Search Results - "Baines, K J"

Obese asthmatics are characterized by altered adipose tissue macrophage activation by Periyalil, H. A., Wood, L. G., Wright, T. A., Karihaloo, C., Starkey, M. R., Miu, A. S., Baines, K. J., Hansbro, P. M., Gibson, P. G.

“…Summary Background Adipose tissue‐derived inflammation is linked to obesity‐related comorbidities. This study aimed to quantify and immuno‐phenotype adipose…”
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Different inflammatory phenotypes in adults and children with acute asthma by WANG, F, HE, X. Y, BAINES, K. J, GUNAWARDHANA, L. P, SIMPSON, J. L, LI, F, GIBSON, P. G

“…Inflammatory phenotypes are recognised in stable adult asthma, but are less well established in childhood and acute asthma. Additionally, Chlamydophila…”
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Activity and expression of histone acetylases and deacetylases in inflammatory phenotypes of asthma by Gunawardhana, L. P., Gibson, P. G., Simpson, J. L., Powell, H., Baines, K. J.

“…Summary Background Histone acetyltransferases (HATs) and histone deacetylases (HDACs) regulate gene expression, yet differences in the activity of these…”
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The role of biomarkers in the management of airways disease by Baines, K. J., Pavord, I. D., Gibson, P. G.

“…Chronic inflammatory airway diseases, including asthma and chronic obstructive pulmonary disease, are responsible for a large global disease burden. The…”
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Differential gene expression and cytokine production from neutrophils in asthma phenotypes by Baines, K. J, Simpson, J. L, Bowden, N. A, Scott, R. J, Gibson, P. G

“…Asthma is characterised into eosinophilic and non-eosinophilic phenotypes based on inflammatory cell patterns in airway secretions. Neutrophils are important…”
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Increased Peripheral Blood Pro-Inflammatory/Cytotoxic Lymphocytes in Children with Bronchiectasis by Hodge, G, Upham, J W, Chang, A B, Baines, K J, Yerkovich, S T, Pizzutto, S J, Hodge, S

“…Bronchiectasis (BE) in children is common in some communities including Indigenous children in Australia. Relatively little is known about the nature of…”
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Sputum ADAM8 expression is increased in severe asthma and COPD by Oreo, K. M., Gibson, P. G., Simpson, J. L., Wood, L. G., McDonald, V. M., Baines, K. J.

“…Summary Background Severe asthma and chronic obstructive pulmonary disease (COPD) are chronic inflammatory airway diseases in which the mechanisms are not…”
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Transcription Factors That Regulate Trophoblast Development and Function by Baines, K J, Renaud, S J

“…The placenta is a transient organ that plays a critical role in sustaining pregnancy and supporting fetal growth and nutrition. The placental epithelium is…”
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Airway responsiveness to mannitol in asthma is associated with chymase-positive mast cells and eosinophilic airway inflammation by Sverrild, A., Bergqvist, A., Baines, K. J., Porsbjerg, C., Andersson, C. K., Thomsen, S. F., Hoffmann, H. J., Gibson, P., Erjefält, J. S., Backer, V.

“…Summary Background Airway hyperresponsiveness (AHR) to inhaled mannitol is associated with indirect markers of mast cell activation and eosinophilic airway…”
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Advancing the management of obstructive airways diseases through translational research by Porsbjerg, C., Sverrild, A., Baines, K. J., Searles, A., Maltby, S., Foster, P. S., Brightling, C., Gibson, P. G.

“…Summary Obstructive airways diseases (OAD) represent a huge burden of illness world‐wide, and in spite of the development of effective therapies, significant…”
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Investigating the effects of arctic dietary intake on lung health by Baines, K J, Backer, V, Gibson, P G, Powell, H, Porsbjerg, C M

“…Background/Objective: Preservation of lung health requires understanding the modifiable risk factors of airflow limitation. This study investigates the…”
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Severity of Lung Function Impairment Drives Transcriptional Phenotypes of COPD and Relates to Immune and Metabolic Processes by Negewo, Netsanet A, Gibson, Peter G, Simpson, Jodie L, McDonald, Vanessa M, Baines, Katherine J

“…This study sought to characterize transcriptional phenotypes of COPD through unsupervised clustering of sputum gene expression profiles, and further…”
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Blood Neutrophils In COPD But Not Asthma Exhibit A Primed Phenotype With Downregulated CD62L Expression by Lokwani, Ravi, Wark, Peter Ab, Baines, Katherine J, Fricker, Michael, Barker, Daniel, Simpson, Jodie L

“…To characterize neutrophils in obstructive airway disease by measuring their surface adhesion molecules and oxidative burst along with characterizing them into…”
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Airway gene expression of IL-1 pathway mediators predicts exacerbation risk in obstructive airway disease by Baines, Katherine J, Fu, Juan-Juan, McDonald, Vanessa M, Gibson, Peter G

“…Exacerbations of asthma and COPD are a major cause of morbidity and mortality and are responsible for significant health care costs. This study further…”
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A Sputum 6 Gene Expression Signature Predicts Inflammatory Phenotypes and Future Exacerbations of COPD by Baines, Katherine J, Negewo, Netsanet A, Gibson, Peter G, Fu, Juan-Juan, Simpson, Jodie L, Wark, Peter A.B, Fricker, Michael, McDonald, Vanessa M

“…Background: The 6 gene expression signature (6GS) predicts inflammatory phenotype, exacerbation risk, and corticosteroid responsiveness in asthma. In COPD,…”
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Sex differences in innate and adaptive immunity impact fetal, placental, and maternal health by Baines, Kelly J., West, Rachel C.

“…The differences between males and females begin shortly after birth, continue throughout prenatal development, and eventually extend into childhood and adult…”
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Elevated expression of the NLRP3 inflammasome in neutrophilic asthma by SIMPSON, Jodie L, PHIPPS, Simon, BAINES, Katherine J, OREO, Kevin M, GUNAWARDHANA, Lakshitha, GIBSON, Peter G

“…Asthma is a heterogeneous inflammatory airways disorder where interleukin (IL)-1β is thought to be a key mediator, especially in the neutrophilic subtype of…”
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Neutrophil extracellular traps in obese asthma by Williams, E.J., Wood, L.G., Dowling, L.R., Stanton, S., Baines, K.J.

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A35 SEVERE ASTHMA: Galectin-3 Expression In Monocyte-Derived Macrophages From Severe Asthmatics by Erriah, M, Pabreja, K, Baines, K J, Fricker, M, Simpson, J L

“…The patients with asthma had a doctor's diagnosis with evidence of variable airflow obstruction and were prescribed high dose inhaled corticosteroids (ICS)…”
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Galectin-3 enhances monocyte-derived macrophage efferocytosis of apoptotic granulocytes in asthma by Erriah, Melanie, Pabreja, Kavita, Fricker, Michael, Baines, Katherine J, Donnelly, Louise E, Bylund, Johan, Karlsson, Anna, Simpson, Jodie L

“…Galectin-3 is a 32 kDa protein secreted by macrophages involved in processes such as cell activation, chemotaxis and phagocytosis. Galectin-3 has previously…”
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