Search Results - "Baines, Ian A."

Preclinical Strategy to Reduce Clinical Hepatotoxicity Using in Vitro Bioactivation Data for >200 Compounds by Sakatis, Melanie Z, Reese, Melinda J, Harrell, Andrew W, Taylor, Maxine A, Baines, Ian A, Chen, Liangfu, Bloomer, Jackie C, Yang, Eric Y, Ellens, Harma M, Ambroso, Jeffrey L, Lovatt, Cerys A, Ayrton, Andrew D, Clarke, Stephen E

“…Drug-induced liver injury is the most common cause of market withdrawal of pharmaceuticals, and thus, there is considerable need for better prediction models…”
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The Phosphorylation of Eukaryotic Initiation Factor eIF4E in Response to Phorbol Esters, Cell Stresses, and Cytokines Is Mediated by Distinct MAP Kinase Pathways by Wang, X, Flynn, A, Waskiewicz, A J, Webb, B L, Vries, R G, Baines, I A, Cooper, J A, Proud, C G

“…Initiation factor eIF4E binds to the 5′-cap of eukaryotic mRNAs and plays a key role in the mechanism and regulation of translation. It may be regulated…”
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Use of human tissue in ADME and safety profiling of development candidates by Coleman, Robert A, Bowen, Wayne P, Baines, Ian A, Woodrooffe, Amanda J, Brown, Anthony M

“…The clinical success of a compound is often curtailed because of inadequate safety, pharmacokinetics or efficacy. Human tissue can be used to identify the…”
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The Drosophila cell shape regulator c-Jun N-terminal kinase also functions as a stress-activated protein kinase by Botella, José A., Baines, Ian A., Williams, Daniel D., Goberdhan, Deborah C.I., Proud, Chris G., Wilson, Clive

“…Mammalian c-Jun N-terminal kinases (JNKs) are members of a group of stress-activated intracellular signalling molecules within the MAP kinase family. Molecular…”
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