Search Results - "Bailey, L"
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STREME: accurate and versatile sequence motif discovery
Published in Bioinformatics (Oxford, England) (29-09-2021)“…Sequence motif discovery algorithms can identify novel sequence patterns that perform biological functions in DNA, RNA and protein sequences-for example, the…”
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DREME: motif discovery in transcription factor ChIP-seq data
Published in Bioinformatics (Oxford, England) (15-06-2011)“…Transcription factor (TF) ChIP-seq datasets have particular characteristics that provide unique challenges and opportunities for motif discovery. Most existing…”
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MEME-ChIP: motif analysis of large DNA datasets
Published in Bioinformatics (Oxford, England) (15-06-2011)“…Advances in high-throughput sequencing have resulted in rapid growth in large, high-quality datasets including those arising from transcription factor (TF)…”
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Statistical confidence estimation for Hi-C data reveals regulatory chromatin contacts
Published in Genome research (01-06-2014)“…Our current understanding of how DNA is packed in the nucleus is most accurate at the fine scale of individual nucleosomes and at the large scale of chromosome…”
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Globally rising soil heterotrophic respiration over recent decades
Published in Nature (London) (01-08-2018)“…Global soils store at least twice as much carbon as Earth’s atmosphere 1 , 2 . The global soil-to-atmosphere (or total soil respiration, R S ) carbon dioxide…”
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FIMO: scanning for occurrences of a given motif
Published in Bioinformatics (01-04-2011)“…A motif is a short DNA or protein sequence that contributes to the biological function of the sequence in which it resides. Over the past several decades, many…”
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Motif Enrichment Analysis: a unified framework and an evaluation on ChIP data
Published in BMC bioinformatics (01-04-2010)“…A major goal of molecular biology is determining the mechanisms that control the transcription of genes. Motif Enrichment Analysis (MEA) seeks to determine…”
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An evidence-based review of quantitative SPECT imaging and potential clinical applications
Published in Journal of Nuclear Medicine (01-01-2013)“…SPECT has traditionally been regarded as nonquantitative. Advances in multimodality γ-cameras (SPECT/CT), algorithms for image reconstruction, and…”
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Defining the RGG/RG Motif
Published in Molecular cell (06-06-2013)“…Motifs rich in arginines and glycines were recognized several decades ago to play functional roles and were termed glycine-arginine-rich (GAR) domains and/or…”
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Developing a molecular picture of soil organic matter–mineral interactions by quantifying organo–mineral binding
Published in Nature communications (30-08-2017)“…Long residence times of soil organic matter have been attributed to reactive mineral surface sites that sorb organic species and cause inaccessibility due to…”
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GT-Scan: identifying unique genomic targets
Published in Bioinformatics (Oxford, England) (15-09-2014)“…A number of technologies, including CRISPR/Cas, transcription activator-like effector nucleases and zinc-finger nucleases, allow the user to target a chosen…”
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What do we know about soil carbon destabilization?
Published in Environmental research letters (01-08-2019)“…Most empirical and modeling research on soil carbon (C) dynamics has focused on those processes that control and promote C stabilization. However, we lack a…”
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Improving occupancy estimation when two types of observational error occur: non-detection and species misidentification
Published in Ecology (Durham) (01-07-2011)“…Efforts to draw inferences about species occurrence frequently account for false negatives, the common situation when individuals of a species are not detected…”
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Polymer mimics of biomacromolecular antifreezes
Published in Nature communications (16-11-2017)“…Antifreeze proteins from polar fish species are remarkable biomacromolecules which prevent the growth of ice crystals. Ice crystal growth is a major problem in…”
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A Crisp(r) New Perspective on SARS-CoV-2 Biology
Published in Cell (07-01-2021)“…Complementary genome-wide CRISPR-Cas9 screens performed by multiple groups reveal new insights into SARS-CoV-2 biology including aspects of viral entry,…”
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SARS-CoV-2 infection of human ACE2-transgenic mice causes severe lung inflammation and impaired function
Published in Nature immunology (01-11-2020)“…Although animal models have been evaluated for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, none have fully recapitulated the lung…”
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Growth, detection, quantification, and inactivation of SARS-CoV-2
Published in Virology (New York, N.Y.) (01-09-2020)“…Severe acute respiratory syndrome coronavirus (SARS-CoV)-2 is the agent responsible for the coronavirus disease 2019 (COVID-19) global pandemic. SARS-CoV-2 is…”
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Loss of furin cleavage site attenuates SARS-CoV-2 pathogenesis
Published in Nature (London) (11-03-2021)“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)—a new coronavirus that has led to a worldwide pandemic 1 —has a furin cleavage site (PRRAR) in its…”
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Development and Initial Validation of the Risk Analysis Index for Measuring Frailty in Surgical Populations
Published in JAMA surgery (01-02-2017)“…Growing consensus suggests that frailty-associated risks should inform shared surgical decision making. However, it is not clear how best to screen for frailty…”
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Fruits, vegetables, and health: A comprehensive narrative, umbrella review of the science and recommendations for enhanced public policy to improve intake
Published in Critical reviews in food science and nutrition (19-07-2020)“…Fruit and vegetables (F&V) have been a cornerstone of healthy dietary recommendations; the 2015-2020 U.S. Dietary Guidelines for Americans recommend that F&V…”
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