Search Results - "Bailey, Samantha L"

Self-antigen-Driven Activation Induces Instability of Regulatory T Cells during an Inflammatory Autoimmune Response by Bailey-Bucktrout, Samantha L., Martinez-Llordella, Marc, Zhou, Xuyu, Anthony, Bryan, Rosenthal, Wendy, Luche, Herve, Fehling, Hans J., Bluestone, Jeffrey A.

“…Stable Foxp3 expression is crucial for regulatory T (Treg) cell function. We observed that antigen-driven activation and inflammation in the CNS promoted Foxp3…”
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Epitope spreading initiates in the CNS in two mouse models of multiple sclerosis by Miller, Stephen D, McMahon, Eileen J, Bailey, Samantha L, Castenada, Carol Vanderlugt, Waldner, Hanspeter

“…Chronic progression of two T cell-mediated central nervous system (CNS) demyelinating models of multiple sclerosis, relapsing EAE (R-EAE) and Theiler's murine…”
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Dendritic cells with TGF-β1 differentiate naïve CD4⁺CD25⁻ T cells into islet-protective Foxp3⁺ regulatory T cells by Luo, Xunrong, Tarbell, Kristin V, Yang, Hua, Pothoven, Kathryn, Bailey, Samantha L, Ding, Ruchuang, Steinman, Ralph M, Suthanthiran, Manikkam

“…CD4⁺CD25⁺Foxp3⁺ regulatory T cells (T regs) are important for preventing autoimmune diabetes and are either thymic-derived (natural) or differentiated in the…”
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Antigen Presentation in the CNS by Myeloid Dendritic Cells Drives Progression of Relapsing Experimental Autoimmune Encephalomyelitis by MILLER, STEPHEN D., McMAHON, EILEEN J., SCHREINER, BETTINA, BAILEY, SAMANTHA L.

“…:  Chronic progression of relapsing experimental autoimmune encephalomyelitis (R‐EAE), a mouse model of multiple sclerosis (MS), is dependent on the activation…”
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CNS myeloid DCs presenting endogenous myelin peptides 'preferentially' polarize CD4+ TH-17 cells in relapsing EAE by Bailey, Samantha L, Schreiner, Bettina, McMahon, Eileen J, Miller, Stephen D

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CNS myeloid DCs presenting endogenous myelin peptides 'preferentially' polarize CD4 + T H -17 cells in relapsing EAE by Miller, Stephen D, Bailey, Samantha L, Schreiner, Bettina, McMahon, Eileen J

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Innate and Adaptive Immune Responses of the Central Nervous System by Bailey, Samantha L., Carpentier, Pamela A., McMahon, Eileen J., Begolka, Wendy Smith, Miller, Stephen D.

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PD-1 ligands expressed on myeloid-derived APC in the CNS regulate T-cell responses in EAE by Schreiner, Bettina, Bailey, Samantha L, Shin, Tahiro, Chen, Lieping, Miller, Stephen D

“…Disease progression in experimental autoimmune encephalomyelitis (EAE) is regulated by programmed death receptor 1 (PD-1) and its ligands, B7-H1 (programmed…”
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Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo by Bluestone, Jeffrey A, Zhou, Xuyu, Bailey-Bucktrout, Samantha L, Jeker, Lukas T, Penaranda, Cristina, Martínez-Llordella, Marc, Ashby, Meredith, Nakayama, Maki, Rosenthal, Wendy

“…The stability of expression of the transcription factor Foxp3 in vivo has not been thoroughly assessed. Bluestone and colleagues find that Foxp3 expression can…”
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CNS dendritic cells: Critical participants in CNS inflammation? by McMahon, Eileen J., Bailey, Samantha L., Miller, Stephen D.

“…Dendritic cells (DCs) are a heterogeneous population of migratory cells specialized for the uptake, processing, and presentation of antigen to T cells. They…”
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Regulatory T cells: stability revisited by Bailey-Bucktrout, Samantha L, Bluestone, Jeffrey A

“…Breakdown in self-tolerance is caused, in part, by loss of regulatory T (Treg) cells. Recently, a controversy has surfaced about whether Treg cells are…”
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The integrated stress response prevents demyelination by protecting oligodendrocytes against immune-mediated damage by Lin, Wensheng, Bailey, Samantha L, Ho, Hanson, Harding, Heather P, Ron, David, Miller, Stephen D, Popko, Brian

“…In response to ER stress, the pancreatic endoplasmic reticulum kinase (PERK) coordinates an adaptive program known as the integrated stress response (ISR) by…”
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ICOS Promotes the Function of CD4+ Effector T Cells during Anti-OX40-Mediated Tumor Rejection by Metzger, Todd C, Long, Hua, Potluri, Shobha, Pertel, Thomas, Bailey-Bucktrout, Samantha L, Lin, John C, Fu, Tihui, Sharma, Padmanee, Allison, James P, Feldman, Reid M R

“…ICOS is a T-cell coregulatory receptor that provides a costimulatory signal to T cells during antigen-mediated activation. Antitumor immunity can be improved…”
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Expression of αvβ8 integrin on dendritic cells regulates Th17 cell development and experimental autoimmune encephalomyelitis in mice by Melton, Andrew C, Bailey-Bucktrout, Samantha L, Travis, Mark A, Fife, Brian T, Bluestone, Jeffrey A, Sheppard, Dean

“…Th17 cells promote a variety of autoimmune diseases, including psoriasis, multiple sclerosis, rheumatoid arthritis, and inflammatory bowel disease. TGF-β is…”
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CD28-inducible transcription factor DEC1 is required for efficient autoreactive CD4+ T cell response by Martínez-Llordella, Marc, Esensten, Jonathan H, Bailey-Bucktrout, Samantha L, Lipsky, Robert H, Marini, Ann, Chen, Jun, Mughal, Mohamed, Mattson, Mark P, Taub, Dennis D, Bluestone, Jeffrey A

“…During the initial hours after activation, CD4(+) T cells experience profound changes in gene expression. Co-stimulation via the CD28 receptor is required for…”
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Repression of the genome organizer SATB1 in regulatory T cells is required for suppressive function and inhibition of effector differentiation by Beyer, Marc, Thabet, Yasser, Müller, Roman-Ulrich, Sadlon, Timothy, Classen, Sabine, Lahl, Katharina, Basu, Samik, Zhou, Xuyu, Bailey-Bucktrout, Samantha L, Krebs, Wolfgang, Schönfeld, Eva A, Böttcher, Jan, Golovina, Tatiana, Mayer, Christian T, Hofmann, Andrea, Sommer, Daniel, Debey-Pascher, Svenja, Endl, Elmar, Limmer, Andreas, Hippen, Keli L, Blazar, Bruce R, Balderas, Robert, Quast, Thomas, Waha, Andreas, Mayer, Günter, Famulok, Michael, Knolle, Percy A, Wickenhauser, Claudia, Kolanus, Waldemar, Schermer, Bernhard, Bluestone, Jeffrey A, Barry, Simon C, Sparwasser, Tim, Riley, James L, Schultze, Joachim L

“…The DNA-binding factor SATB1 is known as a chromatin organizer. Schultze and colleagues show regulation of SATB1 expression by the transcription factor Foxp3…”
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Cutting Edge: Central Nervous System Plasmacytoid Dendritic Cells Regulate the Severity of Relapsing Experimental Autoimmune Encephalomyelitis by Bailey-Bucktrout, Samantha L, Caulkins, Sarah C, Goings, Gwendolyn, Fischer, Jens A. A, Dzionek, Andrzej, Miller, Stephen D

“…Plasmacytoid dendritic cells (pDCs) have both stimulatory and regulatory effects on T cells. pDCs are a major CNS-infiltrating dendritic cell population during…”
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Innate and adaptive immune responses of the central nervous system by Bailey, Samantha L, Carpentier, Pamela A, McMahon, Eileen J, Begolka, Wendy Smith, Miller, Stephen D

“…The central nervous system (CNS) is an immunologically specialized organ. The blood-brain barrier regulates the passage of molecules and cells into the CNS…”
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CNS myeloid DCs presenting endogenous myelin peptides 'preferentially' polarize CD4+ TH-17 cells in relapsing EAE by Bailey, Samantha L, Schreiner, Bettina, McMahon, Eileen J, Miller, Stephen D

“…Peripherally derived CD11b(+) myeloid dendritic cells (mDCs), plasmacytoid DCs, CD8alpha(+) DCs and macrophages accumulate in the central nervous system during…”
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CNS myeloid DCs presenting endogenous myelin peptides 'preferentially' polarize [CD4.sup.+] [T.sub.H]-17 cells in relapsing EAE by Bailey, Samantha L, Schreiner, Bettina, McMahon, Eileen J, Miller, Stephen D

“…Peripherally derived [CD11b.sup.+] myeloid dendritic cells (mDCs), plasmacytoid DCs, [CD8α.sup.+] DCs and macrophages accumulate in the central nervous system…”
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