Search Results - "Baird, Sara"

Pumping the brakes: A noncanonical RNA-binding domain in FMRP stalls elongating ribosomes by Young-Baird, Sara K.

“…Loss of function of the RNA-binding protein FMRP causes fragile X syndrome, the most common inherited form of intellectual disability and autism spectrum…”
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Polyamine Control of Translation Elongation Regulates Start Site Selection on Antizyme Inhibitor mRNA via Ribosome Queuing by Ivanov, Ivaylo P., Shin, Byung-Sik, Loughran, Gary, Tzani, Ioanna, Young-Baird, Sara K., Cao, Chune, Atkins, John F., Dever, Thomas E.

“…Translation initiation is typically restricted to AUG codons, and scanning eukaryotic ribosomes inefficiently recognize near-cognate codons. We show that…”
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The Drosophila ribonucleoprotein Clueless is required for ribosome biogenesis in vivo by Sen, Aditya, Rodriguez-Martinez, Ambar, Young-Baird, Sara K., Cox, Rachel T.

“…As hubs of metabolism, mitochondria contribute critical processes to coordinate and optimize energy and intermediate metabolites. Drosophila Clueless (Clu) and…”
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Suppression of MEHMO Syndrome Mutation in eIF2 by Small Molecule ISRIB by Young-Baird, Sara K., Lourenço, Maíra Bertolessi, Elder, Megan K., Klann, Eric, Liebau, Stefan, Dever, Thomas E.

“…Dysregulation of cellular protein synthesis is linked to a variety of diseases. Mutations in EIF2S3, encoding the γ subunit of the heterotrimeric eukaryotic…”
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Novel pathogenic EIF2S3 missense variants causing clinically variable MEHMO syndrome with impaired eIF2γ translational function, and literature review by Kotzaeridou, Urania, Young‐Baird, Sara K., Suckow, Vanessa, Thornburg, Alexis G., Wagner, Matias, Harting, Inga, Christ, Stine, Strom, Tim, Dever, Thomas E., Kalscheuer, Vera M.

“…Rare pathogenic EIF2S3 missense and terminal deletion variants cause the X‐linked intellectual disability (ID) syndrome MEHMO, or a milder phenotype including…”
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Studies of a mosaic patient with DBA and chimeric mice reveal erythroid cell–extrinsic contributions to erythropoiesis by Doty, Raymond T., Fan, Xing, Young, David J., Liang, Jialiu, Singh, Komudi, Pakbaz, Zahra, Desmond, Ronan, Young-Baird, Sara K., Chandrasekharappa, Settara C., Donovan, Frank X., Phelps, Susan R., Winkler, Thomas, Dunbar, Cynthia E., Abkowitz, Janis L.

“…We follow a patient with Diamond-Blackfan anemia (DBA) mosaic for a pathogenic RPS19 haploinsufficiency mutation with persistent transfusion-dependent anemia…”
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Impaired EIF2S3 function associated with a novel phenotype of X-linked hypopituitarism with glucose dysregulation by Gregory, Louise C., Ferreira, Carolina B., Young-Baird, Sara K., Williams, Hywel J., Harakalova, Magdalena, van Haaften, Gijs, Rahman, Sofia A., Gaston-Massuet, Carles, Kelberman, Daniel, GOSgene, Qasim, Waseem, Camper, Sally A., Dever, Thomas E., Shah, Pratik, Robinson, Iain C.A.F., Dattani, Mehul T.

“…The heterotrimeric GTP-binding protein eIF2 forms a ternary complex with initiator methionyl-tRNA and recruits it to the 40S ribosomal subunit for start codon…”
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Dietary supplement use is common in older adult drivers: an analysis from the AAA LongROAD study by Moran, Ryan, Baird, Sara, DiGuiseppi, Carolyn G, Eby, David W, Hacker, Sarah, Isom, Chelsea, Jones, Vanya, Lee, Kelly C, Li, Guohua, Molnar, Lisa J, Patrick, Rudy, Strogatz, David, Hill, Linda

“…Dietary supplement (DS) use is common and increasing among older adults, though much data available on use frequencies are from surveys and performed…”
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Eltrombopag Improves Erythroid Differentiation in a Human Induced Pluripotent Stem Cell Model of Diamond Blackfan Anemia by Qanash, Husam, Li, Yongqin, Smith, Richard H, Linask, Kaari, Young-Baird, Sara, Hakami, Waleed, Keyvanfar, Keyvan, Choy, John S, Zou, Jizhong, Larochelle, Andre

“…Diamond Blackfan Anemia (DBA) is a congenital macrocytic anemia associated with ribosomal protein haploinsufficiency. Ribosomal dysfunction delays globin…”
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Age-related driving disorders: Screening in hospitals and outpatients settings by Baird, Sara, Hill, Linda, Rybar, Jill, Concha-Garcia, Susanna, Coimbra, Raul, Patrick, Kevin

“…Aim:  Older drivers are increasing in number and they often have health conditions that place them at high risk for motor vehicle crashes. The aims of this…”
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Gaps between Adolescent Risk Behaviors and Disclosure during Outpatient Visits by Hill, Linda L., Hovell, Melbourne, Blumberg, Elaine, Kelley, Norma, Baird, Sara, Sipan, Carol, Schmitz, Katharine, Friedman, Lawrence

“…Objective. The purpose of this study was to determine the gaps between disclosed high-risk behaviors in low-income, mainly Hispanic youth and the…”
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A survey of distracted driving and electronic device use among app-based and taxi drivers by Hill, Linda, Baird, Sara, Torres, Katy, Obrochta, Chelsea, Jain, Purva

“…The purpose of this study was to identify, characterize and compare attitudes, beliefs, behaviors and other factors related to electronic device (ED) use and…”
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MEHMO syndrome mutation EIF2S3-I259M impairs initiator Met-tRNAiMet binding to eukaryotic translation initiation factor eIF2 by Young-Baird, Sara K, Shin, Byung-Sik, Dever, Thomas E

“…Abstract The heterotrimeric eukaryotic translation initiation factor (eIF) 2 plays critical roles in delivering initiator Met-tRNAiMet to the 40S ribosomal…”
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‘Just Drive’: An Employee-Based Intervention to Reduce Distracted Driving by Hill, Linda, Rybar, Jill, Jahns, Jana, Lozano, Tanya, Baird, Sara

“…Distracted driving is a major danger on today’s roadways. Employers play a critical role in developing distracted driving policies and promoting a culture of…”
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American College of Preventive Medicine Position Statement: Reproductive Health Care by Plant, Amelia, Baird, Sara, Liu, Brandy A., Korin, Laura, Hill, Linda

“…The American College of Preventive Medicine (ACPM) recommends that state and federal governments, and non-governmental organizations ensure access to…”
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Eltrombopag Improves Erythroid Differentiation in a Human iPSC Model of Diamond Blackfan Anemia by Qanash, Husam, Linask, Kaari, Beers, Jeanette, Keyvanfar, Keyvan, Young-Baird, Sara, Hakami, Waleed, Smith, Richard H., Zou, Jizhong, Larochelle, Andre

“…Diamond Blackfan Anemia (DBA) is a congenital bone marrow (BM) failure syndrome primarily characterized by defective erythropoiesis. In most patients,…”
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Women's experiences with early pregnancy loss in the emergency room: A qualitative study by Baird, Sara, Gagnon, Monica D, deFiebre, Gabrielle, Briglia, Emily, Crowder, Rebecca, Prine, Linda

“…To understand the reasons why women present to the Emergency Room (ER) for Early Pregnancy Loss (EPL)-related care, how they perceive care and counseling…”
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Family planning services for incarcerated women: models for filling an unmet need by Sufrin, Carolyn, Baird, Sara, Clarke, Jennifer, Feldman, Elizabeth

“…Purpose Incarcerated women around the globe are predominantly of reproductive age. Most of these women have been pregnant before, and many want to be sexually…”
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Association of Depression and Antidepressant Use With Driving Behaviors in Older Adults: A LongROAD Study by Isom, Chelsea A., Baird, Sara, Betz, Marian E., DiGuiseppi, Carolyn G., Eby, David W., Li, Guohua, Lee, Kelly C, Molnar, Lisa J., Moran, Ryan, Strogatz, David, Hill, Linda

“…Older adults aged 70 and older who drive have higher crash death rates per mile driven compared to middle aged (35–54 years) adults who drive in the US. Prior…”
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Distracted Driving Behaviors and Beliefs among Older Adults by Hill, Linda, Baird, Sara, Engelberg, Jessa K., Larocca, Jacob, Alwahab, Uns, Chukwueke, Jasmine, Engler, Anne-Marie, Jahns, Jana, Rybar, Jill

“…Distracted driving, and especially cell phone use, is a prevalent contributor to crashes. Older drivers have an increased risk of committing safety errors…”
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