Search Results - "Bajrami, Besnik"

Selective covalent targeting of GPX4 using masked nitrile-oxide electrophiles by Eaton, John K., Furst, Laura, Ruberto, Richard A., Moosmayer, Dieter, Hilpmann, André, Ryan, Matthew J., Zimmermann, Katja, Cai, Luke L., Niehues, Michael, Badock, Volker, Kramm, Anneke, Chen, Sixun, Hillig, Roman C., Clemons, Paul A., Gradl, Stefan, Montagnon, Claire, Lazarski, Kiel E., Christian, Sven, Bajrami, Besnik, Neuhaus, Roland, Eheim, Ashley L., Viswanathan, Vasanthi S., Schreiber, Stuart L.

“…We recently described glutathione peroxidase 4 (GPX4) as a promising target for killing therapy-resistant cancer cells via ferroptosis. The onset of therapy…”
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BI 456906: Discovery and preclinical pharmacology of a novel GCGR/GLP-1R dual agonist with robust anti-obesity efficacy by Zimmermann, Tina, Thomas, Leo, Baader-Pagler, Tamara, Haebel, Peter, Simon, Eric, Reindl, Wolfgang, Bajrami, Besnik, Rist, Wolfgang, Uphues, Ingo, Drucker, Daniel J., Klein, Holger, Santhanam, Rakesh, Hamprecht, Dieter, Neubauer, Heike, Augustin, Robert

“…Obesity and its associated comorbidities represent a global health challenge with a need for well-tolerated, effective, and mechanistically diverse…”
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A small-molecule allosteric inhibitor of Mycobacterium tuberculosis tryptophan synthase by Wellington, Samantha, Nag, Partha P, Michalska, Karolina, Johnston, Stephen E, Jedrzejczak, Robert P, Kaushik, Virendar K, Clatworthy, Anne E, Siddiqi, Noman, McCarren, Patrick, Bajrami, Besnik, Maltseva, Natalia I, Combs, Senya, Fisher, Stewart L, Joachimiak, Andrzej, Schreiber, Stuart L, Hung, Deborah T

“…High-throughput screening identifies an inhibitor of the interaction between α- and β-subunits of the Mycobacterium tuberculosis (Mtb) tryptophan synthase,…”
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Reactive Oxygen Species-Induced Actin Glutathionylation Controls Actin Dynamics in Neutrophils by Sakai, Jiro, Li, Jingyu, Subramanian, Kulandayan K., Mondal, Subhanjan, Bajrami, Besnik, Hattori, Hidenori, Jia, Yonghui, Dickinson, Bryan C., Zhong, Jia, Ye, Keqiang, Chang, Christopher J., Ho, Ye-Shih, Zhou, Jun, Luo, Hongbo R.

“…The regulation of actin dynamics is pivotal for cellular processes such as cell adhesion, migration, and phagocytosis and thus is crucial for neutrophils to…”
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G-CSF maintains controlled neutrophil mobilization during acute inflammation by negatively regulating CXCR2 signaling by Bajrami, Besnik, Zhu, Haiyan, Kwak, Hyun-Jeong, Mondal, Subhanjan, Hou, Qingming, Geng, Guangfeng, Karatepe, Kutay, Zhang, Yu C, Nombela-Arrieta, César, Park, Shin-Young, Loison, Fabien, Sakai, Jiro, Xu, Yuanfu, Silberstein, Leslie E, Luo, Hongbo R

“…Cytokine-induced neutrophil mobilization from the bone marrow to circulation is a critical event in acute inflammation, but how it is accurately controlled…”
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Allosteric inhibition of PPM1D serine/threonine phosphatase via an altered conformational state by Miller, Peter G., Sathappa, Murugappan, Moroco, Jamie A., Jiang, Wei, Qian, Yue, Iqbal, Sumaiya, Guo, Qi, Giacomelli, Andrew O., Shaw, Subrata, Vernier, Camille, Bajrami, Besnik, Yang, Xiaoping, Raffier, Cerise, Sperling, Adam S., Gibson, Christopher J., Kahn, Josephine, Jin, Cyrus, Ranaghan, Matthew, Caliman, Alisha, Brousseau, Merissa, Fischer, Eric S., Lintner, Robert, Piccioni, Federica, Campbell, Arthur J., Root, David E., Garvie, Colin W., Ebert, Benjamin L.

“…PPM1D encodes a serine/threonine phosphatase that regulates numerous pathways including the DNA damage response and p53. Activating mutations and amplification…”
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Reactive Oxygen Species-Producing Myeloid Cells Act as a Bone Marrow Niche for Sterile Inflammation-Induced Reactive Granulopoiesis by Zhu, Haiyan, Kwak, Hyun-Jeong, Liu, Peng, Bajrami, Besnik, Xu, Yuanfu, Park, Shin-Young, Nombela-Arrieta, Cesar, Mondal, Subhanjan, Kambara, Hiroto, Yu, Hongbo, Chai, Li, Silberstein, Leslie E, Cheng, Tao, Luo, Hongbo R

“…Both microbial infection and sterile inflammation augment bone marrow (BM) neutrophil production, but whether the induced accelerated granulopoiesis is…”
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Gasdermin D Exerts Anti-inflammatory Effects by Promoting Neutrophil Death by Kambara, Hiroto, Liu, Fei, Zhang, Xiaoyu, Liu, Peng, Bajrami, Besnik, Teng, Yan, Zhao, Li, Zhou, Shiyi, Yu, Hongbo, Zhou, Weidong, Silberstein, Leslie E., Cheng, Tao, Han, Mingzhe, Xu, Yuanfu, Luo, Hongbo R.

“…Gasdermin D (GSDMD) is considered a proinflammatory factor that mediates pyroptosis in macrophages to protect hosts from intracellular bacteria. Here, we…”
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Phosphoinositide lipid phosphatase SHIP1 and PTEN coordinate to regulate cell migration and adhesion by Mondal, Subhanjan, Subramanian, Kulandayan K, Sakai, Jiro, Bajrami, Besnik, Luo, Hongbo R

“…The second messenger phosphatidylinositol(3,4,5)P(3) (PtdIns(3,4,5)P(3)) is formed by stimulation of various receptors, including G protein-coupled receptors…”
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Positive Regulation of Interleukin-1β Bioactivity by Physiological ROS-Mediated Cysteine S-Glutathionylation by Zhang, Xue, Liu, Peng, Zhang, Christie, Chiewchengchol, Direkrit, Zhao, Fan, Yu, Hongbo, Li, Jingyu, Kambara, Hiroto, Luo, Kate Y., Venkataraman, Arvind, Zhou, Ziling, Zhou, Weidong, Zhu, Haiyan, Zhao, Li, Sakai, Jiro, Chen, Yuanyuan, Ho, Ye-Shih, Bajrami, Besnik, Xu, Bing, Silberstein, Leslie E., Cheng, Tao, Xu, Yuanfu, Ke, Yuehai, Luo, Hongbo R.

“…Reactive oxygen species (ROS)-induced cysteine S-glutathionylation is an important posttranslational modification (PTM) that controls a wide range of…”
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Cigarette smoke (CS) and nicotine delay neutrophil spontaneous death via suppressing production of diphosphoinositol pentakisphosphate by Xu, Yuanfu, Li, Hongmei, Bajrami, Besnik, Kwak, Hyunjeong, Cao, Shannan, Liu, Peng, Zhou, Jiaxi, Zhou, Yuan, Zhu, Haiyan, Ye, Keqiang, Luo, Hongbo R.

“…Diphosphoinositol pentakisphosphate (InsP7), a higher inositol phosphate containing energetic pyrophosphate bonds, is beginning to emerge as a key cellular…”
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Electrochemiluminescent Arrays for Cytochrome P450-Activated Genotoxicity Screening. DNA Damage from Benzo[a]pyrene Metabolites by Hvastkovs, Eli G, So, Minjeong, Krishnan, Sadagopan, Bajrami, Besnik, Tarun, Maricar, Jansson, Ingela, Schenkman, John B, Rusling, James F

“…Arrays suitable for genotoxicity screening are reported that generate metabolites from cytochrome P450 enzymes (CYPs) in thin-film spots. Array spots…”
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A Fast-Binding, Functionally Reversible, COX‑2 Radiotracer for CNS PET Imaging by Placzek, Michael S., Wilton, Daniel K., Weïwer, Michel, Manter, Mariah A., Reid, Sarah E., Meyer, Christopher J., Campbell, Arthur J., Bajrami, Besnik, Bigot, Antoine, Bricault, Sarah, Fayet, Agathe, Frouin, Arnaud, Gergits, Frederick, Gupta, Mehak, Jiang, Wei, Melanson, Michelle, Romano, Chiara D., Riley, Misha M., Wang, Jessica M., Wey, Hsiao-Ying, Wagner, Florence F., Stevens, Beth, Hooker, Jacob M.

“…Cyclooxygenase-2 (COX-2) is an enzyme that plays a pivotal role in peripheral inflammation and pain via the prostaglandin pathway. In the central nervous…”
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Conservation of the structure and function of bacterial tryptophan synthases by Michalska, Karolina, Gale, Jennifer, Joachimiak, Grazyna, Chang, Changsoo, Hatzos-Skintges, Catherine, Nocek, Boguslaw, Johnston, Stephen E, Bigelow, Lance, Bajrami, Besnik, Jedrzejczak, Robert P, Wellington, Samantha, Hung, Deborah T, Nag, Partha P, Fisher, Stewart L, Endres, Michael, Joachimiak, Andrzej

“…Tryptophan biosynthesis is one of the most characterized processes in bacteria, in which the enzymes from and serve as model systems. Tryptophan synthase…”
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Enzyme−DNA Biocolloids for DNA Adduct and Reactive Metabolite Detection by Chromatography−Mass Spectrometry by Bajrami, Besnik, Hvastkovs, Eli G, Jensen, Gary C, Schenkman, John B, Rusling, James F

“…Silica microbead bioreactors (0.5 μm diameter) coated with DNA and enzymes were fabricated to measure reactive metabolite and DNA−adduct formation rates…”
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2057-LB: Amino Acids Plasma Levels Do Not Correlate with Lean Mass Loss in Weight-Matched DIO Mice Treated with Survodutide or Semaglutide by Klepac-Bartl, Katarina, Pereira, Mafalda, Zimmermann, Tina, Rist, Wolfgang, Bajrami, Besnik, Kloeckener, Tim, Klein, Thomas

“…Concomitant with beneficial fat mass loss, anti-obesity therapies lead to detrimental lean mass loss. It is known that amino acids are essential for muscle…”
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mARC1 Is the Main Contributor to Metabolic Reduction of N‑Hydroxyurea by Klopp, Cathrin, Zhang, Xiaomei, Campbell, Morgan K., Kvaskoff, David, Struwe, Michel A., Warren, Curtis R., Bajrami, Besnik, Scheidig, Axel J., Jones, Amanda K., Clement, Bernd

“…N-Hydroxyurea has been known since the 1960s as an antiproliferative drug and is used both in oncology and for treatment of hematological disorders such as…”
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723-P: The Dual Glucagon and Glucagon-Like Peptide-1 Receptor (GCGR/GLP-1R) Agonist BI 4569Reduces Body Weight in Diet-Induced Obese Mice Based on Food Intake Reduction and an Increase in Energy Expenditure by ZIMMERMANN, TINA, THOMAS, LEO, BAADER-PAGLER, TAMARA, HAEBEL, PETER, NEUBAUER, HEIKE, SIMON, ERIC, REINDL, WOLFGANG, BAJRAMI, BESNIK, RIST, WOLFGANG, UPHUES, INGO, AUGUSTIN, ROBERT

“…BI 4569 is a synthetic peptide optimized to simultaneously engage the GCGR and GLP-1R. BI 4569 contains a fatty acid-based half-life extension that supports…”
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Discovery of a First-in-Class Inhibitor of the PRMT5–Substrate Adaptor Interaction by McKinney, David C, McMillan, Brian J, Ranaghan, Matthew J, Moroco, Jamie A, Brousseau, Merissa, Mullin-Bernstein, Zachary, O’Keefe, Meghan, McCarren, Patrick, Mesleh, Michael F, Mulvaney, Kathleen M, Robinson, Foxy, Singh, Ritu, Bajrami, Besnik, Wagner, Florence F, Hilgraf, Robert, Drysdale, Martin J, Campbell, Arthur J, Skepner, Adam, Timm, David E, Porter, Dale, Kaushik, Virendar K, Sellers, William R, Ianari, Alessandra

“…PRMT5 and its substrate adaptor proteins (SAPs), pICln and Riok1, are synthetic lethal dependencies in MTAP-deleted cancer cells. SAPs share a conserved PRMT5…”
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Myeloid Cell-Derived Reactive Oxygen Species Externally Regulate the Proliferation of Myeloid Progenitors in Emergency Granulopoiesis by Kwak, Hyun-Jeong, Liu, Peng, Bajrami, Besnik, Xu, Yuanfu, Park, Shin-Young, Nombela-Arrieta, César, Mondal, Subhanjan, Sun, Yan, Zhu, Haiyan, Chai, Li, Silberstein, Leslie E., Cheng, Tao, Luo, Hongbo R.

“…The cellular mechanisms controlling infection-induced emergency granulopoiesis are poorly defined. Here we found that reactive oxygen species (ROS)…”
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