Search Results - "Bailey, Sarah K."

Inhibition of Hedgehog signaling reprograms the dysfunctional immune microenvironment in breast cancer by Hanna, Ann, Metge, Brandon J., Bailey, Sarah K., Chen, Dongquan, Chandrashekar, Darshan S., Varambally, Sooryanarayana, Samant, Rajeev S., Shevde, Lalita A.

“…Host responses to tumor cells include tumor suppressing or promoting mechanisms. We sought to detail the effect of Hedgehog (Hh) pathway inhibition on the…”
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Deficiency of tumor suppressor Merlin facilitates metabolic adaptation by co-operative engagement of SMAD-Hippo signaling in breast cancer by Mota, Mateus S V, Jackson, William P, Bailey, Sarah K, Vayalil, Praveen, Landar, Aimee, Rostas, Jack W, Mulekar, Madhuri S, Samant, Rajeev S, Shevde, Lalita A

“…Merlin deficiency elicits the co-operative activity of the Hippo and TGF-β pathways to disengage restriction on STAT3 and hexokinase 2, enabling a metabolic…”
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Genomic regulation of invasion by STAT3 in triple negative breast cancer by McDaniel, Joy M, Varley, Katherine E, Gertz, Jason, Savic, Daniel S, Roberts, Brian S, Bailey, Sarah K, Shevde, Lalita A, Ramaker, Ryne C, Lasseigne, Brittany N, Kirby, Marie K, Newberry, Kimberly M, Partridge, E Christopher, Jones, Angela L, Boone, Braden, Levy, Shawn E, Oliver, Patsy G, Sexton, Katherine C, Grizzle, William E, Forero, Andres, Buchsbaum, Donald J, Cooper, Sara J, Myers, Richard M

“…Breast cancer is a heterogeneous disease comprised of four molecular subtypes defined by whether the tumor-originating cells are luminal or basal epithelial…”
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Induction of KLF4 in basal keratinocytes blocks the proliferation-differentiation switch and initiates squamous epithelial dysplasia by FOSTER, K. Wade, ZHAOLI LIU, KUDLOW, Jeffrey E, LOBO-RUPPERT, Susan M, RUPPERT, J. Michael, NAIL, Clinton D, XINGNAN LI, FITZGERALD, Thomas J, BAILEY, Sarah K, FROST, Andra R, LOURO, Iuri D, TOWNES, Tim M, PATERSON, Andrew J

“…KLF4/GKLF normally functions in differentiating epithelial cells, but also acts as a transforming oncogene in vitro. To examine the role of this zinc finger…”
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O-GlcNAcylation of GLI transcription factors in hyperglycemic conditions augments Hedgehog activity by Das, Shamik, Bailey, Sarah K., Metge, Brandon J., Hanna, Ann, Hinshaw, Dominique C., Mota, Mateus, Forero-Torres, Andres, Chatham, John C., Samant, Rajeev S., Shevde, Lalita A.

“…Modification of proteins by O-linked β-N-acetylglucosamine (O-GlcNAc) promotes tumor cell survival, proliferation, epigenetic changes, angiogenesis, invasion,…”
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microRNA-29 negatively regulates EMT regulator N-myc interactor in breast cancer by Rostas, 3rd, Jack W, Pruitt, Hawley C, Metge, Brandon J, Mitra, Aparna, Bailey, Sarah K, Bae, Sejong, Singh, Karan P, Devine, Daniel J, Dyess, Donna L, Richards, William O, Tucker, J Allan, Shevde, Lalita A, Samant, Rajeev S

“…N-Myc Interactor is an inducible protein whose expression is compromised in advanced stage breast cancer. Downregulation of NMI, a gatekeeper of epithelial…”
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Loss of tumor suppressor Merlin results in aberrant activation of Wnt/β-catenin signaling in cancer by Morrow, K Adam, Das, Shamik, Meng, Erhong, Menezes, Mitchell E, Bailey, Sarah K, Metge, Brandon J, Buchsbaum, Donald J, Samant, Rajeev S, Shevde, Lalita A

“…The expression of the tumor suppressor Merlin is compromised in nervous system malignancies due to genomic aberrations. We demonstrated for the first time,…”
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Loss of Merlin induces metabolomic adaptation that engages dependence on Hedgehog signaling by Das, Shamik, Jackson, William P., Prasain, Jeevan K., Hanna, Ann, Bailey, Sarah K., Tucker, J. Allan, Bae, Sejong, Wilson, Landon S., Samant, Rajeev S., Barnes, Stephen, Shevde, Lalita A.

“…The tumor suppressor protein Merlin is proteasomally degraded in breast cancer. We undertook an untargeted metabolomics approach to discern the global…”
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Identification of initial leads directed at the calmodulin-binding region on the Src-SH2 domain that exhibit anti-proliferation activity against pancreatic cancer by Tzou, Ywh-Min, Bailey, Sarah K., Yuan, Kaiyu, Shin, Ronald, Zhang, Wei, Chen, Yabing, Singh, Raj K., Shevde, Lalita A., Rama Krishna, N.

“…[Display omitted] Cellular calmodulin binds to the SH2 domain of Src kinase, and upon Fas activation it recruits Src into the death-inducing signaling complex…”
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Epithelial transformation by KLF4 requires Notch1 but not canonical Notch1 signaling by Liu, Zhaoli, Teng, Lihong, Bailey, Sarah, Frost, Andra R., Bland, Kirby I., LoBuglio, Albert F., Ruppert, J. Michael, Lobo-Ruppert, Susan M.

“…The transcription factors Notch1 and KLF4 specify epithelial cell fates and confer stem cell properties.  Suggesting a functional relationship, each gene can…”
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KLF4 and PCNA identify stages of tumor initiation in a conditional model of cutaneous squamous epithelial neoplasia by Huang, Conway C., Liu, Zhaoli, Li, Xingnan, Bailey, Sarah, Nail, Clinton D., Foster, K. Wade, Frost, Andra R., Ruppert, J. Michael, Lobo-Ruppert, Susan M.

“…KLF4 is induced upon growth-arrest in vitro and during epithelial maturation in vivo, and is essential for proper cell fate specification of post-mitotic…”
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Prevention of KLF4-mediated tumor initiation and malignant transformation by UAB30 rexinoid by Jiang, Wen, Deng, Wentao, Bailey, Sarah, Nail, Clint D., Frost, Andra R., Brouillette, Wayne J., Muccio, Donald D., Grubbs, Clinton J., Lobo-ruppert, Susan M, Ruppert, J. Michael

“…The transcription factor KLF4 functions in post-mitotic epithelial cells to promote differentiation, and functions in a context-dependent fashion as an…”
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Abstract 657: N-Myc and STAT Interactor knock out in the mammary epithelium prompts hyper-proliferation by Pruitt, Hawley C., Metge, Brandon J., Bailey, Sarah K., Shevde, Lalita A., Samant, Rajeev S.

“…Abstract N-Myc and STAT Interactor (NMI) is an evolutionarily conserved protein that is widely expressed in fetal and adult tissues. Early studies implicated…”
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O-GlcNAcylation of GLI Transcription Factors in Hyperglycemic Conditions Augments Hedgehog activity: Hyperglycemic conditions upregulate GLI activity by Das, Shamik, Bailey, Sarah K., Metge, Brandon J., Hanna, Ann, Hinshaw, Dominique C., Mota, Mateus, Forero-Torres, Andres, Chatham, John C., Samant, Rajeev S., Shevde, Lalita A.

“…Modification of proteins by O-linked β- N -acetylglucosamine (O-GlcNAc) promotes tumor cell survival, proliferation, epigenetic changes, angiogenesis,…”
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Snail induction is an early response to Gli1 that determines the efficiency of epithelial transformation by LI, X, DENG, W, NAIL, C. D, BAILEY, S. K, KRAUS, M. H, RUPPERT, J. M, LOBO-RUPPERT, S. M

“…Gli family members mediate constitutive Hedgehog signaling in the common skin cancer, basal cell carcinoma (BCC). Snail/Snai1 is rapidly induced by Gli1 in…”
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Abstract 2466: The tumor suppressor Merlin decreases TGFβ/Smad signaling in metastatic breast cancer cells by Jackson, William P., Kreitzburg, Kelly M., Das, Shamik, Bailey, Sarah K., Metge, Brandon J., Samant, Rajeev S., Shevde-Samant, Lalita R.

“…Abstract Background: Merlin is a tumor suppressor protein encoded by the NF2 gene. Mutations in NF2 have been implicated in neurofibromas, schwannomas, and…”
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Abstract 4010: MicroRNA regulator of NMI: implications for breast cancer by Pruitt, Hawley C., III, Jack W. Rostas, Metge, Brandon J., Devine, Daniel J., Bailey, Sarah K., Shevde, Lalita A., Samant, Rajeev

“…Abstract Recent investigations by our laboratory have demonstrated that NMI expression is down-regulated in patient breast tumors, especially those displaying…”
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