Search Results - "Bailey, Suzanna L."

The Crystal Structure of TREX1 Explains the 3′ Nucleotide Specificity and Reveals a Polyproline II Helix for Protein Partnering by de Silva, Udesh, Choudhury, Sumana, Bailey, Suzanna L., Harvey, Scott, Perrino, Fred W., Hollis, Thomas

“…The TREX1 enzyme processes DNA ends as the major 3′ → 5′ exonuclease activity in human cells. Mutations in the TREX1 gene are an underlying cause of the…”
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Defects in DNA degradation revealed in crystal structures of TREX1 exonuclease mutations linked to autoimmune disease by Bailey, Suzanna L., Harvey, Scott, Perrino, Fred W., Hollis, Thomas

“…► In this study we determine the crystal structures of TREX1 mutants linked to autoimmune disease. ► The structures reveal changes in the architecture of the…”
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Cancer-Associated SF3B1 Hotspot Mutations Induce Cryptic 3′ Splice Site Selection through Use of a Different Branch Point by Darman, Rachel B., Seiler, Michael, Agrawal, Anant A., Lim, Kian H., Peng, Shouyong, Aird, Daniel, Bailey, Suzanna L., Bhavsar, Erica B., Chan, Betty, Colla, Simona, Corson, Laura, Feala, Jacob, Fekkes, Peter, Ichikawa, Kana, Keaney, Gregg F., Lee, Linda, Kumar, Pavan, Kunii, Kaiko, MacKenzie, Crystal, Matijevic, Mark, Mizui, Yoshiharu, Myint, Khin, Park, Eun Sun, Puyang, Xiaoling, Selvaraj, Anand, Thomas, Michael P., Tsai, Jennifer, Wang, John Y., Warmuth, Markus, Yang, Hui, Zhu, Ping, Garcia-Manero, Guillermo, Furman, Richard R., Yu, Lihua, Smith, Peter G., Buonamici, Silvia

“…Recurrent mutations in the spliceosome are observed in several human cancers, but their functional and therapeutic significance remains elusive. SF3B1, the…”
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Mutations in the gene encoding the 3′-5′ DNA exonuclease TREX1 are associated with systemic lupus erythematosus by Gong, Maolian, Lee, Young-Ae, Wong, Andrew, Hollis, Thomas, Lieberman, Judy, Pfeiffer, Christiane, Schmidt, Reinhold E, Koskenmies, Sari, Engel, Kerstin, Lee-Kirsch, Min Ae, Rohde, Klaus, Hübner, Norbert, Hummel, Oliver, Harvey, Scott, Dominiczak, Anna F, Perrino, Fred W, Chowdhury, Dipanjan, Vyse, Timothy J, Bailey, Suzanna L, Senenko, Lydia, de Silva, Udesh, Gahr, Manfred, Kere, Juha, Witte, Torsten

“…TREX1 acts in concert with the SET complex in granzyme A-mediated apoptosis, and mutations in TREX1 cause Aicardi-Goutières syndrome and familial chilblain…”
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Physical and Structural Basis for the Strong Interactions of the -ImPy- Central Pairing Motif in the Polyamide f-ImPyIm by Buchmueller, Karen L, Bailey, Suzanna L, Matthews, David A, Taherbhai, Zarmeen T, Register, Janna K, Davis, Zachary S, Bruce, Chrystal D, O'Hare, Caroline, Hartley, John A, Lee, Moses

“…The polyamide f-ImPyIm has a higher affinity for its cognate DNA than either the parent analogue, distamycin A (10-fold), or the structural isomer, f-PyImIm…”
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Molecular recognition of DNA base pairs by the formamido/pyrrole and formamido/imidazole pairings in stacked polyamides by Buchmueller, Karen L., Staples, Andrew M., Uthe, Peter B., Howard, Cameron M., Pacheco, Kimberly A. O., Cox, Kari K., Henry, James A., Bailey, Suzanna L., Horick, Sarah M., Nguyen, Binh, Wilson, W. David, Lee, Moses

“…Polyamides containing an N-terminal formamido (f) group bind to the minor groove of DNA as staggered, antiparallel dimers in a sequence-specific manner. The…”
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Targeting the Inverted CCAAT Box 2 in the Topoisomerase IIα Promoter by JH-37, an Imidazole−Pyrrole Polyamide Hairpin:  Design, Synthesis, Molecular Biology, and Biophysical Studies by Henry, James A, Le, N. Minh, Nguyen, Binh, Howard, Cameron M, Bailey, Suzanna L, Horick, Sarah M, Buchmueller, Karen L, Kotecha, Minal, Hochhauser, Daniel, Hartley, John A, Wilson, W. David, Lee, Moses

“…The topoisomerase IIα promoter is regulated through transcription factor interactions with five inverted CCAAT boxes (ICBs). In confluent cancer cells, binding…”
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Design of a Hairpin Polyamide, ZT65B, for Targeting the Inverted CCAAT Box (ICB) Site in the Multidrug Resistant (MDR1) Gene by Buchmueller, Karen L, Taherbhai, Zarmeen, Howard, Cameron M, Bailey, Suzanna L, Nguyen, Binh, O'Hare, Caroline, Hochhauser, Daniel, Hartley, John A, Wilson, W. David, Lee, Moses

“…A novel hairpin polyamide, ZT65B, containing a 3‐methylpicolinate moiety was designed to target the inverted CCAAT box (ICB) of the human multidrug resistance…”
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The Crystal Structure of TREX1 Explains the 3′ Nucleotide Specificity and Reveals a Polyproline II Helix for Protein Partnering by Udesh de Silva, Sumana Choudhury, Suzanna L. Bailey, Scott Harvey, Fred W. Perrino, Thomas Hollis

“…The TREX1 enzyme processes DNA ends as the major 3′ → 5′ exonuclease activity in human cells. Mutations in the TREX1 gene are an underlying cause of the…”
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The TREX1 3' exonuclease and autoimmune disease: Structural and biochemical analysis of disease mutants involved in autoimmune dysfunction by Bailey, Suzanna L

“…The homodimeric TREX1 protein is a member of the DnaQ family of exonucleases and catalyzes the major 3' exonuclease activity detected in mammalian cell…”
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Targeting the inverted CCAAT box 2 in the topoisomerase IIalpha promoter by JH-37, an imidazole-pyrrole polyamide hairpin: design, synthesis, molecular biology, and biophysical studies by Henry, James A, Le, N Minh, Nguyen, Binh, Howard, Cameron M, Bailey, Suzanna L, Horick, Sarah M, Buchmueller, Karen L, Kotecha, Minal, Hochhauser, Daniel, Hartley, John A, Wilson, W David, Lee, Moses

“…The topoisomerase IIalpha promoter is regulated through transcription factor interactions with five inverted CCAAT boxes (ICBs). In confluent cancer cells,…”
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The TREX1 3' exonuclease and autoimmune disease: Structural and biochemical analysis of disease mutants involved in autoimmune dysfunction by Bailey, Suzanna L

“…The homodimeric TREX1 protein is a member of the DnaQ family of exonucleases and catalyzes the major 3' exonuclease activity detected in mammalian cell…”
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