Search Results - "Bain, Ryan M."

Organic Reactions in Microdroplets: Reaction Acceleration Revealed by Mass Spectrometry by Yan, Xin, Bain, Ryan M., Cooks, R. Graham

“…The striking finding that reaction acceleration occurs in confined‐volume solutions sets up an apparent conundrum: Microdroplets formed by spray ionization can…”
Get full text

“On‐Droplet” Chemistry: The Cycloaddition of Diethyl Azodicarboxylate and Quadricyclane by Bain, Ryan M., Sathyamoorthi, Shyam, Zare, Richard N.

“…Sharpless and co‐workers previously studied the [2σ+2σ+2π] cycloaddition of diethyl azodicarboxylate (DEAD) and quadricyclane and reported that the addition of…”
Get full text

Accelerated Chemical Reactions and Organic Synthesis in Leidenfrost Droplets by Bain, Ryan M., Pulliam, Christopher J., Thery, Fabien, Cooks, R. Graham

“…Leidenfrost levitated droplets can be used to accelerate chemical reactions in processes that appear similar to reaction acceleration in charged microdroplets…”
Get full text

Identification of diagnostic metabolic signatures in clear cell renal cell carcinoma using mass spectrometry imaging by Vijayalakshmi, Kanchustambham, Shankar, Vishnu, Bain, Ryan M., Nolley, Rosalie, Sonn, Geoffrey A., Kao, Chia‐Sui, Zhao, Hongjuan, Tibshirani, Robert, Zare, Richard N., Brooks, James D.

“…Clear cell renal cell carcinoma (ccRCC) is the most common and lethal subtype of kidney cancer. Intraoperative frozen section (IFS) analysis is used to confirm…”
Get full text

Mechanistic Analysis of the C–H Amination Reaction of Menthol by CuBr2 and Selectfluor by Sathyamoorthi, Shyam, Lai, Yin-Hung, Bain, Ryan M, Zare, Richard N

“…The mechanism of the Ritter-type C–H amination reaction of menthol with acetonitrile using CuBr2, Selectfluor, and Zn­(OTf)2, first disclosed by Baran and…”
Get full text

Accelerated Hantzsch electrospray synthesis with temporal control of reaction intermediates by Bain, Ryan M, Pulliam, Christopher J, Cooks, R Graham

“…Complex chemical reactions can occur in electrosprayed droplets on the millisecond time scale. The Hantzsch synthesis of 1,4-dihydropyridines was studied in…”
Get full text

A Low-Cost, Simplified Platform of Interchangeable, Ambient Ionization Sources for Rapid, Forensic Evidence Screening on Portable Mass Spectrometric Instrumentation by Fedick, Patrick, Fatigante, William, Lawton, Zachary, O’Leary, Adam, Hall, Seth, Bain, Ryan, Ayrton, Stephen, Ludwig, Joseph, Mulligan, Christopher

“…Portable mass spectrometers (MS) are becoming more prevalent due to improved instrumentation, commercialization, and the robustness of new ionization…”
Get full text

Characterization of 2‑Butanone Peroxide Oligomeric Profiles and Their Associated Gas-Phase and Solution-Phase Rearrangement Products by Electrospray Ionization Mass Spectrometry for Forensic Applications by Bain, Ryan M., Stutzman, John R., Pannuto, Julie, Kane, Meghan

“…2-Butanone peroxide (also known as methyl ethyl ketone peroxide, MEKP) has applications as a cross-linker in the chemical industry and is also encountered as a…”
Get full text

“On‐Droplet” Chemistry: The Cycloaddition of Diethyl Azodicarboxylate and Quadricyclane by Bain, Ryan M., Sathyamoorthi, Shyam, Zare, Richard N.

“…Sharpless and co‐workers previously studied the [2σ+2σ+2π] cycloaddition of diethyl azodicarboxylate (DEAD) and quadricyclane and reported that the addition of…”
Get full text

Online Bipolar Dual Spray for the Charge State Reduction and Characterization of Complex Synthetic Polymers by Stutzman, John R., Hutchins, Paul D., Bain, Ryan M.

“…Charge reduction mass spectrometry (CR/MS) hyphenated to liquid chromatography (LC) couples liquid-phase compound separation and mass spectral decompression to…”
Get full text

Microdroplets Accelerate Ring Opening of Epoxides by Lai, Yin-Hung, Sathyamoorthi, Shyam, Bain, Ryan M., Zare, Richard N.

“…The nucleophilic opening of an epoxide is a classic organic reaction that has widespread utility in both academic and industrial applications. We have studied…”
Get full text

Accelerated hydrazone formation in charged microdroplets by Bain, Ryan M., Pulliam, Christopher J., Ayrton, Stephen T., Bain, Kinsey, Cooks, R. Graham

“…Rationale Electrospray ionization‐mass spectrometry (ESI‐MS) is an emerging tool for reaction monitoring. It can be accompanied by reaction acceleration in…”
Get full text

Mass Spectrometry in the Home and Garden by Pulliam, Christopher J., Bain, Ryan M., Wiley, Joshua S., Ouyang, Zheng, Cooks, R. Graham

“…Identification of active components in a variety of chemical products used directly by consumers is described at both trace and bulk levels using mass…”
Get full text

Fischer Indole Synthesis in the Gas Phase, the Solution Phase, and at the Electrospray Droplet Interface by Bain, Ryan M., Ayrton, Stephen T., Cooks, R. Graham

“…Previous reports have shown that reactions occurring in the microdroplets formed during electrospray ionization can, under the right conditions, exhibit…”
Get full text

Chemical Synthesis Accelerated by Paper Spray: The Haloform Reaction by Bain, Ryan M, Pulliam, Christopher J, Raab, Shannon A, Cooks, R. Graham

“…In this laboratory, students perform a synthetic reaction in two ways: (i) by traditional bulk-phase reaction and (ii) in the course of reactive paper spray…”
Get full text

Mechanistic Analysis of the C-H Amination Reaction of Menthol by CuBr 2 and Selectfluor by Sathyamoorthi, Shyam, Lai, Yin-Hung, Bain, Ryan M, Zare, Richard N

“…The mechanism of the Ritter-type C-H amination reaction of menthol with acetonitrile using CuBr , Selectfluor®, and Zn(OTf) , first disclosed by Baran and…”
Get full text

Analysis of Residual Explosives by Swab Touch Spray Ionization Mass Spectrometry by Bain, Ryan M., Fedick, Patrick W., Dilger, Jonathan M., Cooks, R. Graham

“…Swab touch spray ionization mass spectrometry, an ambient ionization technique, has been applied to the analysis of six explosives from various surfaces…”
Get full text

Microdroplet Fusion Chemistry for Charge State Reduction of Synthetic Polymers via Bipolar Dual Spray with Anionic Reagents by Stutzman, John R., Bain, Ryan M., Hagenhoff, Sebastian, Woodward, William H., O’Brien, John P., Lesniak, Michael

“…Microdroplet fusion chemistry is an emerging area of analyte manipulation that utilizes the ion source region of a mass spectrometer to covalently derivatize…”
Get full text

Simultaneous Online Monitoring of Multiple Reactions Using a Miniature Mass Spectrometer by Pulliam, Christopher J, Bain, Ryan M, Osswald, Heather L, Snyder, Dalton T, Fedick, Patrick W, Ayrton, Stephen T, Flick, Tawnya G, Cooks, R. Graham

“…Advances in chemical sampling using miniature mass spectrometer technology are used to monitor slow reactions at a frequency of ca. 180 h–1 (on the Mini 12)…”
Get full text

Chiral Analysis by Tandem Mass Spectrometry Using the Kinetic Method, by Polarimetry, and by [Superscript 1]H NMR Spectroscopy by Fedick, Patrick W, Bain, Ryan M, Bain, Kinsey, Cooks, R. Graham

“…The goal of this laboratory exercise was for students to understand the concept of chirality and how enantiomeric excess (ee) is experimentally determined…”
Get full text