Search Results - "Bajbouj, Khuloud"

High-Dose Deferoxamine Treatment Disrupts Intracellular Iron Homeostasis, Reduces Growth, and Induces Apoptosis in Metastatic and Nonmetastatic Breast Cancer Cell Lines by Bajbouj, Khuloud, Shafarin, Jasmin, Hamad, Mawieh

“…Mounting evidence suggest that iron overload enhances cancer growth and metastasis; hence, iron chelation is being increasingly used as part of the treatment…”
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Histone Modification in NSCLC: Molecular Mechanisms and Therapeutic Targets by Bajbouj, Khuloud, Al-Ali, Abeer, Ramakrishnan, Rakhee K, Saber-Ayad, Maha, Hamid, Qutayba

“…Lung cancer is the leading cause of cancer mortality in both genders, with non-small cell lung cancer (NSCLC) accounting for about 85% of all lung cancers. At…”
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Estrogen-induced epigenetic silencing of FTH1 and TFRC genes reduces liver cancer cell growth and survival by Muhammad, Jibran Sualeh, Bajbouj, Khuloud, Shafarin, Jasmin, Hamad, Mawieh

“…Estrogen (E2) regulates hundreds of genes involved in cell metabolism and disrupts iron homoeostasis in various cell types. Herein, we addressed whether…”
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Copine 3 “CPNE3” is a novel regulator for insulin secretion and glucose uptake in pancreatic β-cells by El-Huneidi, Waseem, Anjum, Shabana, Mohammed, Abdul Khader, Unnikannan, Hema, Saeed, Rania, Bajbouj, Khuloud, Abu-Gharbieh, Eman, Taneera, Jalal

“…Copine 3 ( CPNE3 ) is a calcium-dependent phospholipid-binding protein that has been found to play an essential role in cancer progression and stages. However,…”
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Fisetin Deters Cell Proliferation, Induces Apoptosis, Alleviates Oxidative Stress and Inflammation in Human Cancer Cells, HeLa by Afroze, Nazia, Pramodh, Sreepoorna, Shafarin, Jasmin, Bajbouj, Khuloud, Hamad, Mawieh, Sundaram, Madhumitha Kedhari, Haque, Shafiul, Hussain, Arif

“…Fisetin, a flavonol profusely found in vegetables and fruits, exhibited a myriad of properties in preclinical studies to impede cancer growth. This study was…”
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Carnosol induces ROS-mediated beclin1-independent autophagy and apoptosis in triple negative breast cancer by Al Dhaheri, Yusra, Attoub, Samir, Ramadan, Gaber, Arafat, Kholoud, Bajbouj, Khuloud, Karuvantevida, Noushad, AbuQamar, Synan, Eid, Ali, Iratni, Rabah

“…In this study we investigated the in vitro and in vivo anticancer effect of carnosol, a naturally occurring polyphenol, in triple negative breast cancer. We…”
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The Coffee Diterpene, Kahweol, Ameliorates Pancreatic β-Cell Function in Streptozotocin (STZ)-Treated Rat INS-1 Cells through NF-kB and p-AKT/Bcl-2 Pathways by El-Huneidi, Waseem, Anjum, Shabana, Bajbouj, Khuloud, Abu-Gharbieh, Eman, Taneera, Jalal

“…Kahweol is a diterpene molecule found in coffee that exhibits a wide range of biological activity, including anti-inflammatory and anticancer properties…”
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Role of Matrix Metalloproteinases in Angiogenesis and Its Implications in Asthma by Bajbouj, Khuloud, Ramakrishnan, Rakhee K., Hamid, Qutayba

“…Asthma is a chronic airway disorder associated with aberrant inflammatory and remodeling responses. Angiogenesis and associated vascular remodeling are one of…”
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The Role of ATP-Binding Cassette Subfamily A in Colorectal Cancer Progression and Resistance by Alketbi, Latifa, Al-Ali, Abeer, Talaat, Iman M, Hamid, Qutayba, Bajbouj, Khuloud

“…Colorectal cancer (CRC) is one of the most common malignancies worldwide; it is the fourth leading cause of cancer-related deaths. CRC arises due to mutations…”
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The role of RNA-modifying proteins in renal cell carcinoma by Alhammadi, Muna A., Bajbouj, Khuloud, Talaat, Iman M., Hamoudi, Rifat

“…Gene expression is one of the most critical cellular processes. It is controlled by complex mechanisms at the genomic, epigenomic, transcriptomic, and…”
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Editorial: Emerging talents in pharmacology of anti-cancer drugs 2022 by Khan, Husain Yar, Bajbouj, Khuloud, Tolba, Mai F

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Defective autophagosome formation in p53-null colorectal cancer reinforces crocin-induced apoptosis by Amin, Amr, Bajbouj, Khuloud, Koch, Adrian, Gandesiri, Muktheshwar, Schneider-Stock, Regine

“…Crocin, a bioactive molecule of saffron, inhibited proliferation of both HCT116 wild-type and HCT116 p53(-/-) cell lines at a concentration of 10 mM. Flow…”
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Oncogenic Potential of Bisphenol A and Common Environmental Contaminants in Human Mammary Epithelial Cells by Nair, Vidhya A, Valo, Satu, Peltomäki, Päivi, Bajbouj, Khuloud, Abdel-Rahman, Wael M

“…There is an ample epidemiological evidence to support the role of environmental contaminants such as bisphenol A (BPA) in breast cancer development but the…”
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Nucleic acid sensor STING drives remodeling and its inhibition enhances steroid responsiveness in chronic obstructive pulmonary disease by Mdkhana, Bushra, Saheb Sharif-Askari, Narjes, Ramakrishnan, Rakhee K, Al-Sheakly, Baraa Khalid, Hafezi, Shirin, Saheb Sharif-Askari, Fatemeh, Bajbouj, Khuloud, Hamid, Qutayba, Halwani, Rabih

“…Chronic obstructive pulmonary disease (COPD) is progressive and irreversible chronic lung inflammatory disease. Cigarette smoke, the main cause of COPD, is…”
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Enhanced mitophagy in bronchial fibroblasts from severe asthmatic patients by Ramakrishnan, Rakhee K, Bajbouj, Khuloud, Hachim, Mahmood Y, Mogas, Andrea K, Mahboub, Bassam, Olivenstein, Ronald, Hamoudi, Rifat, Halwani, Rabih, Hamid, Qutayba

“…Sub-epithelial fibrosis is a characteristic feature of airway remodeling in asthma which correlates with disease severity. Current asthma medications are…”
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Estrogen-induced disruption of intracellular iron metabolism leads to oxidative stress, membrane damage, and cell cycle arrest in MCF-7 cells by Bajbouj, Khuloud, Shafarin, Jasmin, Abdalla, Maher Y, Ahmad, Iman M, Hamad, Mawieh

“…It is well established that several forms of cancer associate with significant iron overload. Recent studies have suggested that estrogen (E2) disrupts…”
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PRMT5 Selective Inhibitor Enhances Therapeutic Efficacy of Cisplatin in Lung Cancer Cells by Bajbouj, Khuloud, Ramakrishnan, Rakhee K., Saber-Ayad, Maha, Omar, Hany A., Saheb Sharif-Askari, Narjes, Shafarin, Jasmin, Elmoselhi, Adel B., Ihmaid, Ahmed, AlHaj Ali, Suhib, Alalool, Abdulla, Abdullah, Reem, Hamid, Qutayba

“…As a therapeutic approach, epigenetic modifiers have the potential to enhance the efficacy of chemotherapeutic agents. Protein arginine methyltransferase 5…”
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Carnosic Acid Induces Apoptosis and Inhibits Akt/mTOR Signaling in Human Gastric Cancer Cell Lines by El-Huneidi, Waseem, Bajbouj, Khuloud, Muhammad, Jibran Sualeh, Vinod, Arya, Shafarin, Jasmin, Khoder, Ghalia, Saleh, Mohamed A, Taneera, Jalal, Abu-Gharbieh, Eman

“…Gastric cancer is among the most common malignancies worldwide. Due to limited availability of therapeutic options, there is a constant need to find new…”
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Estrogen Signaling Induces Mitochondrial Dysfunction-Associated Autophagy and Senescence in Breast Cancer Cells by Bajbouj, Khuloud, Shafarin, Jasmin, Taneera, Jalal, Hamad, Mawieh

“…Previous work has shown that although estrogen (E2) disrupts cellular iron metabolism and induces oxidative stress in breast and ovarian cancer cells, it fails…”
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Iron Overload Induces Oxidative Stress, Cell Cycle Arrest and Apoptosis in Chondrocytes by Karim, Asima, Bajbouj, Khuloud, Shafarin, Jasmin, Qaisar, Rizwan, Hall, Andrew C, Hamad, Mawieh

“…Clinical and experimental evidence point to the presence of considerable links between arthropathy, osteoarthritis (OA) in particular, and iron overload…”
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