Controlled delivery of taxol from microspheres composed of a blend of ethylene-vinyl acetate copolymer and poly ( d,l-lactic acid)

Controlled delivery of taxol from microspheres composed of a blend of ethylene-vinyl acetate copolymer and poly ( d,l-lactic acid)

‘Large’ (30–100 μm) and ‘small’ (10–30 μm) size range taxol-loaded microspheres composed of a blend of biodegradable poly ( d,l-lactic acid) (PLA) polymer and nondegradable ethylene-vinyl acetate (EVA) copolymer were prepared using the solvent evaporation method. Encapsulation efficiencies were betw...

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Bibliographic Details
Published in:Cancer letters Vol. 88; no. 1; pp. 73 - 79
Main Authors: Burt, Helen M., Jackson, John K., Bains, Sarvjeet K., Liggins, Richard T., Oktaba, Ann Marie C., Arsenault, A.Larry, Hunter, William L.
Format: Journal Article
Language:English
Published: Shannon Elsevier Ireland Ltd 06-01-1995
Elsevier
Subjects:
Angiogenesis inhibition
Animals
Biological and medical sciences
Chemoembolization
Chick Embryo
Delayed-Action Preparations - chemistry
General pharmacology
In Vitro Techniques
Lactates - chemistry
Lactic Acid
Medical sciences
Microscopy, Electron, Scanning
Microspheres
Neovascularization, Pathologic
Paclitaxel - administration & dosage
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Polymers
Polyvinyls - chemistry
Taxol
Microspheres
Angiogenesis inhibition
Taxol
Chemoembolization
Antineoplastic agent
Angiogenesis
EVA
Lactic acid polymer
Microsphere
Pharmaceutical technology
Controlled release form
Ester polymer
Inhibition
In vitro
Release
Mixture
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Summary:‘Large’ (30–100 μm) and ‘small’ (10–30 μm) size range taxol-loaded microspheres composed of a blend of biodegradable poly ( d,l-lactic acid) (PLA) polymer and nondegradable ethylene-vinyl acetate (EVA) copolymer were prepared using the solvent evaporation method. Encapsulation efficiencies were between 95–100% for taxol in 50:50 EVA:PLA blend microspheres. Between 10–13% of the total taxol content of the microspheres (0.6% w v taxol loading) was released in 50 days. Using the chick chorioallantoic membrane (CAM) model, the taxol microspheres released sufficient taxol to produce vascular regression and inhibition of angiogenesis. This taxol-loaded microsphere formulation may have potential for the targeted delivery of taxol to a tumor via arterial chemoembolization.
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ISSN:0304-3835
1872-7980
DOI:10.1016/0304-3835(94)03614-O