Protective Effects of Sesame Glycoproteins on Ultraviolet-Induced Skin Aging: In Vitro and In Vivo Studies

Ultraviolet (UV) radiation is a primary factor in skin photoaging, leading to wrinkles, reduced elasticity, and pigmentation changes due to damage to cellular DNA, proteins, and lipids. Glycoproteins from sesame cake (SPE) have potential protective effects against UV-induced skin aging. This study i...

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Published in:	Pharmaceuticals (Basel, Switzerland) Vol. 17; no. 10; p. 1306
Main Authors:	Baik, Kyung Kyu, Song, Woo-Yong, Song, Dong Keun, Yun, Jaehyeok, Jang, Ji Hwan, Oh, Jae Young, Lee, Mi-Jin, Go, Eunjandi, Lee, Kyong Jin, Roh, Eunmiri, Kim, Jong-Eun
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 30-09-2024 MDPI
Subjects:	Aging Amino acids Antioxidants Care and treatment Chemical properties Collagen Cytotoxicity Dermatologic agents Dermatology DNA binding proteins Ethylenediaminetetraacetic acid Formulae, receipts, prescriptions Glycoproteins Health aspects Hydration Inflammation Kinases Molecular weight Oxidative stress Peptides Phosphorylation Physiological aspects Product development Proteins Radiation RNA Seeds Sesame sesame glycoproteins Skin Testing Transcription factors ultraviolet Ultraviolet radiation South Korea skin sesame glycoproteins aging ultraviolet
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Summary:	Ultraviolet (UV) radiation is a primary factor in skin photoaging, leading to wrinkles, reduced elasticity, and pigmentation changes due to damage to cellular DNA, proteins, and lipids. Glycoproteins from sesame cake (SPE) have potential protective effects against UV-induced skin aging. This study investigated the anti-photoaging effects of SPE on UV-induced damage in human keratinocyte HaCaT cells and SKH-1 hairless mice. SPE was evaluated for its ability to mitigate UV-induced damage in HaCaT cells by assessing MMP-1 protein and mRNA expression levels, as well as the activity of transcription factors AP-1 and NF-κB. The phosphorylation of AKT and MAPK pathways was also analyzed. In vivo, SKH-1 hairless mice were exposed to UV radiation, and the effects of SPE on wrinkle formation and skin structure were assessed by measuring wrinkle length, area, and volume. SPE significantly inhibited UV-induced MMP-1 protein and mRNA expression in HaCaT cells, indicating suppression of AP-1 and NF-κB transcription factors involved in MMP-1 production. Additionally, SPE reduced UV-induced phosphorylation of AKT and MAPK pathways. In SKH-1 hairless mice, SPE treatment led to significant reductions in wrinkle length, area, and volume, preserving skin structure in UV-exposed mice. The findings demonstrate that SPE has protective effects against UV-induced photoaging by inhibiting key molecular pathways associated with skin aging. SPE shows promise as a natural anti-photoaging agent, providing a foundation for future skincare product development. Further studies are warranted to explore the molecular mechanisms in detail and to validate these effects through clinical trials.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 These authors contributed equally to this work.
ISSN:	1424-8247 1424-8247
DOI:	10.3390/ph17101306