Hepatitis Status, Child-Pugh Classification, and Serum AFP Levels Predict Survival in Patients Treated With Transarterial Embolization for Unresectable Hepatocellular Carcinoma

Hepatitis Status, Child-Pugh Classification, and Serum AFP Levels Predict Survival in Patients Treated With Transarterial Embolization for Unresectable Hepatocellular Carcinoma

Hepatocellular carcinoma (HCC) represents one of the most prevalent cancers worldwide. Most patients are not surgical candidates, and transarterial embolization (TAE) has been used to treat patients with unresectable HCC. The purpose of this study was to identify factors that predict survival in pat...

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Bibliographic Details
Published in:Journal of gastrointestinal surgery Vol. 9; no. 5; pp. 638 - 645
Main Authors: Reichman, Trevor W., Bahramipour, Phil, Barone, Alison, Koneru, Baburao, Fisher, Adrian, Contractor, Daniel, Wilson, Dorian, Dela Torre, Andrew, Cho, Kyunghee C., Samanta, Arun, Harrison, Lawrence E.
Format: Journal Article
Language:English
Published: United States Elsevier Inc 01-05-2005
Springer Nature B.V
Subjects:
Adult
Aged
Aged, 80 and over
alpha fetoprotein
alpha-Fetoproteins - analysis
Biomarkers, Tumor - analysis
Cancer
Carcinoma, Hepatocellular - blood
Carcinoma, Hepatocellular - mortality
Carcinoma, Hepatocellular - pathology
Carcinoma, Hepatocellular - therapy
Children & youth
Classification
embolization
Embolization, Therapeutic - methods
Female
Hepatitis
Hepatitis, Viral, Human - pathology
Hepatitis, Viral, Human - physiopathology
Hepatocellular carcinoma
Humans
Liver cancer
Liver Neoplasms - blood
Liver Neoplasms - mortality
Liver Neoplasms - pathology
Liver Neoplasms - therapy
Male
Middle Aged
Neoplasm Staging
Predictive Value of Tests
Probability
Prognosis
Proportional Hazards Models
Registries
Retrospective Studies
Risk Assessment
Survival Analysis
Treatment Outcome
embolization
alpha fetoprotein
Hepatocellular carcinoma
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Summary:Hepatocellular carcinoma (HCC) represents one of the most prevalent cancers worldwide. Most patients are not surgical candidates, and transarterial embolization (TAE) has been used to treat patients with unresectable HCC. The purpose of this study was to identify factors that predict survival in patients treated with TAE at a Western medical center. Review of a prospective database identified 345 patients treated for HCC at University Hospital (Newark, NJ) between July 1998 and July 2004. Of these patients, 109 patients underwent TAE. Eleven of these patients were subsequently treated surgically and excluded from this study. Of the remaining 98 patients, demographic data and laboratory values were analyzed to predict survival by univariate and multivariate analysis. Several factors, including hepatitis status, Child-Pugh classification, serum alpha fetoprotein levels <500 ng/ml, bilirubin <2.0 mg/dl, prothrombin time <16 seconds, platelet count <200 × 10 9/l, albumin >3.5 gm/dl, and multiple treatments, predicted survival by univariate analysis. Serum alpha fetoprotein levels, Child-Pugh classification, and hepatitis status were found by multivariate analysis to independently predict survival. These factors may help to select patients with unresectable HCC who might benefit from TAE.
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ISSN:1091-255X
1873-4626
DOI:10.1016/j.gassur.2004.11.002