Search Results - "Baici, Antonio"

A novel allosteric mechanism in the cysteine peptidase cathepsin K discovered by computational methods by Novinec, Marko, Korenč, Matevž, Caflisch, Amedeo, Ranganathan, Rama, Lenarčič, Brigita, Baici, Antonio

“…Allosteric modifiers have the potential to fine-tune enzyme activity. Therefore, targeting allosteric sites is gaining increasing recognition as a strategy in…”
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Probing the activity modification space of the cysteine peptidase cathepsin K with novel allosteric modifiers by Novinec, Marko, Lenarčič, Brigita, Baici, Antonio

“…Targeting allosteric sites is gaining increasing recognition as a strategy for modulating the activity of enzymes, especially in drug design. Here we…”
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Specific Inhibition of β-Secretase Processing of the Alzheimer Disease Amyloid Precursor Protein by Ben Halima, Saoussen, Mishra, Sabyashachi, Raja, K. Muruga Poopathi, Willem, Michael, Baici, Antonio, Simons, Kai, Brüstle, Oliver, Koch, Philipp, Haass, Christian, Caflisch, Amedeo, Rajendran, Lawrence

“…Development of disease-modifying therapeutics is urgently needed for treating Alzheimer disease (AD). AD is characterized by toxic β-amyloid (Aβ) peptides…”
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Conformational flexibility and allosteric regulation of cathepsin K by Novinec, Marko, Kovacic, Lidija, Lenarcic, Brigita, Baici, Antonio

“…The human cysteine peptidase cathepsin K is a key enzyme in bone homoeostasis and other physiological functions. In the present study we investigate the…”
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Specific cleavage of agrin by neurotrypsin, a synaptic protease linked to mental retardation by Reif, Raymond, Sales, Susanne, Hettwer, Stefan, Dreier, Birgit, Gisler, Claudio, Wölfel, Jens, Lüscher, Daniel, Zurlinden, Andreas, Stephan, Alexander, Ahmed, Shaheen, Baici, Antonio, Ledermann, Birgit, Kunz, Beat, Sonderegger, Peter

“…The synaptic serine protease neurotrypsin is thought to be important for adaptive synaptic processes required for cognitive functions, because humans deficient…”
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Stimulation of angiogenesis through cathepsin B inactivation of the tissue inhibitors of matrix metalloproteinases by Kostoulas, Georgios, Lang, Angela, Nagase, Hideaki, Baici, Antonio

“…The tissue inhibitors of matrix metalloproteinases (MMPs), TIMP-1 and TIMP-2, are also angiogenesis inhibitors. Cathepsin B and MMPs are found at sites of…”
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Regulation of human cathepsin B by alternative mRNA splicing: homeostasis, fatal errors and cell death by Baici, Antonio, Müntener, Kathrin, Willimann, Anna, Zwicky, Roman

“…One of the control mechanisms of cathepsin B biosynthesis and trafficking operates through alternative splicing of pre-mRNA. An mRNA lacking exon 2 is more…”
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Kinetics of Molecular Chaperone Action by Schmid, Daniel, Baici, Antonio, Gehring, Heinz, Christen, Philipp

“…Molecular chaperones of the Hsp70 type transiently sequester unfolded segments of proteins and promote their correct folding. Target peptides were labeled with…”
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Purification and enzymological characterization of murine neurotrypsin by Reif, Raymond, Sales, Susanne, Dreier, Birgit, Lüscher, Daniel, Wölfel, Jens, Gisler, Claudio, Baici, Antonio, Kunz, Beat, Sonderegger, Peter

“…An increasing number of studies indicate that serine proteases play an important role in structural plasticity associated with learning and memory formation…”
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Dual concentration-dependent activity of thyroglobulin type-1 domain of testican: specific inhibitor and substrate of cathepsin L by Meh, Primoz, Pavsic, Miha, Turk, Vito, Baici, Antonio, Lenarcic, Brigita

“…The thyroglobulin type-1 (Tg-1) domain is a protein module that occurs in a variety of secreted and membrane proteins and is recognised as a potent inhibitor…”
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The Axonally Secreted Serine Proteinase Inhibitor, Neuroserpin, Inhibits Plasminogen Activators and Plasmin but Not Thrombin by Osterwalder, Thomas, Cinelli, Paolo, Baici, Antonio, Pennella, Amedea, Krueger, Stefan Robert, Schrimpf, Sabine Petra, Meins, Marita, Sonderegger, Peter

“…Neuroserpin is an axonally secreted serine proteinase inhibitor that is expressed in neurons during embryogenesis and in the adult nervous system. To identify…”
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Cytoskeletal architecture and cathepsin B trafficking in human articular chondrocytes by Zwicky, R, Baici, A

“…In the differentiated state, human articular chondrocytes exhibited modestly developed cytoskeletal components, while cells dedifferentiated by serial…”
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Folding Competence of N-terminally Truncated Forms of Human Procathepsin B by Müntener, Kathrin, Willimann, Anna, Zwicky, Roman, Svoboda, Barbara, Mach, Lukas, Baici, Antonio

“…Besides acting as an inhibitor, the propeptide of human cathepsin B exerts an important auxiliary function as a chaperone in promoting correct protein folding…”
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Interaction between Human Cathepsins K, L, and S and Elastins by Novinec, Marko, Grass, Robert N., Stark, Wendelin J., Turk, Vito, Baici, Antonio, Lenarčič, Brigita

“…Proteolytic degradation of elastic fibers is associated with a broad spectrum of pathological conditions such as atherosclerosis and pulmonary emphysema. We…”
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Exon Skipping of Cathepsin B by Müntener, Kathrin, Zwicky, Roman, Csucs, Gabor, Rohrer, Jack, Baici, Antonio

“…The alternatively spliced messenger RNA of the human cysteine peptidase cathepsin B missing exons 2 and 3 encodes a truncated form of the enzyme lacking the…”
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Very Rapid, Ionic Strength-Dependent Association and Folding of a Heterodimeric Leucine Zipper by Wendt, Hans, Leder, Lukas, Härmä, Harri, Jelesarov, Ilian, Baici, Antonio, Bosshard, Hans Rudolf

“…Leucine zippers (coiled coils) are dimerization motifs found in several DNA-binding transcription factors. A parallel leucine zipper composed of the acidic…”
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Paradoxical interactions between modifiers and elastase-2 by Schenker, Patricia, Baici, Antonio

“…The serine endopeptidase elastase-2 from human polymorphonuclear leukocytes is associated with physiological remodeling and pathological degradation of the…”
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interferENZY: A Web-Based Tool for Enzymatic Assay Validation and Standardized Kinetic Analysis by Pinto, Maria Filipa, Baici, Antonio, Pereira, Pedro José Barbosa, Macedo-Ribeiro, Sandra, Pastore, Annalisa, Rocha, Fernando, Martins, Pedro M.

“…Enzymatic assays are widely employed to characterize important allosteric and enzyme modulation effects. The high sensitivity of these assays can represent a…”
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Simultaneous interaction of enzymes with two modifiers: Reappraisal of kinetic models and new paradigms by Schenker, Patricia, Baici, Antonio

“…Enzyme activity can be modulated by the concurrent action of two modifiers, either activators or inhibitors. The kinetic mechanisms for the interaction of the…”
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Dendrochronological investigation of the bowed string instruments at the Theatre Museum Carlo Schmidl in Trieste, Italy by Bernabei, Mauro, Bontadi, Jarno, Čufar, Katarina, Baici, Antonio

“…The Civico Museo Teatrale Carlo Schmidl in Trieste, Italy, hosts a collection of bowed string instruments, the majority of which have been made by local violin…”
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