Search Results - "Bain, Jenny"

The selectivity of protein kinase inhibitors: a further update by Bain, Jenny, Plater, Lorna, Elliott, Matt, Shpiro, Natalia, Hastie, C James, McLauchlan, Hilary, Klevernic, Iva, Arthur, J Simon C, Alessi, Dario R, Cohen, Philip

“…The specificities of 65 compounds reported to be relatively specific inhibitors of protein kinases have been profiled against a panel of 70-80 protein kinases…”
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The specificities of protein kinase inhibitors: an update by Bain, Jenny, McLauchlan, Hilary, Elliott, Matthew, Cohen, Philip

“…We have previously examined the specificities of 28 commercially available compounds, reported to be relatively selective inhibitors of particular…”
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The selectivity of inhibitors of protein kinase CK2: an update by Pagano, Mario A, Bain, Jenny, Kazimierczuk, Zygmunt, Sarno, Stefania, Ruzzene, Maria, Di Maira, Giovanni, Elliott, Matthew, Orzeszko, Andrzej, Cozza, Giorgio, Meggio, Flavio, Pinna, Lorenzo A

“…CK2 (casein kinase 2) is a very pleiotropic serine/threonine protein kinase whose abnormally high constitutive activity has often been correlated to…”
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BIRB796 Inhibits All p38 MAPK Isoforms in Vitro and in Vivo by Kuma, Yvonne, Sabio, Guadalupe, Bain, Jenny, Shpiro, Natalia, Márquez, Rodolfo, Cuenda, Ana

“…The compound BIRB796 inhibits the stress-activated protein kinases p38α and p38β and is undergoing clinical trials for the treatment of inflammatory diseases…”
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Quinalizarin as a potent, selective and cell-permeable inhibitor of protein kinase CK2 by Cozza, Giorgio, Mazzorana, Marco, Papinutto, Elena, Bain, Jenny, Elliott, Matthew, di Maira, Giovanni, Gianoncelli, Alessandra, Pagano, Mario A, Sarno, Stefania, Ruzzene, Maria, Battistutta, Roberto, Meggio, Flavio, Moro, Stefano, Zagotto, Giuseppe, Pinna, Lorenzo A

“…Emodin (1,3,8-trihydroxy-6-methyl-anthraquinone) is a moderately potent and poorly selective inhibitor of protein kinase CK2, one of the most pleiotropic…”
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D4476, a cell-permeant inhibitor of CK1, suppresses the site-specific phosphorylation and nuclear exclusion of FOXO1a by Rena, Graham, Bain, Jenny, Elliott, Matthew, Cohen, Philip

“…The protein kinase CK1 phosphorylates serine residues that are located close to another phosphoserine in the consensus pSer‐Xaa‐Xaa‐Ser. This specificity…”
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Synthesis, Kinase Inhibitory Potencies, and in Vitro Antiproliferative Evaluation of New Pim Kinase Inhibitors by Akué-Gédu, Rufine, Rossignol, Emilie, Azzaro, Stéphane, Knapp, Stefan, Filippakopoulos, Panagis, Bullock, Alex N, Bain, Jenny, Cohen, Philip, Prudhomme, Michelle, Anizon, Fabrice, Moreau, Pascale

“…Members of the Pim kinase family have been identified as promising targets for the development of antitumor agents. After a screening of pyrrolo[2,3-a]- and…”
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Exploitation of KESTREL to identify NDRG family members as physiological substrates for SGK1 and GSK3 by Murray, James T, Campbell, David G, Morrice, Nicholas, Auld, Gillian C, Shpiro, Natalia, Marquez, Rodolpho, Peggie, Mark, Bain, Jenny, Bloomberg, Graham B, Grahammer, Florian, Lang, Florian, Wulff, Peer, Kuhl, Dietmar, Cohen, Philip

“…We detected a protein in rabbit skeletal muscle extracts that was phosphorylated rapidly by SGK1 (serum- and glucocorticoid-induced kinase 1), but not by…”
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Optimization of Protein Kinase CK2 Inhibitors Derived from 4,5,6,7-Tetrabromobenzimidazole by Pagano, Mario A, Andrzejewska, Mariola, Ruzzene, Maria, Sarno, Stefania, Cesaro, Luca, Bain, Jenny, Elliott, Matthew, Meggio, Flavio, Kazimierczuk, Zygmunt, Pinna, Lorenzo A

“…Casein kinase 2 (CK2) is a ubiquitous, essential, and highly pleiotropic protein kinase whose abnormally high constitutive activity is suspected to underlie…”
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Tetrabromocinnamic Acid (TBCA) and Related Compounds Represent a New Class of Specific Protein Kinase CK2 Inhibitors by Pagano, Mario A., Poletto, Giorgia, Di Maira, Giovanni, Cozza, Giorgio, Ruzzene, Maria, Sarno, Stefania, Bain, Jenny, Elliott, Matthew, Moro, Stefano, Zagotto, Giuseppe, Meggio, Flavio, Pinna, Lorenzo A.

“…Abnormally high constitutive activity of protein kinase CK2, levels of which are elevated in a variety of tumours, is suspected to underlie its pathogenic…”
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Biochemical and three-dimensional-structural study of the specific inhibition of protein kinase CK2 by [5-oxo-5,6-dihydroindolo-(1,2-a)quinazolin-7-yl]acetic acid (IQA) by Sarno, Stefania, de Moliner, Erika, Ruzzene, Maria, Pagano, Mario A, Battistutta, Roberto, Bain, Jenny, Fabbro, Doriano, Schoepfer, Joseph, Elliott, Matthew, Furet, Pascal, Meggio, Flavio, Zanotti, Giuseppe, Pinna, Lorenzo A

“…IQA [[5-oxo-5,6-dihydro-indolo(1,2-a)quinazolin-7-yl]acetic acid] is a novel ATP/GTP site-directed inhibitor of CK2 ('casein kinase 2'), a pleiotropic and…”
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Inhibition of Protein Kinase CK2 by Condensed Polyphenolic Derivatives. An in Vitro and in Vivo Study by Meggio, Flavio, Pagano, Mario A, Moro, Stefano, Zagotto, Giuseppe, Ruzzene, Maria, Sarno, Stefania, Cozza, Giorgio, Bain, Jenny, Elliott, Matthew, Deana, Arianna Donella, Brunati, Anna Maria, Pinna, Lorenzo A

“…ATP site-directed inhibitors that can target individual kinases are powerful tools for use in signal transduction research, all the more so in the case of a…”
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Inhibition of RET tyrosine kinase by SU5416 by Mologni, Luca, Sala, Elisa, Cazzaniga, Sara, Rostagno, Roberta, Kuoni, Thomas, Puttini, Miriam, Bain, Jenny, Cleris, Loredana, Redaelli, Sara, Riva, Barbara, Formelli, Franca, Scapozza, Leonardo, Gambacorti-Passerini, Carlo

“…Thyroid neoplasia is frequently associated with rearranged during transfection (RET) proto-oncogene mutations that cause hyperactivation of RET kinase…”
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New 2-bromomethyl-8-substituted-benzo[ c]chromen-6-ones. Synthesis and biological properties by Garino, Cédrik, Bihel, Frédéric, Pietrancosta, Nicolas, Laras, Younes, Quéléver, Gilles, Woo, Irene, Klein, Peter, Bain, Jenny, Boucher, Jean-Luc, Kraus, Jean-Louis

“…[Display omitted] New 2-bromomethyl-8-substituted-benzo[ c]chromen-6-ones have been synthesized and their bioactive properties have been evaluated on different…”
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Calmodulin-dependent protein kinase kinase-β is an alternative upstream kinase for AMP-activated protein kinase by Hawley, Simon A., Pan, David A., Mustard, Kirsty J., Ross, Louise, Bain, Jenny, Edelman, Arthur M., Frenguelli, Bruno G., Hardie, D. Grahame

“…The AMP-activated protein kinase (AMPK) is a critical regulator of energy balance at both the cellular and whole-body levels. Two upstream kinases have been…”
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The Mnks Are Novel Components in the Control of TNFα Biosynthesis and Phosphorylate and Regulate hnRNP A1 by Buxadé, Maria, Parra, Josep L., Rousseau, Simon, Shpiro, Natalia, Marquez, Rodolfo, Morrice, Nick, Bain, Jenny, Espel, Enric, Proud, Christopher G.

“…Posttranscriptional regulatory mechanisms control TNFα expression through AU-rich elements in the 3′UTR of its mRNA. This is mediated through Erk and p38 MAP…”
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Synthesis, Pim kinase inhibitory potencies and in vitro antiproliferative activities of diversely substituted pyrrolo[2,3-a]carbazoles by Akué-Gédu, Rufine, Nauton, Lionel, Théry, Vincent, Bain, Jenny, Cohen, Philip, Anizon, Fabrice, Moreau, Pascale

“…The synthesis of new pyrrolo[2,3-a]carbazole derivatives diversely substituted at the C-6 to C-9 positions is described. These compounds were tested for their…”
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Solenopsin, the alkaloidal component of the fire ant (Solenopsis invicta), is a naturally occurring inhibitor of phosphatidylinositol-3-kinase signaling and angiogenesis by Arbiser, Jack L., Kau, Tweeny, Konar, Martha, Narra, Krishna, Ramchandran, Ramani, Summers, Scott A., Vlahos, Chris J., Ye, Keqiang, Perry, Betsy N., Matter, William, Fischl, Anthony, Cook, James, Silver, Pamela A., Bain, Jenny, Cohen, Philip, Whitmire, David, Furness, Scott, Govindarajan, Baskaran, Bowen, J. Phillip

“…Phosphatidylinositol-3-kinase (PI3K), and its downstream effector Akt, or protein kinase Bα (PKBα), play a major regulatory role in control of apoptosis,…”
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The Mnks Are Novel Components in the Control of TNF[alpha] Biosynthesis and Phosphorylate and Regulate hnRNP A1 by Buxadé, Maria, Parra, Josep L, Rousseau, Simon, Shpiro, Natalia, Marquez, Rodolfo, Morrice, Nick, Bain, Jenny, Espel, Enric, Proud, Christopher G

“…Posttranscriptional regulatory mechanisms control TNFα expression through AU-rich elements in the 3'UTR of its mRNA. This is mediated through Erk and p38 MAP…”
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New 2-bromomethyl-8-substituted-benzo[c]chromen-6-ones. Synthesis and biological properties by Garino, Cédrik, Bihel, Frédéric, Pietrancosta, Nicolas, Laras, Younes, Quéléver, Gilles, Woo, Irene, Klein, Peter, Bain, Jenny, Boucher, Jean-Luc, Kraus, Jean-Louis

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