Search Results - "Bain, L J"

Effects of prolonged space flight on human skeletal muscle enzyme and substrate profiles by Fitts, R H, Colloton, P A, Trappe, S W, Costill, D L, Bain, J L W, Riley, D A

“…Our primary goal was to determine the effects of 6-mo flight on the International Space Station (ISS) on selected anaerobic and aerobic enzymes, and the…”
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The future is now: Model-based clinical trial design for Alzheimer's disease by Romero, K, Ito, K, Rogers, JA, Polhamus, D, Qiu, R, Stephenson, D, Mohs, R, Lalonde, R, Sinha, V, Wang, Y, Brown, D, Isaac, M, Vamvakas, S, Hemmings, R, Pani, L, Bain, LJ, Corrigan, B

“…Failures in trials for Alzheimer's disease (AD) may be attributable to inadequate dosing, population selection, drug inefficacy, or insufficient design…”
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Soleus muscle stability in wild hibernating black bears by Riley, D A, Van Dyke, J M, Vogel, V, Curry, B D, Bain, J L W, Schuett, R, Costill, D L, Trappe, T, Minchev, K, Trappe, S

“…Based on studies of fast skeletal muscles, hibernating black and brown bears resist skeletal muscle atrophy during months of reduced physical activity and not…”
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Effect of a 17 day spaceflight on contractile properties of human soleus muscle fibres by Widrick, J. J., Knuth, S. T., Norenberg, K. M., Romatowski, J. G., Bain, J. L., Riley, D. A., Karhanek, M., Trappe, S. W., Trappe, T. A., Costill, D. L., Fitts, R. H.

“…Soleus biopsies were obtained from four male astronauts 45 days before and within 2 h after a 17 day spaceflight. For all astronauts, single chemically skinned…”
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Characterization of MOAT-C and MOAT-D, new members of the MRP/cMOAT subfamily of transporter proteins by BELINSKY, M. G, BAIN, L. J, BALSARA, B. B, TESTA, J. R, KRUH, G. D

“…Multidrug resistance-associated protein (MRP) and canalicular multispecific organic anion transporter (cMOAT) are transporter proteins that pump organic anions…”
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Prolonged space flight‐induced alterations in the structure and function of human skeletal muscle fibres by Fitts, R. H., Trappe, S. W., Costill, D. L., Gallagher, P. M., Creer, A. C., Colloton, P. A., Peters, J. R., Romatowski, J. G., Bain, J. L., Riley, D. A.

“…The primary goal of this study was to determine the effects of prolonged space flight (∼180 days) on the structure and function of slow and fast fibres in…”
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Skeletal muscle fiber atrophy: altered thin filament density changes slow fiber force and shortening velocity by Riley, D A, Bain, J L W, Romatowski, J G, Fitts, R H

“…Single skinned fibers from soleus and adductor longus (AL) muscles of weight-bearing control rats and rats after 14-day hindlimb suspension unloading (HSU)…”
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Comparative gender differences in local and systemic concentrations of pro-inflammatory cytokines in rats with experimental periodontitis by Bain, J. L., Lester, S. R., Henry, W. D., Bishop, C. M., Turnage, A. A., Naftel, J. P., Johnson, R. B.

“…Background and Objective:  There have been few studies of gender differences in response to periodontitis. Thus, we compared gender‐specific differences in…”
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Functional properties of slow and fast gastrocnemius muscle fibers after a 17-day spaceflight by Widrick, J. J, Romatowski, J. G, Norenberg, K. M, Knuth, S. T, Bain, J. L. W, Riley, D. A, Trappe, S. W, Trappe, T. A, Costill, D. L, Fitts, R. H

“…1  Department of Biology, Marquette University, Milwaukee 53201; 2  Department of Cellular Biology and Anatomy, Medical College of Wisconsin, Milwaukee,…”
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Relationship between the gingival sulcus depth and interleukin-1 isoform concentrations within the adjacent gingival tissue by Lester, S. R., Bain, J. L., Serio, F. G., Johnson, R. B.

“…Background and Objective:  While there is substantial information concerning the concentrations of interleukin‐1 isoforms within gingival crevicular fluid,…”
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Effect of 17 days of bed rest on peak isometric force and unloaded shortening velocity of human soleus fibers by Widrick, J. J., Romatowski, J. G., Bain, J. L., Trappe, S. W., Trappe, T. A., Thompson, J. L., Costill, D. L., Riley, D. A., Fitts, R. H.

“…The purpose of this study was to examine the effect of prolonged bed rest (BR) on the peak isometric force (P0) and unloaded shortening velocity (V0) of single…”
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Passive stretch inhibits central corelike lesion formation in the soleus muscles of hindlimb-suspended unloaded rats by Baewer, D. V, Hoffman, M, Romatowski, J. G, Bain, J. L. W, Fitts, R. H, Riley, D. A

“…1 Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee 53226; and 2 Department of Biology, Marquette University,…”
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Interaction of structurally diverse pesticides with the human MDR1 gene product P-glycoprotein by Bain, L.J. (North Carolina State University, Raleigh, NC.), LeBlanc, G.A

“…P-glycoprotein (P-gp) is a 170-kDa membrane-bound glycoprotein shown to efflux a wide variety of chemicals, such as chemotherapeutic agents and carcinogens…”
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Rat hindlimb unloading: soleus histochemistry, ultrastructure, and electromyography by Riley, D A, Slocum, G R, Bain, J L, Sedlak, F R, Sowa, T E, Mellender, J W

“…Soleus muscle atrophy was induced by hindlimb unloading of male Sprague-Dawley rats (305 +/- 15 g) for 4, 7, and 10-14 days. Controls (291 +/- 14 g) were…”
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Disproportionate loss of thin filaments in human soleus muscle after 17-day bed rest by Riley, Danny A., Bain, James L.W., Thompson, Joyce L., Fitts, Robert H., Widrick, Jeffrey J., Trappe, Scott W., Trappe, Todd A., Costill, David L.

“…Previously we reported that, after 17-day bed rest unloading of 8 humans, soleus slow fibers atrophied and exhibited increased velocity of shortening without…”
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Advancing Alzheimer’s Disease Treatment: Lessons from CTAD 2018 by Vellas, B., Bain, L. J., Touchon, J., Aisen, P. S.

“…The 2018 Clinical Trials on Alzheimer’s Disease (CTAD) conference showcased recent successes and failures in trials of Alzheimer’s disease treatments. More…”
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Altered expression of sulfotransferases, glucuronosyltransferases and mrp transporters in FVB mrp1- - mice by Bain, L. J., Feldman, R. A.

“…1. Genetically altered mice increasingly are being used in toxicology and pharmaceutical development. As such, knowledge of the compensatory activity of…”
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In-flight and postflight changes in skeletal muscles of SLS-1 and SLS-2 spaceflown rats by Riley, D A, Ellis, S, Slocum, G R, Sedlak, F R, Bain, J L, Krippendorf, B B, Lehman, C T, Macias, M Y, Thompson, J L, Vijayan, K, De Bruin, J A

“…Spacelab Life Sciences-1 and -2 provided skeletal muscles from rats dissected in flight for the first time and 2 h to 14 days postflight. The muscles permitted…”
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Muscle sarcomere lesions and thrombosis after spaceflight and suspension unloading by Riley, D A, Ellis, S, Giometti, C S, Hoh, J F, Ilyina-Kakueva, E I, Oganov, V S, Slocum, G R, Bain, J L, Sedlak, F R

“…Spaceflight (flight) and tail suspension-hindlimb unloading (unloaded) produced significant decreases in fiber cross-sectional areas of the adductor longus…”
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Trivalent chromium alters gene expression in the mummichog (Fundulus heteroclitus) by Maples, Nikki L., Bain, L Isa J.

“…Mummichogs (Fundulus heteroclitus) were used as a model fish species to study the effects of trivalent chromium exposure. To ascertain chromium's effects, we…”
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