Search Results - "Baird, R D"

Results of the phase IIa RADICAL trial of the FGFR inhibitor AZD4547 in endocrine resistant breast cancer by Coombes, R. C., Badman, P. D., Lozano-Kuehne, J. P., Liu, X., Macpherson, I. R., Zubairi, I., Baird, R. D., Rosenfeld, N., Garcia-Corbacho, J., Cresti, N., Plummer, R., Armstrong, A., Allerton, R., Landers, D., Nicholas, H., McLellan, L., Lim, A., Mouliere, F., Pardo, O. E., Ferguson, V., Seckl, M. J.

“…We conducted a phase IIa, multi-centre, open label, single arm study (RADICAL; NCT01791985) of AZD4547 (a potent and selective inhibitor of Fibroblast Growth…”
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Author Correction: Results of the phase IIa RADICAL trial of the FGFR inhibitor AZD4547 in endocrine resistant breast cancer by Coombes, R. C., Badman, P. D., Lozano-Kuehne, J. P., Liu, X., Macpherson, I. R., Zubairi, I., Baird, R. D., Rosenfeld, N., Garcia-Corbacho, J., Cresti, N., Plummer, R., Armstrong, A., Allerton, R., Landers, D., Nicholas, H., McLellan, L., Lim, A., Mouliere, F., Pardo, O. E., Ferguson, V., Seckl, M. J.

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Drug resistance reversal—are we getting closer? by Baird, R.D, Kaye, S.B

“…Clinical drug resistance is a major barrier to overcome before chemotherapy can become curative for most patients presenting with metastatic cancer. Rational…”
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An extended phase Ib study of epertinib, an orally active reversible dual EGFR/HER2 tyrosine kinase inhibitor, in patients with solid tumours by Arkenau, H.-T., Italiano, A., Mak, G., Toulmonde, M., Baird, R.D., Garcia-Corbacho, J., Plummer, R., Flynn, M., Forster, M., Wilson, R.H., Tosi, D., Adenis, A., Donaldson, K., Posner, J., Kawabata, I., Arimura, A., Deva, S., Spicer, J.

“…Dose-escalation of epertinib (S-222611), a new potent oral EGFR/HER2 inhibitor, has established a recommended daily dose of 800 mg in patients with solid…”
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A phase I dose escalation and expansion trial of the next-generation oral SERD camizestrant in women with ER-positive, HER2-negative advanced breast cancer: SERENA-1 monotherapy results by Hamilton, E, Oliveira, M, Turner, N, García-Corbacho, J, Hernando, C, Ciruelos, E M, Kabos, P, Ruiz-Borrego, M, Armstrong, A, Patel, M R, Vaklavas, C, Twelves, C, Boni, V, Incorvati, J, Brier, T, Gibbons, L, Klinowska, T, Lindemann, J P O, Morrow, C J, Sykes, A, Baird, R D

“…SERENA-1 (NCT03616587) is a phase I, multi-part, open-label study of camizestrant in pre- and post-menopausal women with estrogen receptor-positive (ER+),…”
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Understanding Oestrogen Receptor Function in Breast Cancer and its Interaction with the Progesterone Receptor. New Preclinical Findings and their Clinical Implications by Baird, R.D, Carroll, J.S

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Post-operative endophthalmitis: the application of hazard analysis critical control points (HACCP) to an infection control problem by Baird, D.R., Henry, M., Liddell, K.G., Mitchell, C.M., Sneddon, J.G.

“…Hazard analysis critical control points (HACCP) is a quality assurance system widely used in the food industry to ensure safety. We adopted the HACCP approach…”
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An early review of 800 laparoscopic cholecystectomies at a university-affiliated community teaching hospital by Baird, D R, Wilson, J P, Mason, E M, Duncan, T D, Evans, J S, Luke, J P, Ruben, D M, Lucas, G W

“…Laparoscopic cholecystectomy (LC) was first performed at Georgia Baptist Medical Center (GBMC) in December 1989, subsequently becoming the treatment of choice…”
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A multicentre study of the in-vitro activity of cefotaxime, cefuroxime, ceftazidime, ofloxacin and ciprofloxacin against blood and urinary pathogens by Amyes, S G, Baird, D R, Crook, D W, Gillespie, S H, Howard, A J, Oppenhiem, B A, Pedler, S J, Paull, A, Tompkins, D S, Lawrie, S A

“…The in-vitro susceptibilities of aerobic bacteria isolated from 1804 blood and 4529 urine specimens collected at nine hospitals in the UK were examined. An…”
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The role of surgery in patients with advanced gynaecological cancers participating in phase I clinical trials by Vitfell-Pedersen, J, Yap, T A, Moreno, V, Baird, R D, Khan, A Z, Barton, D P J, Kaye, S B

“…While gynaecological cancer patients who participate in Phase I clinical trials are not routinely considered for elective surgery because of a short life…”
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An institutional review of the management of choledocholithiasis in 1616 patients undergoing laparoscopic cholecystectomy by Newman, 3rd, L, Newman, C, Baird, D R, Eubanks, S, Mason, E, Duncan, T, Lucas, G W

“…At Georgia Baptist Medical Center, 1616 patients underwent laparoscopic cholecystectomy between December 1989 and December 1992; and 103 perioperative…”
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Carcinoma-induced diffuse pulmonary haemorrhage by Baird, R D, Shee, C D

“…Diffuse pulmonary haemorrhage is an uncommon disorder usually associated with the vasculitides, collagen vascular diseases or anti-basement membrane antibody…”
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Carotid patch angioplasty: Immediate and long-term results by Rosenthal, David, Archie, Joseph P., Garcia-Rinaldi, Raul, Seagraves, M.Annette, Baird, David R., McKinsey, James F., Lamis, Pano A., Clark, Michael D., Erdoes, Luke S., Whitehead, Travis, Laszlo Pallos, L.

“…To determine the benefit of carotid patch angioplasty, a retrospective study of 1000 consecutive carotid endarterectomies was done. Based on the type of…”
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Systemic infection with Trichosporon capitatum in two patients with acute leukaemia by Baird, D R, Harris, M, Menon, R, Stoddart, R W

“…Trichosporon capitatum was isolated from the blood of two patients with acute leukaemia who were undergoing induction chemotherapy. Both patients died of their…”
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Fibrin degradation products in the cerebrospinal fluid of patients with pneumococcal meningitis by Cleland, P G, Macfarlane, J T, Baird, D R, Greenwood, B M

“…Raised levels of fibrin degradation products were found in the cerebrospinal fluid of nearly all of 35 patients with pneumococcal meningitis. The mean level…”
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Lyme disease with acute purulent meningitis by Bourke, S. J., Baird, A. G., Bone, F. J., Baird, D. R., Stevenson, R. D.

“…Cases of Lyme disease with neurological manifestations have recently been reported in Britain and were well documented in the original reports of this disease…”
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Outbreak of Legionnaires' disease in Glasgow Royal Infirmary: microbiological aspects by Timbury, M. C., Donaldson, J. R., McCartney, A. C., Fallon, R. J., Sleigh, J. D., Lyon, D., Orange, G. V., Baird, D. R., Winter, J., Wilson, T. S.

“…The bacteriological investigation of an outbreak of Legionnaires' disease in Glasgow Royal Infirmary affecting 16 patients is described. Most of the patients…”
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A phase I study evaluating the pharmacokinetics (PK) and pharmacodynamics (PD) of the oral pan-phosphoinositide-3 kinase (PI3K) inhibitor GDC-0941 by Baird, R. D., Kristeleit, R. S., Sarker, D., Olmos, D., Sandhu, S. K., Yan, Y., Koeppen, H., Levy, G. G., Jin, J., De Bono, J. S.

“…Abstract only…”
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Defining the risk of toxicity in phase I oncology trials of novel molecularly targeted agents: A single-center experience by Alam, S. M., Fehrmann, R. S., Olmos, D., Shah, K., Puglisi, M., Sarker, D., Brunetto, A., Postel-Vinay, S., Baird, R. D., Molife, L. R.

“…Abstract only…”
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Abstract OT1-01-07: PIONEER- Pre-operative wIndOw study of letrozole plus PR agonist megestrol acetate versus letrozole aloNE in post-menopausal patients with ER-positive breast cancer by Kumar, SS, Benson, J, McIntosh, S, King, P, Dougall, G, Kateb, A, Vallier, A-L, Jones, L, Qian, W, Provenzano, E, Caldas, C, Pantziarka, P, Carroll, J, Baird, RD

“…Abstract Background: Published preclinical findings provided new insights into the functional 'cross-talk' between the oestrogen receptor (ER) and the…”
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