Search Results - "Bajpai, Urmi"

Discovery and characterization of a novel LysinB from F2 sub-cluster mycobacteriophage RitSun by Arora, Ritu, Nadar, Kanika, Bajpai, Urmi

“…The escalating antibiotic resistance in mycobacterial species poses a significant threat globally, necessitating an urgent need to find alternative solutions…”
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Computational identification and characterization of antigenic properties of Rv3899c of Mycobacterium tuberculosis and its interaction with human leukocyte antigen (HLA) by Das, Ritam, Eniyan, Kandasamy, Bajpai, Urmi

“…A rise in drug-resistant tuberculosis (TB) cases demands continued efforts towards the discovery and development of drugs and vaccines. Secretory proteins of…”
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Functional characterization of the endolysins derived from mycobacteriophage PDRPxv by Eniyan, Kandasamy, Sinha, Avni, Ahmad, Shazeb, Bajpai, Urmi

“…Bacteriophage-derived endolysin enzymes play a critical role in disintegration of the host bacterial cell wall and hence have gained considerable attention as…”
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Beyond antibiotics: phage-encoded lysins against Gram-negative pathogens by Shah, Sanket, Das, Ritam, Chavan, Bhakti, Bajpai, Urmi, Hanif, Sarmad, Ahmed, Syed

“…Antibiotics remain the frontline agents for treating deadly bacterial pathogens. However, the indiscriminate use of these valuable agents has led to an…”
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Design and Synthesis of Various 5'-Deoxy-5'-(4-Substituted-1,2,3-Triazol-1-yl)-Uridine Analogues as Inhibitors of Mycobacterium tuberculosis Mur Ligases by Hervin, Vincent, Arora, Ritu, Rani, Jyoti, Ramchandran, Srinivasan, Bajpai, Urmi, Agrofoglio, Luigi A, Roy, Vincent

“…The synthesis of hitherto unknown 5'-deoxy-5'-(4-substituted-1,2,3-triazol-1-yl)-uridine and its evaluation, through an one-pot screening assay, against MurA-F…”
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Screening of compound library identifies novel inhibitors against the MurA enzyme of Escherichia coli by Raina, Diksha, Tiwari, Harshita, Sharma, Smriti, Deepika, Chinthakindi, Praveen Kumar, Nargotra, Amit, Sangwan, Payare L., Eniyan, Kandasamy, Bajpai, Urmi, Vishwakarma, Ram A., Khan, Farrah Gul, Saran, Saurabh, Khan, Inshad Ali

“…Bacterial cell has always been an attractive target for anti-infective drug discovery. MurA (UDP-N-acetylglucosamine enolpyruvyl transferase) enzyme of…”
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Functional characterization of a DNA-dependent AAA ATPase in a F-cluster mycobacteriophage by Das, Ritam, Bajpai, Urmi

“…•Characterization of a DNA-dependent AAA ATPase with putative DNA repair/maintenance/recombination role.•Sequence evaluation predicted AAA_24 and RecA/RadA…”
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Characterization and genome analysis of B1 sub-cluster mycobacteriophage PDRPxv by Sinha, Avni, Eniyan, Kandasamy, Manohar, Prasanth, Ramesh, Nachimuthu, Bajpai, Urmi

“…•A mycobacteriophage PDRPxv was isolated from soil sample using Mycobacterium smegmatis as host.•Mycobacteriophage PDRPxv belongs to the Siphoviridae…”
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Repurposing of FDA-approved drugs to target MurB and MurE enzymes in Mycobacterium tuberculosis by Rani, Jyoti, Silla, Yumnam, Borah, Kasmika, Ramachandran, Srinivasan, Bajpai, Urmi

“…Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb) is one amongst the top 10 causes of death worldwide. The growing rise in antibiotic resistance…”
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Crystal structure of UDP-N-acetylglucosamine-enolpyruvate reductase (MurB) from Mycobacterium tuberculosis by Eniyan, Kandasamy, Dharavath, Sudhaker, Vijayan, Ramachandran, Bajpai, Urmi, Gourinath, Samudrala

“…The biosynthesis of UDP-N-acetylmuramic acid (UDP-MurNAc) by reduction of UDP-N-acetylglucosamine-enolpyruvate (UDP-GlcNAc-EP) in an NADPH and FAD-dependent…”
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In silico prediction of natural compounds as potential multi-target inhibitors of structural proteins of SARS-CoV-2 by Rani, Jyoti, Bhargav, Anasuya, Khan, Faez Iqbal, Ramachandran, Srinivasan, Lai, Dakun, Bajpai, Urmi

“…The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a colossal loss to human health and lives and has deeply impacted socio-economic…”
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Identification of perturbed pathways rendering susceptibility to tuberculosis in type 2 diabetes mellitus patients using BioNSi simulation of integrated networks of implicated human genes by Rani, Jyoti, Bhargav, Anasuya, Seth, Surabhi, Datta, Malabika, Bajpai, Urmi, Ramachandran, Srinivasan

“…In type 2 diabetes mellitus (T2DM) patients, chronic hyperglycemia and inflammation underlie susceptibility to tuberculosis (TB) and result in poor TB control…”
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Mycobacteriophages: therapeutic approach for mycobacterial infections by Raman, Sunil Kumar, Siva Reddy, D.V., Jain, Vikas, Bajpai, Urmi, Misra, Amit, Singh, Amit Kumar

“…•Mycobacteriophages and phage-derived products offer a potential alternative for TB treatment.•Experience with phage therapy for NTM infections paves the way…”
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Development of a one-pot assay for screening and identification of Mur pathway inhibitors in Mycobacterium tuberculosis by Eniyan, Kandasamy, Kumar, Anuradha, Rayasam, Geetha Vani, Perdih, Andrej, Bajpai, Urmi

“…The cell wall of Mycobacterium tuberculosis (Mtb) consists of peptidoglycan, arabinogalactan and mycolic acids. The cytoplasmic steps in the peptidoglycan…”
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Alternative Treatment Strategies for Secondary Bacterial and Fungal Infections Associated with COVID-19 by Das, Ritam, Kotra, Komal, Singh, Pulkit, Loh, Belinda, Leptihn, Sebastian, Bajpai, Urmi

“…Antimicrobials are essential for combating infectious diseases. However, an increase in resistance to them is a major cause of concern. The empirical use of…”
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Insights into the genomic features and lifestyle of B1 subcluster mycobacteriophages by Das, Ritam, Arora, Ritu, Nadar, Kanika, Saroj, Saroj, Singh, Amit K., Patil, Shripad A., Raman, Sunil K., Misra, Amit, Bajpai, Urmi

“…Bacteriophages infecting Mycobacterium smegmatis mc2155 are numerous and, hence, are classified into clusters based on nucleotide sequence similarity…”
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P10 Phage-encoded lysins as promising antibacterials against uropathogenic Escherichia coli by Hanif, Sarmad, Das, Ritam, Chavan, Bhakti, Shah, Sanket, Bajpai, Urmi, Ahmed, Syed

“…Abstract Background Urinary tract infections (UTIs) represent a major public health issue. Uropathogenic Escherichia coli (UPEC) is a pathogen implicated in…”
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Correction to: Alternative Treatment Strategies for Secondary Bacterial and Fungal Infections Associated with COVID-19 by Das, Ritam, Kotra, Komal, Singh, Pulkit, Loh, Belinda, Leptihn, Sebastian, Bajpai, Urmi

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Isolation and characterization of bacteriophages from India, with lytic activity against Mycobacterium tuberculosis by Bajpai, Urmi, Mehta, Abhishek Kumar, Eniyan, Kandasamy, Sinha, Avni, Ray, Ankita, Virdi, Simran, Ahmad, Shazeb, Shah, Aridni, Arora, Deepanksha, Marwaha, Devyani, Chauhan, Gunjan, Saraswat, Prarthna, Bathla, Punita, Singh, Ruchi

“…Bacteriophages are being considered as a promising natural resource for the development of alternative strategies against mycobacterial diseases, especially in…”
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P26 Evaluating the antibacterial activity of recombinant phage-encoded lysin against drug-resistant uropathogenic Escherichia coli by Dhar, Sakshi, Nain, Sonia, Gupta, Vaishali, Gaharwar, Utkarsh, Chavan, Bhakti, Das, Ritam, Hanif, Sarmad, Bajpai, Urmi, Sikriwal, Deepa, Choudhary, Aasiya, Syeda, Safia, Shah, Sanket, Ahmed, Syed

“…Abstract Background Atrocious use of antibiotics has led to the emergence of MDR in uropathogenic Escherichia coli (UPEC) that poses a serious challenge in the…”
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