Ductal and Acinar Adenocarcinoma of Prostate: Morphological and Immunohistochemical Characterization

Ductal and Acinar Adenocarcinoma of Prostate Morphological and Immunohistochemical Characterization

Objectives: We sought to characterize the ductal and acinar subtype of prostate adenocarcinoma using hematoxylin and eosin (H&E) staining and an immunohistochemical antibody cocktail. We also investigated the clinical features, prostate-specific antigen (PSA) levels, and biological aggressivenes...

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Bibliographic Details
Published in:Oman medical journal Vol. 30; no. 3; pp. 162 - 166
Main Authors: Syed , Serajuddaula, Baig , Faraz A, Hamid , Amna, Mirza , Talat
Format: Journal Article
Language:English
Published: Muscat - Oman Oman Medical Specialty Board 01-05-2015
OMJ
Subjects:
Acinar Carcinoma
Adenocarcinoma
Cancer
Diagnosis
Ductal Carcinoma
Gleason Score
IMMUNITY
Immunohistochemistry
MALE GENITAL SYSTEM
MEDICAL SCIENCES
NEOPLASMS
Original
PROSTATE
PROSTATITIS
إلتهاب البروستات
الأورام
البروستات
الجهاز التناسلي الذكري
العلوم الطبية
المناعة
Adenocarcinoma
Immunohistochemistry
Gleason Score
Ductal Carcinoma
Prostate
Acinar Carcinoma
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Summary:Objectives: We sought to characterize the ductal and acinar subtype of prostate adenocarcinoma using hematoxylin and eosin (H&E) staining and an immunohistochemical antibody cocktail. We also investigated the clinical features, prostate-specific antigen (PSA) levels, and biological aggressiveness of these tumors. Methods: We utilized tumor bearing prostate biopsies, obtained between 2010 and 2014 from Dow Diagnostic Research and Reference Laboratory, to identify cases of prostatic ductal and acinar adenocarcinoma using routine H&E and immunohistochemical staining. The immunohistochemical antibody cocktail 34βE12/p63/AMACR was used for staining. The association of clinicopathological variables including patient’s age at diagnosis, Gleason score, and PSA levels before surgery was retrospectively analyzed. Results: A total of 10 ductal and 140 non-ductal cases were identified. Ductal cases were predominantly high grade with advanced histopathological features (90%; p=0.030). Marked elevation in PSA level was also reported in most cases. No other significant statistical difference was observed. Conclusions: Pathological and immunohistochemical examination could be used to characterize ductal and acinar adenocarcinoma of the prostate. Ductal adenocarcinoma of the prostate is a rare subtype of prostate carcinoma and is be more likely to present with advanced grade cancer suggesting that timely detection of the disease is vital.
Bibliography:Oman Medical Journal, Vol. 30, No. 3, May 2015: 162-166
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ISSN:1999-768X
2070-5204
DOI:10.5001/omj.2015.36