Search Results - "Bai, Ruisong"
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Nonlinear analysis of the locomotive traction system with rub-impact and nonlinear stiffness
Published in Advances in mechanical engineering (01-12-2018)“…Considering rub-impact forces, eccentricity of rotor, and nonlinear stiffness of armature shaft, a dynamic differential equation is built to investigate the…”
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The Hypoglycemic Effect of JinQi Jiangtang Tablets Is Partially Dependent on the Palmatine-Induced Activation of the Fibroblast Growth Factor Receptor 1 Signaling Pathway
Published in Frontiers in pharmacology (22-07-2022)“…JinQi Jiangtang tablet (JQJTT) is a Chinese patent medicine that has been shown to be beneficial for patients with diabetes both preclinically and clinically;…”
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Meeting organometallic chemistry with drug discovery: CH activation enabled discovery of a new ring system of 12H-Indazolo[2,1-a]cinnolin-12-ones with anti-proliferation activity
Published in Bioorganic & medicinal chemistry letters (15-02-2020)“…A diverse library of new ring system 12H-indazolo[2,1-a]cinnolin-12-ones have been synthesized efficiently via Ru (II) or Rh (III) C–H activation strategy,…”
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Synthesis of Indazolo[2,1-a]Cinnolines via Rhodium (III)-Catalyzed C–H activation/annulation under mild conditions
Published in Tetrahedron (26-07-2019)“…A simple, robust and efficient Rh(III)-catalyzed synthesis of novel 12H-indazolo[2,1-a]cinnolin-12-ones has been developed via tandem C–H activation/annulation…”
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The EZMTT cell proliferation assay provides precise measurement for drug combinations and better correlation between in vitro and in vivo efficacy
Published in Bioorganic & medicinal chemistry letters (01-06-2020)“…[Display omitted] The rate of drug-induced proliferation (DIP) has been proposed as an unbiased alternative drug effect metric. However, current assays are not…”
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Design and synthesis of novel tellurodibenzoic acid compounds as kidney-type glutaminase (KGA) inhibitors
Published in Bioorganic & medicinal chemistry letters (01-07-2019)“…[Display omitted] Organotellurium compounds have been reported as an immune-modulator sensitizing chemotherapeutics. Herein, we report the design and synthesis…”
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Synthesis of Novel Kidney-Type Glutaminase Allosteric Inhibitors Targeting the Critical Lys-320 Residue
Published in ACS medicinal chemistry letters (12-01-2023)“…Reversible allosteric inhibitors of kidney-type glutaminase (GLS1, KGA) showed incomplete inhibition of cancer cell proliferation and poor in vivo efficacy…”
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