Search Results - "Bailey, Sean T."

Individual cristae within the same mitochondrion display different membrane potentials and are functionally independent by Wolf, Dane M, Segawa, Mayuko, Kondadi, Arun Kumar, Anand, Ruchika, Bailey, Sean T, Reichert, Andreas S, van der Bliek, Alexander M, Shackelford, David B, Liesa, Marc, Shirihai, Orian S

“…The mitochondrial membrane potential (ΔΨ m ) is the main driver of oxidative phosphorylation (OXPHOS). The inner mitochondrial membrane (IMM), consisting of…”
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In vivo imaging of mitochondrial membrane potential in non-small-cell lung cancer by Momcilovic, Milica, Jones, Anthony, Bailey, Sean T., Waldmann, Christopher M., Li, Rui, Lee, Jason T., Abdelhady, Gihad, Gomez, Adrian, Holloway, Travis, Schmid, Ernst, Stout, David, Fishbein, Michael C., Stiles, Linsey, Dabir, Deepa V., Dubinett, Steven M., Christofk, Heather, Shirihai, Orian, Koehler, Carla M., Sadeghi, Saman, Shackelford, David B.

“…Mitochondria are essential regulators of cellular energy and metabolism, and have a crucial role in sustaining the growth and survival of cancer cells. A…”
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Sodium-glucose transporter 2 is a diagnostic and therapeutic target for early-stage lung adenocarcinoma by Scafoglio, Claudio R, Villegas, Brendon, Abdelhady, Gihad, Bailey, Sean T, Liu, Jie, Shirali, Aditya S, Wallace, W Dean, Magyar, Clara E, Grogan, Tristan R, Elashoff, David, Walser, Tonya, Yanagawa, Jane, Aberle, Denise R, Barrio, Jorge R, Dubinett, Steven M, Shackelford, David B

“…The diagnostic definition of indeterminate lung nodules as malignant or benign poses a major challenge for clinicians. We discovered a potential marker, the…”
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Targeted Inhibition of EGFR and Glutaminase Induces Metabolic Crisis in EGFR Mutant Lung Cancer by Momcilovic, Milica, Bailey, Sean T., Lee, Jason T., Fishbein, Michael C., Magyar, Clara, Braas, Daniel, Graeber, Thomas, Jackson, Nicholas J., Czernin, Johannes, Emberley, Ethan, Gross, Matthew, Janes, Julie, Mackinnon, Andy, Pan, Alison, Rodriguez, Mirna, Works, Melissa, Zhang, Winter, Parlati, Francesco, Demo, Susan, Garon, Edward, Krysan, Kostyantyn, Walser, Tonya C., Dubinett, Steven M., Sadeghi, Saman, Christofk, Heather R., Shackelford, David B.

“…Cancer cells exhibit increased use of nutrients, including glucose and glutamine, to support the bioenergetic and biosynthetic demands of proliferation. We…”
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MYC activation cooperates with Vhl and Ink4a/Arf loss to induce clear cell renal cell carcinoma by Bailey, Sean T., Smith, Aleisha M., Kardos, Jordan, Wobker, Sara E., Wilson, Harper L., Krishnan, Bhavani, Saito, Ryoichi, Lee, Hyo Jin, Zhang, Jing, Eaton, Samuel C., Williams, Lindsay A., Manocha, Ujjawal, Peters, Dorien J., Pan, Xinchao, Carroll, Thomas J., Felsher, Dean W., Walter, Vonn, Zhang, Qing, Parker, Joel S., Yeh, Jen Jen, Moffitt, Richard A., Leung, Janet Y., Kim, William Y.

“…Renal carcinoma is a common and aggressive malignancy whose histopathogenesis is incompletely understood and that is largely resistant to cytotoxic…”
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State of the science: an update on renal cell carcinoma by Jonasch, Eric, Futreal, P Andrew, Davis, Ian J, Bailey, Sean T, Kim, William Y, Brugarolas, James, Giaccia, Amato J, Kurban, Ghada, Pause, Armin, Frydman, Judith, Zurita, Amado J, Rini, Brian I, Sharma, Pam, Atkins, Michael B, Walker, Cheryl L, Rathmell, W Kimryn

“…Renal cell carcinomas (RCC) are emerging as a complex set of diseases that are having a major socioeconomic impact and showing a continued rise in incidence…”
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Metabolic and functional genomic studies identify deoxythymidylate kinase as a target in LKB1-mutant lung cancer by Liu, Yan, Marks, Kevin, Cowley, Glenn S, Carretero, Julian, Liu, Qingsong, Nieland, Thomas J F, Xu, Chunxiao, Cohoon, Travis J, Gao, Peng, Zhang, Yong, Chen, Zhao, Altabef, Abigail B, Tchaicha, Jeremy H, Wang, Xiaoxu, Choe, Sung, Driggers, Edward M, Zhang, Jianming, Bailey, Sean T, Sharpless, Norman E, Hayes, D Neil, Patel, Nirali M, Janne, Pasi A, Bardeesy, Nabeel, Engelman, Jeffrey A, Manning, Brendan D, Shaw, Reuben J, Asara, John M, Scully, Ralph, Kimmelman, Alec, Byers, Lauren A, Gibbons, Don L, Wistuba, Ignacio I, Heymach, John V, Kwiatkowski, David J, Kim, William Y, Kung, Andrew L, Gray, Nathanael S, Root, David E, Cantley, Lewis C, Wong, Kwok-Kin

“…The LKB1/STK11 tumor suppressor encodes a serine/threonine kinase, which coordinates cell growth, polarity, motility, and metabolism. In non-small cell lung…”
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Erythropoietin promotes breast tumorigenesis through tumor-initiating cell self-renewal by Zhou, Bing, Damrauer, Jeffrey S, Bailey, Sean T, Hadzic, Tanja, Jeong, Youngtae, Clark, Kelly, Fan, Cheng, Murphy, Laura, Lee, Cleo Y, Troester, Melissa A, Miller, C Ryan, Jin, Jian, Darr, David, Perou, Charles M, Levine, Ross L, Diehn, Maximilian, Kim, William Y

“…Erythropoietin (EPO) is a hormone that induces red blood cell production. In its recombinant form, EPO is the one of most prescribed drugs to treat anemia,…”
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mTOR inhibition induces compensatory, therapeutically targetable MEK activation in renal cell carcinoma by Bailey, Sean T, Zhou, Bing, Damrauer, Jeffrey S, Krishnan, Bhavani, Wilson, Harper L, Smith, Aleisha M, Li, Mingqing, Yeh, Jen Jen, Kim, William Y

“…Rapamycin derivatives allosterically targeting mTOR are currently FDA approved to treat advanced renal cell carcinoma (RCC), and catalytic inhibitors of…”
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Leptin stimulates pituitary prolactin release through an extracellular signal-regulated kinase-dependent pathway by Tipsmark, Christian K, Strom, Christina N, Bailey, Sean T, Borski, Russell J

“…Leptin was initially identified as a regulator of appetite and weight control centers in the hypothalamus, but appears to be involved in a number of…”
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The GSK3 Signaling Axis Regulates Adaptive Glutamine Metabolism in Lung Squamous Cell Carcinoma by Momcilovic, Milica, Bailey, Sean T., Lee, Jason T., Fishbein, Michael C., Braas, Daniel, Go, James, Graeber, Thomas G., Parlati, Francesco, Demo, Susan, Li, Rui, Walser, Tonya C., Gricowski, Michael, Shuman, Robert, Ibarra, Julio, Fridman, Deborah, Phelps, Michael E., Badran, Karam, St. John, Maie, Bernthal, Nicholas M., Federman, Noah, Yanagawa, Jane, Dubinett, Steven M., Sadeghi, Saman, Christofk, Heather R., Shackelford, David B.

“…Altered metabolism is a hallmark of cancer growth, forming the conceptual basis for development of metabolic therapies as cancer treatments. We performed…”
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Entinostat induces antitumor immune responses through immune editing of tumor neoantigens by Truong, Andrew S, Zhou, Mi, Krishnan, Bhavani, Utsumi, Takanobu, Manocha, Ujjawal, Stewart, Kyle G, Beck, Wolfgang, Rose, Tracy L, Milowsky, Matthew I, He, Xiaping, Smith, Christof C, Bixby, Lisa M, Perou, Charles M, Wobker, Sara E, Bailey, Sean T, Vincent, Benjamin G, Kim, William Y

“…Although immune-checkpoint inhibitors (ICIs) have been a remarkable advancement in bladder cancer treatment, the response rate to single-agent ICIs remains…”
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HIF1α and HIF2α independently activate SRC to promote melanoma metastases by Hanna, Sara C, Krishnan, Bhavani, Bailey, Sean T, Moschos, Stergios J, Kuan, Pei-Fen, Shimamura, Takeshi, Osborne, Lukas D, Siegel, Marni B, Duncan, Lyn M, O'Brien, 3rd, E Tim, Superfine, Richard, Miller, C Ryan, Simon, M Celeste, Wong, Kwok-Kin, Kim, William Y

“…Malignant melanoma is characterized by a propensity for early lymphatic and hematogenous spread. The hypoxia-inducible factor (HIF) family of transcription…”
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Publisher Correction: In vivo imaging of mitochondrial membrane potential in non-small-cell lung cancer by Momcilovic, Milica, Jones, Anthony, Bailey, Sean T., Waldmann, Christopher M., Li, Rui, Lee, Jason T., Abdelhady, Gihad, Gomez, Adrian, Holloway, Travis, Schmid, Ernst, Stout, David, Fishbein, Michael C., Stiles, Linsey, Dabir, Deepa V., Dubinett, Steven M., Christofk, Heather, Shirihai, Orian, Koehler, Carla M., Sadeghi, Saman, Shackelford, David B.

“…An Amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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An Automated Multidose Synthesis of the Potentiometric PET Probe 4-[18F]Fluorobenzyl-Triphenylphosphonium ([18F]FBnTP) by Waldmann, Christopher M., Gomez, Adrian, Marchis, Phillip, Bailey, Sean T., Momcilovic, Milica, Jones, Anthony E., Shackelford, David B., Sadeghi, Saman

“…Purpose The aim of this study was the automated synthesis of the mitochondrial membrane potential sensor 4-[ 18 F]fluorobenzyl-triphenylphosphonium ([ 18…”
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Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer by Momcilovic, Milica, Bailey, Sean T, Lee, Jason T, Zamilpa, Charles, Jones, Anthony, Abdelhady, Gihad, Mansfield, James, Francis, Kevin P, Shackelford, David B

“…A hallmark of advanced tumors is a switch to aerobic glycolysis that is readily measured by [ F]-2-fluoro-2-deoxy-D-glucose positron emission tomography (…”
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Targeted inhibition of gut bacterial β-glucuronidase activity enhances anticancer drug efficacy by Bhatt, Aadra P., Pellock, Samuel J., Biernat, Kristen A., Walton, William G., Wallace, Bret D., Creekmore, Benjamin C., Letertre, Marine M., Swann, Jonathan R., Wilson, Ian D., Roques, Jose R., Darr, David B., Bailey, Sean T., Montgomery, Stephanie A., Roach, Jeffrey M., Azcarate-Peril, M. Andrea, Sartor, R. Balfour, Gharaibeh, Raad Z., Bultman, Scott J., Redinbo, Matthew R.

“…Irinotecan treats a range of solid tumors, but its effectiveness is severely limited by gastrointestinal (GI) tract toxicity caused by gut bacterial…”
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Abstract A13: Entinostat enhances antitumor immune responses and cooperates with PD-1 blockade in bladder cancer mouse models by Truong, Andrew S., Zhou, Mi, Utsumi, Takanobu, Krishnan, Bhavani, Stewart, Kyle G., Saito, Ryoichi, Manocha, Ujjawal, Bailey, Sean T., Kim, William Y.

“…Abstract Bladder cancer harbors a high frequency of somatic mutations that occur randomly across the genome. A fraction of these mutations can be expressed and…”
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Abstract 2748: Antitumor activity of HDAC inhibition in bladder cancer mouse models correlates with enhanced immune response by Stewart, Kyle G., Truong, Andrew S., Krishnan, Bhavani, Zhou, Mi, Saito, Ryoichi, Kardos, Jordan, Manocha, Ujjawal, Bailey, Sean T., Kim, William Y.

“…Abstract Aberrant chromatin remodeling by epigenetic modifier proteins such as histone deacetylases (HDACs) is common within many types of cancer, including…”
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Abstract A16: Sodium-dependent glucose transporter 2 is a novel diagnostic and therapeutic target for early-stage lung adenocarcinoma by Scafoglio, Claudio, Bailey, Sean T., Abdelhady, Gihad, Liu, Jie, Yanagawa, Jane, Shirali, Aditya, Wallace, Dean W., Barrio, Jorge R., Wright, Ernest M., Walser, Tonya, Dubinett, Steven M., Shackelford, David B.

“…Abstract Lung cancer claims approximately 160,000 lives in the United States every year, and lung adenocarcinoma (LADC) is the most frequent type. Early…”
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