zhivko, Ivanova, Donika, Bakalova, Rumiana, Aoki, Ichio, Higashi, Tatsuya

“…The aim of the present study was to investigate: (i) the possibility of sensitizing leukemia lymphocytes to anticancer drugs by inhibiting pentose-phosphate…”
Get full text