Search Results - "Baird, Barbara A."

Lipid-based and protein-based interactions synergize transmembrane signaling stimulated by antigen clustering of IgE receptors by Bag, Nirmalya, Wagenknecht-Wiesner, Alice, Lee, Allan, Shi, Sophia M., Holowka, David A., Baird, Barbara A.

“…Antigen (Ag) crosslinking of immunoglobulin E–receptor (IgE-FcεRI) complexes in mast cells stimulates transmembrane (TM) signaling, requiring phosphorylation…”
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Correlation functions quantify super-resolution images and estimate apparent clustering due to over-counting by Veatch, Sarah L, Machta, Benjamin B, Shelby, Sarah A, Chiang, Ethan N, Holowka, David A, Baird, Barbara A

“…We present an analytical method using correlation functions to quantify clustering in super-resolution fluorescence localization images and electron microscopy…”
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Large-scale fluid/fluid phase separation of proteins and lipids in giant plasma membrane vesicles by Baumgart, Tobias, Hammond, Adam T, Sengupta, Prabuddha, Hess, Samuel T, Holowka, David A, Baird, Barbara A, Webb, Watt W

“…The membrane raft hypothesis postulates the existence of lipid bilayer membrane heterogeneities, or domains, supposed to be important for cellular function,…”
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Bright and Stable Core−Shell Fluorescent Silica Nanoparticles by Ow, Hooisweng, Larson, Daniel R, Srivastava, Mamta, Baird, Barbara A, Webb, Watt W, Wiesner, Ulrich

“…A class of highly fluorescent and photostable core−shell nanoparticles from a modified Stöber synthesis in the size range of 20−30 nm is described. These…”
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The Role of Membrane Affinity and Binding Modes in Alpha-Synuclein Regulation of Vesicle Release and Trafficking by Das, Tapojyoti, Ramezani, Meraj, Snead, David, Follmer, Cristian, Chung, Peter, Lee, Ka Yee, Holowka, David A, Baird, Barbara A, Eliezer, David

“…Alpha-synuclein is a presynaptic protein linked to Parkinson's disease with a poorly characterized physiological role in regulating the synaptic vesicle cycle…”
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Patterned Biofunctional Poly(acrylic acid) Brushes on Silicon Surfaces by Dong, Rong, Krishnan, Sitaraman, Baird, Barbara A, Lindau, Manfred, Ober, Christopher K

“…Protein patterning was carried out using a simple procedure based on photolithography wherein the protein was not subjected to UV irradiation and high…”
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Alpha synuclein modulates mitochondrial Ca2+ uptake from ER during cell stimulation and under stress conditions by Ramezani, Meraj, Wagenknecht-Wiesner, Alice, Wang, Tong, Holowka, David A., Eliezer, David, Baird, Barbara A.

“…Alpha synuclein (a-syn) is an intrinsically disordered protein prevalent in neurons, and aggregated forms are associated with synucleinopathies including…”
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Timescale Separation of Positive and Negative Signaling Creates History-Dependent Responses to IgE Receptor Stimulation by Harmon, Brooke, Chylek, Lily A., Liu, Yanli, Mitra, Eshan D., Mahajan, Avanika, Saada, Edwin A., Schudel, Benjamin R., Holowka, David A., Baird, Barbara A., Wilson, Bridget S., Hlavacek, William S., Singh, Anup K.

“…The high-affinity receptor for IgE expressed on the surface of mast cells and basophils interacts with antigens, via bound IgE antibody, and triggers secretion…”
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An Array of Planar Apertures for Near-Field Fluorescence Correlation Spectroscopy by Kelly, Christopher V., Baird, Barbara A., Craighead, Harold G.

“…We have developed a method of performing near-field fluorescence correlation spectroscopy via an array of planarized circular apertures of 50 nm diameter. This…”
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Focal adhesion proteins connect IgE receptors to the cytoskeleton as revealed by micropatterned ligand arrays by Torres, Alexis J, Vasudevan, Lavanya, Holowka, David, Baird, Barbara A

“…Patterned surfaces that present specific ligands in spatially defined arrays are used to examine structural linkages between clustered IgE receptors…”
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Temporally resolved interactions between antigen-stimulated IgE receptors and Lyn kinase on living cells by Larson, Daniel R, Gosse, Julie A, Holowka, David A, Baird, Barbara A, Webb, Watt W

“…Upon cross-linking by antigen, the high affinity receptor for immunoglobulin E (IgE), Fc[var epsilon]RI, is phosphorylated by the Src family tyrosine kinase…”
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An Interaction Library for the FcεRI Signaling Network by Chylek, Lily A, Holowka, David A, Baird, Barbara A, Hlavacek, William S

“…Antigen receptors play a central role in adaptive immune responses. Although the molecular networks associated with these receptors have been extensively…”
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Orthogonal Patterning of Multiple Biomolecules Using an Organic Fluorinated Resist and Imprint Lithography by Midthun, Kari M, Taylor, Priscilla G, Newby, Carol, Chatzichristidi, Margarita, Petrou, Panagiota S, Lee, Jin-Kyun, Kakabakos, Sotiris E, Baird, Barbara A, Ober, Christopher K

“…The ability to spatially deposit multiple biomolecules onto a single surface with high-resolution while retaining biomolecule stability and integrity is…”
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Preventing Nonspecific Adsorption on Polymer Brush Covered Gold Electrodes Using a Modified ATRP Initiator by Rastogi, Abhinav, Nad, Suddhasattwa, Tanaka, Manabu, Mota, Nicolas Da, Tague, Michele, Baird, Barbara A, Abruña, Héctor D, Ober, Christopher K

“…Biological systems have a tendency to adsorb nonspecifically onto a solid substrate, thus reducing the efficacy of the interface being used in biorecognition…”
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Transbilayer Coupling of Lipids in Cells Investigated by Imaging Fluorescence Correlation Spectroscopy by Bag, Nirmalya, London, Erwin, Holowka, David A, Baird, Barbara A

“…Plasma membranes host numerous receptors, sensors, and ion channels involved in cellular signaling. Phase separation within the plasma membrane has emerged as…”
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Lipid-driven interleaflet coupling of plasma membrane order regulates FcεRI signaling in mast cells by Yang, Gil-Suk, Wagenknecht-Wiesner, Alice, Yin, Boyu, Suresh, Pavana, London, Erwin, Baird, Barbara A, Bag, Nirmalya

“…Interleaflet coupling-the influence of one leaflet on the properties of the opposing leaflet-is a fundamental plasma membrane organizational principle. This…”
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Imaging FCS delineates subtle heterogeneity in plasma membranes of resting mast cells by Bag, Nirmalya, Holowka, David A, Baird, Barbara A

“…A myriad of transient, nanoscopic lipid- and protein-based interactions confer a steady-state organization of the plasma membrane in resting cells that is…”
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Bringing light to ER contacts and a new phase in organelle communication by Bag, Nirmalya, Ramezani, Meraj, Holowka, David A., Baird, Barbara A.

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Micropatterned Ligand Arrays to Investigate Spatial Regulation of Cellular Signaling Initiated by Clustered Fc Receptors by Mohr, Jordan D, Ramezani, Meraj, Holowka, David, Baird, Barbara A

“…Cell surface receptors that bind the Fc segment of antibodies to initiate signaling play fundamental roles in immune responses. Multiple, diverse Fc receptors…”
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A palmitoylation code controls PI4KIIIα complex formation and PI(4,5)P2 homeostasis at the plasma membrane by Batrouni, Alex G, Bag, Nirmalya, Phan, Henry T, Baird, Barbara A, Baskin, Jeremy M

“…Phosphatidylinositol 4-kinase IIIα (PI4KIIIα) is the major enzyme responsible for generating phosphatidylinositol (4)-phosphate [PI(4)P] at the plasma…”
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