Radio-frequency plasma polymerized biodegradable carrier for in vivo release of cis-platinum

Radio-frequency plasma polymerized biodegradable carrier for in vivo release of cis-platinum

A low pressure plasma process based on plasma deposition has been used to develop a drug delivery strategy. In this study, a drug delivery system based on different layers of plasma co-polymerized Poly ε-caprolactone-Polyethylene glycol (PCL-PEG) co-polymers was deposited on biocompatible substrates...

Full description

Saved in:
Bibliographic Details
Published in:Oncotarget Vol. 7; no. 36; pp. 58121 - 58132
Main Authors: Bhatt, Sudhir, Valamanesh, Fatemeh, Pulpytel, Jerome, Lo Dico, Rea, Baiyukha, Aliby, Al-Dybiat, Iman, Pocard, Marc, Arefi-Khonsari, Farzaneh, Mirshahi, Massoud
Format: Journal Article
Language:English
Published: United States Impact journals 06-09-2016
Impact Journals LLC
Subjects:
Animals
Antineoplastic Agents - administration & dosage
Biodegradable Plastics - chemistry
Biodegradable Plastics - radiation effects
Cancer
Caproates - chemistry
Caproates - radiation effects
Cellophane - chemistry
Cellophane - radiation effects
Chemical Sciences
Cisplatin - administration & dosage
Delayed-Action Preparations - administration & dosage
Drug Carriers - chemistry
Drug Carriers - radiation effects
Drug Implants
Female
Lactones - chemistry
Lactones - radiation effects
Life Sciences
Liver - drug effects
Mice
Mice, Inbred BALB C
Microscopy, Electron, Scanning
Other
Polyethylene Glycols - chemistry
Polyethylene Glycols - radiation effects
Polymerization - radiation effects
Polymers - chemistry
Polymers - radiation effects
Radio Waves
Research Paper
Spectrum Analysis
plasma polymers
anti-cancer drug
targeted therapy
biodegradable coatings
in vivo drug delivery system
Plasma polymer
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A low pressure plasma process based on plasma deposition has been used to develop a drug delivery strategy. In this study, a drug delivery system based on different layers of plasma co-polymerized Poly ε-caprolactone-Polyethylene glycol (PCL-PEG) co-polymers was deposited on biocompatible substrates. Cis-platinum (118 μgm/cm2) was used as an anti-cancer drug and incorporated for local delivery of the chemotherapeutic agent. The co-polymer layers and their interaction with cancer cells were analyzed by scanning electron microscopy. Our study showed that the plasma-PCL-PEG coated cellophane membranes, in which the drug, was included did not modify the flexibility and appearance of the membranes. This system was actively investigated as an alternative method of controlling localized delivery of drug in vivo. The loading of the anti-cancer drug was investigated by UV-VIS spectroscopy and its release from plasma deposited implants against BALB/c mice liver tissues were analyzed through histological examination and apoptosis by TUNEL assay. The histological examination of liver tissues revealed that when the plasma-modified membranes encapsulated the cis-platinum, the Glisson's capsule and liver parenchyma were damaged. In all cases, inflammatory tissues and fibrosis cells were observed in contact zones between the implant and the liver parenchyma. In conclusion, low pressure plasma deposited uniform nano-layers of the co-polymers can be used for controlled release of the drug in vivo.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
PMCID: PMC5295417
ISSN:1949-2553
1949-2553
DOI:10.18632/oncotarget.10932